2HA9


Conserved Protein Domain Family
RNR_PFL_like_DUF711

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cd08025: RNR_PFL_like_DUF711 
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Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase
This subfamily contains Streptococcus pneumoniae Sp0239 and similar uncharacterized proteins. Sp0239 is structurally similar to ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL), which are believed to have diverged from a common ancestor. RNR and PFL possess a ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. PFL is an essential enzyme in anaerobic bacteria that catalyzes the conversion of pyruvate and CoA to acteylCoA and formate.
Statistics
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PSSM-Id: 153090
View PSSM: cd08025
Aligned: 18 rows
Threshold Bit Score: 563.07
Threshold Setting Gi: 170290665
Created: 3-Nov-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2HA9_A         5 RQVTETIAXIEEQNFDIRTITXGISLLDcidpdinrAAEKIYQKITTKAANLVaVGDEIAAELGiPIVNKRVSVTPi-sL 83  Streptococcus p...
NP_562413      5 NEILETISMIKEQNLDVRTITLGLSLMDcacedvkvLSEKIYDKITKTAENLVkTGENIEKRFGiPIINKRISVTPi-sI 83  Clostridium per...
ZP_04858789    5 VEIQETNRMIAEANLDVRTITMGISLIDcadpdinkFNENIYKKITTYAKDLVkVGDEIAKQFGvPVVNKRISVTPi-aI 83  Fusobacterium v...
CBA03588       6 GEILETVKMVADQNFDVRTITIGIDLHDcissdinvLNQNIYNKITTVGKDLVaTAKYLSAKYGvPIVNQRISVTPi-aQ 84  Neisseria menin...
NP_614497      7 EEVIETIEMIRMRNLDVRAVTLGINLLDrahpdpeeLARDVREKIVEVAGDLVeVVEEVEDELGvPIVNKRIAVTPc-sI 85  Methanopyrus ka...
ZP_04563420    5 FEVAETNKMIEQENLDVRTITLGISLLDcmdhdidvLCENIYKKITTVAKNLVsTGKQIEMKYGiPIVNKRISVTPi-gF 83  Mollicutes bact...
NP_248675      5 EEIIETIKMIKMENLDLRTVTLGLSLRDcvskdldeLKENIYNKITSSAENLVeTAERISEKYGiPIVNKRIAVTPislV 84  Methanocaldococ...
YP_001737481   7 NEISEILEMLSFQNLDIRAVTLGVDILPslr--yddVKEGIISVIEEKASGFReAVDTVARRLGvKIVTKRLAVTPt-cY 83  Candidatus Kora...
NP_560838      6 KEIGEILEMLLFRELDIRAVTLSVNTLPairhrvsdTISALEELLEPYLKKLRpAVEKVASRLGvRIVTVRLAVSPvsiM 85  Pyrobaculum aer...
YP_001190444   6 EEIAEVINMLTHEDLDIRSVTLSVNTLFavsd-vpeRALEKLSSLRSAFSRFSeVVNSVQDKLGvKIVTKRVAVSPv-qY 83  Metallosphaera ...
2HA9_A        84 IGAAtda-------tdYVVLAKALDKAAKEigvDFIGGFSALVQKGyqkgdeILINSIPRALaetdKVCSSVNIGSTKSg 156 Streptococcus p...
NP_562413     84 VAAScnc-------nsYLSIAKAMDKAAKEvgvDFIGGFSALVHKGftesdlKLIKSLPESLantdIVCSSVNIGSTRYg 156 Clostridium per...
ZP_04858789   84 AAAGckt-------dsYVSIAKTLDKAAQEcgvNFIGGFSALVQKGctpsdrILIDSIPEALavteRVCSSVNIGTSRNg 156 Fusobacterium v...
CBA03588      85 IAAAtha-------dsYVSVAQTLDKAAKAigvSFIGGFSALVQKGmspsdeVLIRSIPEAMkttdIVCSSINVGSTRAg 157 Neisseria menin...
NP_614497     86 VAASavrke---greaVLTLAEALDEAAEEvgvDYLGGYTALVYDGfteadeAVLDTIPEAIegteRLCASVVVADERYg 162 Methanopyrus ka...
ZP_04563420   84 VGSNacks-----tadFVKIAKTLDKCAHEtgvNFIGGYTAIVSKGmtkaeeLLIRSIPEAMkvtsNVCSSVNVGSTKTg 158 Mollicutes bact...
NP_248675     85 IGGAikdldkeeqikaCVEVGEVLDKAAKKvrvDFLGGYSALVHKDatkedrALIDSIPFMMekteRVCSSVNVASTKTg 164 Methanocaldococ...
YP_001737481  84 LVDSlasdkd-earevAVEIGLSLEEASEElklDYVGGHAAFVDSGfsigdyGVIYSIPEVLssseRLSSLVNAASTAHg 162 Candidatus Kora...
NP_560838     86 LEPIgda-------ksTVELAYFLDDLAGKygvDMVGGFSAFEHAGvsrgdrALMEGLAEALngtsRLAGFLNVASTMTg 158 Pyrobaculum aer...
YP_001190444  84 FLEPypd------vkyAIKLGEFLDTLAREseiDYIGGFSAYADRGisrgahVMLQSLADTMnstsRLSSMLNAASTQEg 157 Metallosphaera ...
2HA9_A       157 inXTAVADXGRIIKETANlsd----xgvAKLVVFANAVEdnpfXAGAFHGVGEadvIINVGVSGPgvVKRALEKVRGqsf 232 Streptococcus p...
NP_562413    157 inMDAVKLMGETIKETSLitpd--gfgcAKLVVFCNAVEdnpfMAGAFHGVGEaekVINVGVSGPgvVKKALEEVRGksf 234 Clostridium per...
ZP_04858789  157 lnMNAVKKMGEIIVKTAEltkdrdsigcAKLVVFCNAVEdnpfMAGAFHGVGEadcVINVGVSGPgvVKRALMEVRDadf 236 Fusobacterium v...
CBA03588     158 inMDAVKLAGETIKRTAEitpe--gfgcAKIVVFCNAVEdnpfMAGAFHGSGEadaVINVGVSGPgvVKAALENSDAttl 235 Neisseria menin...
NP_614497    163 inMDAVYRTAEAVKETAErtdg---hgcARLVALTNAPEntpfMAGAFHGVGQpeaCVNVGISGPgvVRAVVEELKDvdf 239 Methanopyrus ka...
ZP_04563420  159 inMDAVKLMGEIIHETADltkendsigcAKLVVLCNAPDdnpfMAGAFHGVSEadaIINVGVSGPgvVKNAIANAKGkdf 238 Mollicutes bact...
NP_248675    165 inMDAVKRMGEIIKETAFrtek--aigcAKLVVFANAPEdnpfMAGAFHGVGEgdkVINVGVSGPgvVRAVIEKLPDadf 242 Methanocaldococ...
YP_001737481 163 inIEAVSIMGVIIKELAEldy----rgcTRLGVFANAIGgtpfIPGAYHDGREndpVINIAISGPgvVESVVKLLEGkdl 238 Candidatus Kora...
NP_560838    159 inLDAVRKSADIILSLKPha-------aARFAVTANLPEdvpfMPGAYHGLGLpdaVINIAVSGPgvVEAVVRNLPEada 231 Pyrobaculum aer...
YP_001190444 158 lnVDAVKLFTSQLLRMSSha-------sSRVAIMANSPQdspfVPSAHHGRGMpnsSINIAVSGPgvVAGAIRRAKPatf 230 Metallosphaera ...
2HA9_A       233 DVVAETVKKTAFKITRIGQLVGQXASErlgvEFGIVDLSLAPTPavgdSVARVLEEXGLETVgtHGTTAALALLNDQVKK 312 Streptococcus p...
NP_562413    235 EEVAETIKKTSFKVTRMGQLVAKEASKlmdiPFGIVDLSLAPTPavgdSVGRVLEEMGLSNCgtHGTTAALALLNDAVKK 314 Clostridium per...
ZP_04858789  237 ETLCEVVKKTAFKITRVGQIVAQEASRrlnvPFGIIDLSLAPTPaigdSIAEIFQEMGLEHAgaPGTTAALAILNDNVKK 316 Fusobacterium v...
CBA03588     236 TEVAEVVKKTAFKITRVGELIGREASKmlniPFGILDLSLAPTPavgdSVARILEEMGLSVCgtHGTTAALALLNDAVKK 315 Neisseria menin...
NP_614497    240 RTLHDEIKRTAFKITRVGELVGRRVAErlgvEFGAVDLSLAPTPeegdSVAEILEGIGLESCgcPGSTAALHLLMDAVKK 319 Methanopyrus ka...
ZP_04563420  239 GELCEIIKKTAFKITRVGQLVALEASEklgiPFGIIDLSLAPTPaigdSIADCLEGMGLDSVgaPGTTAALAILNDQVKK 318 Mollicutes bact...
NP_248675    243 GTLANEIKKVAFKITRVGELIGREVSKelgvKFGVVDLSLAPTPargdSIANILEAMGLEKCgtHGSTAALALLNDAVKK 322 Methanocaldococ...
YP_001737481 239 RTIHDAIKRVAFKITRLGELVGREVAEvmgaKFGSVDLSLAPTPaigdSVAGILRAMGVEEVgaPGSLLALAVLTDAVKK 318 Candidatus Kora...
NP_560838    232 RTLHDAIKRAAFKITRLGELVGREVSKelgvPFGAVDLSVAPSPkvgdSVAAILEAMGLPRVgsPGSVFALALFVDAVKK 311 Pyrobaculum aer...
YP_001190444 231 QELYEVIKKASFKVTRLGELVGRMVSEelgvAMGSVDLSLAPSPkvgdSVAEILEVMGISKVggHGSLTALAILMDAVKK 310 Metallosphaera ...
2HA9_A       313 GGVXACNQVGGLSGAFIPVSEDEGXIAAVQngSLNLEKLEAXTAICsVGLDXIAIPEdtpAETIAAXIADEAAIGvinXK 392 Streptococcus p...
NP_562413    315 GGLMASSYVGGLSGAFIPVSEDECMIEQSKngFLTIEKLEAMTCVCsVGLDMIAIPGktsASTISGIIADEAAIGminNK 394 Clostridium per...
ZP_04858789  317 GGVMASSYVGGLSGAFIPVSEDHAMIEAAKagALTLEKLEAMTCVCsVGLDMIAIPGsttAATISGIIADEAAIGminNK 396 Fusobacterium v...
CBA03588     316 GGMMASSAVGGLSGAFIPVSEDEGMIAAAEagVLTLDKLEAMTAVCsVGLDMIAVPGdtpAHTISGIIADEAAIGminSK 395 Neisseria menin...
NP_614497    320 GGAAATSRHGGYSEAFIPVSEDAGMARAAEe-ALTLEKLEAMTAVCsVGIDMVVVPGdtpVETIAGIIADEAAIGvvtGK 398 Methanopyrus ka...
ZP_04563420  319 GGVMASSYVGGLSGAFIPVSEDQGMIDAVNrgALTLEKLEAMTCVCsVGLDMIAIPGdtpVTTLSGIIADEMAIGminQK 398 Mollicutes bact...
NP_248675    323 GGAMATSYVGGLSGAFIPVSEDSGMVEAVEagALTLEKLEAMTCVCsVGIDMVAIPGdtpASTISAIIADEMAIGvinNK 402 Methanocaldococ...
YP_001737481 319 GGAMATSSVGGLSGAFIPVSEDSGMAEAIRrgALNLQALLSMTAVCsTGIDMVPIPGeveADKISAIIGDVMALAvtlDK 398 Candidatus Kora...
NP_560838    312 GGAMAVSNIGGLSGAFIPVSEDAVMAQAAAegAVTLDTLKAMAAVCnTGLDMIGIPGdasADVVAAIIADVMALAvylDK 391 Pyrobaculum aer...
YP_001190444 311 GGSMATNLVGGLSSAFIPVSEDSIMALRMRegYLELNDLLAMSAVCnSGIDMVGVPRdagQDKITALILDVLSLGlmlNK 390 Metallosphaera ...
2HA9_A       393 TTAVRIIPKG 402 Streptococcus pneumoniae
NP_562413    395 TTAVRIIPVP 404 Clostridium perfringens str. 13
ZP_04858789  397 TTAARLIPVI 406 Fusobacterium varium ATCC 27725
CBA03588     396 TTAVRIIPVT 405 Neisseria meningitidis alpha153
NP_614497    399 PTAVRIIPAP 408 Methanopyrus kandleri AV19
ZP_04563420  399 TTAVRIIPVI 408 Mollicutes bacterium D7
NP_248675    403 TTAVRIIPVP 412 Methanocaldococcus jannaschii DSM 2661
YP_001737481 399 VLGVRLIPVP 408 Candidatus Korarchaeum cryptofilum OPF8
NP_560838    392 PLGVRLVPVP 401 Pyrobaculum aerophilum str. IM2
YP_001190444 391 IVGVRVIPIE 400 Metallosphaera sedula DSM 5348
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