Conserved Protein Domain Family
WGR_PARP2_like

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cd08003: WGR_PARP2_like 
WGR domain of poly(ADP-ribose) polymerases
The WGR domain is found in a variety of eukaryotic poly(ADP-ribose) polymerases (PARPs). It has been called WGR after the most conserved central motif of the domain. The domain typically occurs together with a catalytic PARP domain, and is between 70 and 80 residues in length. It has been proposed to function as a nucleic acid binding domain. PARPs catalyze the NAD(+)-dependent synthesis of ADP-ribose polymers and their addition to various nuclear proteins. Higher eukaryotes contain several PARPs and and there may be up to 17 human PARP-like proteins, with three of them (PARP-1, PARP-2, and PARP-3) containing a WGR domain. The synthesis of poly-ADP-ribose requires multiple enzymatic activities for initiation, trans-ADP-ribosylation, elongation, branching, and release of the polymer from the enzyme. This subfamily is composed of human PARP-2 and similar proteins. Similar to PARP-1, PARP-2 is ubiquitously expressed and its activity is induced by DNA strand breaks. It also plays a role in cell differentiation, cell death, and maintaining genomic stability. Studies on mice deficient with PARP-2 shows that it is important in fat storage, T cell maturation, and spermatogenesis.
Statistics
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PSSM-Id: 153430
View PSSM: cd08003
Aligned: 16 rows
Threshold Bit Score: 157.489
Threshold Setting Gi: 115757018
Created: 23-Oct-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9UGN5       106 HVYCEGNdvYDVMLNQTNlqfNNNKYYLIQLLEDda-qrNFSVWMRWGRVGk-mGQHSLVACSgn-lNKAKEIFQKKFLD 182 human
XP_002128307  93 HVFVCGDtvYNAMLNQTNigqNNNKYYLLQVLKSni-gaEFCVWFRWGRVGkvaGTNLQKVTC----EKAVQLFEKKFKD 167 Ciona intestinalis
Q9TX06       140 HVYENGKdvYDATLNQTEisqNNNKXYIIQLLEAdd-gsSYSVWNRWGREGl-kGQSSRKDFGkgglNQAISLFCSKFYE 217 Dictyostelium d...
XP_002112044  23 HVYVEDDdiYNVMLNQTNiefNNNKYYAIQLLEDdn-akHFHVWTRWGRVGk-kGHSSTFACGsd-lDKAKSIFEQKFSD 99  Trichoplax adha...
XP_001893054 289 HVYTEFNnvYDALLNQTSaqcNKNKFFIIQLLESdi-ekRYWVWFRWGRVGy-kGQTSLNPCGtn-lTLAKKLFCDKFKN 365 agent of lympha...
AAY63869     123 HVYEKGSdvYQCTLNQTRvaaNNNKYFIMQLLEDda-esIYHVFTRWGRVGy-gGQNKTVTFSs--lGQALYLFEKTFRQ 198 Trypanosoma cruzi
ABG73230     103 HVYERDGtvFQFTLNQTNissNNNKFYITQLLEDda-rkNYFIFARWGRVGa-vGQYMLDPYLd--aRSAEQDFCSKFRE 178 Trypanosoma bru...
EER13749     397 YVDSEGVv-WHALLNQTNlrqNNNKYFKLQLLEDvktpgHYIAWFRWGRVGy-tGQMTSKGDDl---STAKHAFEQKFSD 471 Perkinsus marin...
XP_001638543  23 HVFCEGStiWDAMLNQTNvmnNNNKYYLIQLLEDnt-akKYYTWMRWGRVGf-dGQKNLQAFGan-lDAAKRTFEKKFSD 99  starlet sea ane...
XP_002121880  67 HVYTEQDlvFNAMLNQTNigsNNNKYYVIQLLKNnk-tsDFFIWLRWGRVGk-vAGKTLEAVGl---EQGKATFQKKFRE 141 Ciona intestinalis
Q9UGN5       183 KTKNNWEd----rEKFEKVPGKYDMLQMDY 208 human
XP_002128307 168 KTSNFWEn----rGHFEKVHGKYDLLEMDF 193 Ciona intestinalis
Q9TX06       218 KTKNTFTd----rANFKKVAGKYDMIELDY 243 Dictyostelium discoideum
XP_002112044 100 KTRNNWSd----rENFEKVRGKYDLVAIDY 125 Trichoplax adhaerens
XP_001893054 366 KTTNEWAe----rANFDKISGKYDYLPSDY 391 agent of lymphatic filariasis
AAY63869     199 KTANHWGs----rARFNAVKGRYELMDIDY 224 Trypanosoma cruzi
ABG73230     179 KTRNDWVd----rGRFKKVPGKYEYMEVDY 204 Trypanosoma brucei brucei
EER13749     472 KTVNDWHavatgeVPFSPRHNKYTYVKQDF 501 Perkinsus marinus ATCC 50983
XP_001638543 100 KTKNDWEd----rASFTKVQGKYDLLIMDY 125 starlet sea anemone
XP_002121880 142 KTGNYFHvf---nLPFVKKKGKYDLLEMDY 168 Ciona intestinalis
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