Conserved Protein Domain Family
GH16_CCF

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cd08024: GH16_CCF 
Coelomic cytolytic factor, member of glycosyl hydrolase family 16
Subgroup of glucanases of unknown function that are related to beta-GRP (beta-1,3-glucan recognition protein), but contain active site residues. Beta-GRPs are one group of pattern recognition receptors (PRRs), also referred to as biosensor proteins, that complexes with pathogen-associated beta-1,3-glucans and then transduces signals necessary for activation of an appropriate innate immune response. Beta-GRPs are present in insects and lack all catalytic residues. This subgroup contains related proteins that still contain the active site and are widely distributed in eukaryotes. Their structures adopt a jelly roll fold with a deep active site channel harboring the catalytic residues, like those of other glycosyl hydrolase family 16 members.
Statistics
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PSSM-Id: 185694
Aligned: 32 rows
Threshold Bit Score: 450.929
Created: 2-Nov-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:based on homology to other subfamilies

cd08024 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd08024 is a member of the superfamily cl22861
Sub-family Hierarchy
cd00413Glyco_hydrolase_16cd02175GH16_lichenasecd02176GH16_XETcd02177GH16_kappa_carrageenasecd02178GH16_beta_agarasecd02183GH16_fungal_CRH1_transglycosylasecd08023GH16_laminarinase_likecd02179GH16_beta_GRPcd02180GH16_fungal_KRE6_glucanasecd02181GH16_fungal_Lam16A_glucanasecd02182GH16_Strep_laminarinase_likecd08024GH16_CCF
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
XP_002211528 142 LIFEENWDk---lDFDRWQHELTMSGGGNWEFQMYVnnrsNSYVRDNTLFIKPTLTsdkygeaalsse--vvdmwgmspa 216 Florida lancelet
ABO40828     121 VFFRDDFNy---iDTNNWRYEVSAYGGLNREFQVYTndprNVFTRSGNLYLKPTIStddprfnentlr--wgvmdvartw 195 bloodfluke planorb
BAG82630     121 VVFRDDFNh---fNKGHFTTEVSAWGGGNGEFQVYTpetaNLYTANGYLYLKPTLTvdhhsfnegtly--ngnmdvrgiw 195 Pacific oyster
EAK84492      64 LILDDDFSng--fNKSTWSHEIQVGGYGTGSFDWTTdseaNTYVEDGKLYLVPTLTvenfwppyfnmd---glkidlaas 138 Ustilago maydis...
EAK83930      87 LVLEDHFDgp--lNTSLWVPEVSVGGNGNGEFQWTTdspkNAYTEDGMLYIVPTLTadaigeanvyd----gytvnltad 160 Ustilago maydis...
XP_759706    142 LAFQDDFTgrttlNTDNWEYEVKADGFGNKEFQMTTtqadNSFIEDGKLYLVPTLTsdevgeaait------gnytysln 215 Ustilago maydis...
ACM68926     117 VVFRDDFHs---fNKGSYKIECSAWGGGNHEFQVYVnepsNLYARGGHFYLKPTLTtddpryddnrlyhgqmkvtdfcgg 193 Perna viridis
BAH84971      40 TVFEDSFNsh-qlNPKHWHHEITCWGGGNGEFQMYTpeaaNTYIKNGVLYLKPTFTadkfgddffqh----gvldvkqqw 114 Haliotis discus...
AAW34372      16 AGFRDDFTt---wDPSDYQIEVSAWGGGNHEFQVFTpepsNLFVRNGNLYIKPTFTrdsahfndgsly--ygtmdvnslw 90  Yesso scallop
AAP74223     121 VVFRDDFNga--fDPAGWNYEVSMYGGYNWEVQAYVpdarNIFTRNGHLFIKPTLTtdhpnyndgnln--satmdltaly 196 surf-clam
Feature 1                                                                                        
XP_002211528 217 dqCTGnaf-------------------wgCQRtgtg--tnyINPARSARLRSvnSFAFKYGKIEVEAKLPTGDWLWPAIW 275 Florida lancelet
ABO40828     196 gvCTNsan-------------------wgCYRegk---ygiLPPVMSGKLMS--NPTLRYGVVEVRARISKGDWIWPAIW 251 bloodfluke planorb
BAG82630     196 htCTNgvn-------------------ngCRKsayg--qeiLPPIMSGKVTT--HAAITYGRVNVRARVPKGAFIWPAIW 252 Pacific oyster
EAK84492     139 gnCTGlte-------------------kdCTMgnnhnegrmLNPIQSTRITTkkSHAIRYGKVEVRARTPTGNWLWPAIW 199 Ustilago maydis...
EAK83930     161 gtCTTnevkwtkidkkvpmqvainsthtnCIArsnatlgtvIPPIQSARLTTkgTAAIRYGRVEVRARMPTGDWLWPAVW 240 Ustilago maydis...
XP_759706    216 stCTAfpqt-----------------sdaCESvsnstlgqvLLPVKSARIRT--KASINRGRIEVRARLPAGDWIWPAIW 276 Ustilago maydis...
ACM68926     194 gpCTQsan-------------------wgCDRtavn--gnvLNPIKSGKVTT--NAAIRYGTVTVRARIPEGDWLWPAIW 250 Perna viridis
BAH84971     115 gsCTAaqd-------------------ngCRRqg-----aqIPPIMSSKVFS--VASITHGRVEVVAKIPKGDWIWPAIW 168 Haliotis discus...
AAW34372      91 hrCTQhdn-------------------ngCHKqsyggdseiLPPVMSGKITT--NFAMTYGRVNVRAKIPKGDWLWPAIW 149 Yesso scallop
AAP74223     197 gyCTNadr-------------------ygCIRegr---ngiLPPVMSGKIKS--KKTIRFGKVEARCRIPRGDWIWPAIW 252 surf-clam
Feature 1                         # #  #                                                         
XP_002211528 276 MLPKHNSY--GQWPASGEIDLMESRGNkngrtaqgesigvdSMGTTMHWGPywpvng-yakthVTRTLSGETFGDrFHKW 352 Florida lancelet
ABO40828     252 MLPRDNVY--GGWPRSGEIDIMESRGNevgi-------gisQVSSTLHWGPspnen---rwsrTNGERRTGSWYDsFHTW 319 bloodfluke planorb
BAG82630     253 LLPRDNHY--GNWPRSGEIDLMETKGNawtseyg-gdhgirSIGSTLHWGPdaghncfqkthgEKYLNQPDGWHG-WHTY 328 Pacific oyster
EAK84492     200 MMPRDSVY--GIWPASGEIDLMESSGNmprhrm--deravgAVQSSYHFGPdwrtna-gghhtGYQFRWRDYFNQgFHNY 274 Ustilago maydis...
EAK83930     241 MMPRDSVY--GEWPRSGEIDIFENDGNqpksry---dvhsnAMRSTLHFGIdaahnl-qshwrGIRLLWRKYFNEeFHTF 314 Ustilago maydis...
XP_759706    277 MMPEDSVY--GEWPRSGEIDIMESKGNvvesrk---drfrnSVTSTLHWGPsaatdr-wgltsSNFSVPRDYFSEdFHTF 350 Ustilago maydis...
ACM68926     251 MLPRDWKY--GGWPRSGEIDLMEARCNsymkcgs-nlegvqEVASTLHWGPdagqnr-fykthGELDKGSGDWADgFHTY 326 Perna viridis
BAH84971     169 LLPPGWPWkyGAWPASGEIDIMESRGNvhlseangatqgvdRVLSTIHYGAspsqh--rqqgdSKTSKTGTTWADsFHTY 246 Haliotis discus...
AAW34372     150 MLPRDWSY--GGWPRSGEIDIMESRGNtkailgg-qnsgvnYVASTLHWGPaynhnafakthaSKRKYGGDDWHG-WHTY 225 Yesso scallop
AAP74223     253 MLPRDSVY--GGWPRSGEIDMMESRGNtvardgs-ghnhgvNEVGHLHWDQmpvi----idsvRRTGDLDGDWSHaMHTY 325 surf-clam
Feature 1                                                                                        
XP_002211528 353 GLEWTENDMTFFLD-DQEIMKADpg-pGGFWEYGEFsqqlg----pnaqNPWQYsns-klAPFDHEFYIILNLAVGGTNG 425 Florida lancelet
ABO40828     320 RLEWRPDSLITFVD-DQIVLSVT----PDFWQKGGFgg----------qNIWAGge--rmAPFDKEFYLILNVAVGGTNG 382 bloodfluke planorb
BAG82630     329 SLDWTRDHLSILVD-NQEIYRLTtp-gNGMYNYCPYhn---------ieDPWRNgp--hnAPFDQPFHLLLNVAVGGTSG 395 Pacific oyster
EAK84492     275 VLEWNEKRMRVYVDdPRYTLSYFefpkEPMWDAGKFadiqi---eppihNPWIRsdtpnvAPFDQHFYLILNVAVGGKYF 351 Ustilago maydis...
EAK83930     315 GLEWDEHGIWTWENtRNYRVLNKk--fHNFAIDRQPiqrddkgaiipppNPWLTann-kaAPFDQYFYLIMNVAVGGTGG 391 Ustilago maydis...
XP_759706    351 GMDWTPTTLTTWVD-KPTRQIMRldmnRDFFAFSKLshllwn--gtaiqDPWNGkk---sAPFDQNFYLILNVAVGGTNG 424 Ustilago maydis...
ACM68926     327 KLEWDANHIRVTVD-GRQILYVStp-gNSYWGWGGFgg----------sNPWAGgg--rdAPFDQYFQLILNVAVGGQYF 392 Perna viridis
BAH84971     247 SVDWTAGHIRMDID-NQPVMAWTtp-sQGYWSYSHQsg----------tNVWSQgg--ndAPFDGKMSLILNVAVGATNG 312 Haliotis discus...
AAW34372     226 SLDWTADHIITYVD-NVEMMRINtp-sQSFWGWGGFdg----------nNIWASgg--knAPFDKPFHLILNVAVGGDYF 291 Yesso scallop
AAP74223     326 RLDWTIDHIQVFVD-NRHIMNIP----QSRKVFGSLed---------lvDPIFGavepkaAPFDKQFYLILNVAIAGTNG 391 surf-clam
Feature 1                                                                   
XP_002211528 426 FFsdqdt-fspgKPWNNespTAFKDFWMAKNQ-WYPTWnadvnngeDAALQVKTIRVWK 482 Florida lancelet
ABO40828     383 FFpdnyn-wgkrKPWANnapAPDVDFFNARNE-WLPTWrg-----dETAMIVDYVEFRT 434 bloodfluke planorb
BAG82630     396 FFaegq--ydvpKSWRNdspHPMRDFWEHRGE-WLKTWhg-----dDVAMLIDYVEMIQ 446 Pacific oyster
EAK84492     352 QGag-------dIVWNTesaYPATTFWSNIKK-WYPSWptd---prERGMAIDRVRMWQ 399 Ustilago maydis 521
EAK83930     392 YFt--------nGPWSNsdpNAQRAFIEAKDKtWGPTWpnd---pkRRGMAVDYVKMWQ 439 Ustilago maydis 521
XP_759706    425 YFsdi----drnKPWQNggsNPVADFWAARSR-WLPTWptd---pkRRGMAIDSVKMWQ 475 Ustilago maydis 521
ACM68926     393 PQgcay---nhpRPWHDgspRQEAEFYEKKSE-WLSTWhg-----eRAAMVIDYVEMVQ 442 Perna viridis
BAH84971     313 YFqdswhntphaKPWKNnspTAMMDFWKSKQQ-WQSTWhg-----eDVAMKVKSVKMIQ 365 Haliotis discus hannai
AAW34372     292 GNgey----dvpKPWGNh--NPMRSFWEARHS-WEHTWqg-----dEVALVIDYIEMIP 338 Yesso scallop
AAP74223     392 FFpdnwt-ydqqKPWFSnspTELQDFWNARFQ-WLQTWhg-----dDVAMECDYVEMTQ 443 surf-clam

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