1YTY


Conserved Protein Domain Family
LARP_3

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cd08028: LARP_3 
Click on image for an interactive view with Cn3D
La RNA-binding domain of La-related protein 3
This domain is found at the N-terminus of the La autoantigen and similar proteins, and co-occurs with an RNA-recognition motif (RRM). Together these domains function to bind primary transcripts of RNA polymerase III at their 3' terminus and protect them from exonucleolytic degradation. Binding is specific for the 3'-terminal UUU-OH motif. The La autoantigen is also called Lupus La protein, LARP3, or Sjoegren syndrome type B antigen (SS-B).
Statistics
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PSSM-Id: 153397
View PSSM: cd08028
Aligned: 14 rows
Threshold Bit Score: 120.097
Threshold Setting Gi: 225712916
Created: 16-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1YTY_A ; human La bound to UUUoh 3'-termini of nascent RNA Pol III transcripts; contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  #  ##    #  ## #                    ###                               
1YTY_A        10 XAALEAKICHQIEYYFGDFNLPRDKFLKEQIKld-eGWVPLEIXIKFNRLNRLTTDf-NVIVEALSKSkaelXEISEd-- 85  human
NP_955841      7 MSPLEKKVAEQIEYYFGDHNLPRDKFLKEQLQld-dGWVPLETMLKFNRLKSLTSEe-SVIVESLLKSktglLEISEd-- 82  zebrafish
XP_001637883  16 LSPLEQKIVKQIEFYFGDKNLPRDKFLRQKTEed-dGWVTFECLATFNRLKSMSDDv-NFLAKTMKKSssdlIEVSEd-- 91  starlet sea ane...
O01806         9 HDDADQKIIKQLEYYFGNINLPRDKFLQEKLKed-dGWVPITTMLNFNRLASISKDt-EKIANAVKNSgsgiISVSEd-- 84  Caenorhabditis ...
Q26457        40 VSKLEASTIRQLEYYFGDANLARDKFLQEQISkd-eGWVPVDVLLTFKRLKSLSEDk-KVIVDAIEKSdeglIEVSEd-- 115 Asian tiger mos...
P40796        47 FTKQERAIIRQVEYYFGDANLNRDKFLREQIGknedGWVPLSVLVTFKRLASLSTDl-SEIVAALNKSeeglVEISEd-- 123 fruit fly
ACO12304       4 MDKVKAKIVRQVDYYFGDFNLSRDKFLKEKIKecegGWIDMDIMLKFQRLSALASGdaALVLKALKEAggdlVEVDEe-- 81  salmon louse
XP_002119316  13 ADQLGKRLIRQIEFYFGDFNLHRDKFMQEEMKkn-dGWFTMDTMLKFKRLSSMCSEp-GTILAALKQSksglMEIDIe-- 88  Ciona intestinalis
EEB10872      30 PVDINEEILKQVEYYFGDNNLRKDKFMLNQIKmd-dGWIPMSVMLEFRRLAKLSSDp-KVIANALGKSk--lIEVDEsge 105 human body louse
CAZ35256      11 ITPLESKIIRQVEYYFGDVNLSRDKFMKEAVKen-dGWIPMETMIKFNRLKSLSEDa-EFIKKSVSKSqsglIEVGE--- 85  Schistosoma man...
Feature 1              
1YTY_A        86 kTKIRR 91  human
NP_955841     83 kTKIRR 88  zebrafish
XP_001637883  92 lTKVRR 97  starlet sea anemone
O01806        85 nQKIRR 90  Caenorhabditis elegans
Q26457       116 rEKLRR 121 Asian tiger mosquito
P40796       124 kLSLRR 129 fruit fly
ACO12304      82 kSRIRR 87  salmon louse
XP_002119316  89 nQSIRR 94  Ciona intestinalis
EEB10872     106 eIKIRR 111 human body louse
CAZ35256      86 -KGLRR 90  Schistosoma mansoni

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