2EOC


Conserved Protein Domain Family
WGR_PARP3_like

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cd08002: WGR_PARP3_like 
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WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
The WGR domain is found in a variety of eukaryotic poly(ADP-ribose) polymerases (PARPs). It has been called WGR after the most conserved central motif of the domain. The domain typically occurs together with a catalytic PARP domain, and is between 70 and 80 residues in length. It has been proposed to function as a nucleic acid binding domain. PARPs catalyze the NAD(+)-dependent synthesis of ADP-ribose polymers and their addition to various nuclear proteins. Higher eukaryotes contain several PARPs and and there may be up to 17 human PARP-like proteins, with three of them (PARP-1, PARP-2, and PARP-3) containing a WGR domain. The synthesis of poly-ADP-ribose requires multiple enzymatic activities for initiation, trans-ADP-ribosylation, elongation, branching, and release of the polymer from the enzyme. This subfamily is composed of human PARP-3 and similar proteins, including Arabidopsis thaliana PARP-2. PARP-3 displays a tissue-specific expression, with highest amounts found in the nuclei of epithelial cells of prostate ducts, salivary glands, liver, pancreas, and in the neurons of terminal ganglia. Unlike PARP-1 and PARP-2, PARP-3 activity is not induced by DNA strand breaks. However, it co-localizes with Polycomb group bodies and is part of complexes making up DNA-PKcs, DNA ligases III and IV, Ku70, and Ku80. PARP-3 is a nuclear protein that may be involved in transcriptional control and responses to DNA damage.
Statistics
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PSSM-Id: 153429
View PSSM: cd08002
Aligned: 10 rows
Threshold Bit Score: 135.61
Threshold Setting Gi: 41055510
Created: 20-Oct-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2EOC_A         25 PGTQVYEdYNCTLNQTNIenNNNKFYIIQLLQDsn-rFFTCWNRWGRVGevGQSKINHFTr--lEDAKKDFEKKFREKTK 101  human
XP_001782209  182 MNGKMEV-FDAMLNQTNLgdNNNKFYVLQLLEAdsgkNYYVFNRWGRVGvkGQQKLFGPWpd-aLPAIGEFKLKFYDKTR 259  Physcomitrell...
XP_002597282   43 NCAEVQDdYDCMLNQTNIghNNNKYYVIQLLRTigisRYFVWNRWGRVGepGQNAMKGPWd--lETAKKDFEKKFKDKTK 120  Florida lancelet
XP_002165279  112 NASVVDD-YDCMLNQTNVghNNNKFYVIQLICSg--aGYYVWNRWGRVGeaGANAIKGPFnd-qQYAIKEFTKKFKEKTK 187  green hydra
XP_785135      56 PGTVVDD-YDCMLNQTNIghNNNKFYLIQLLESy--sEYAVFTRWGRVGetGMNATQEFTkadeESAIKYFCKKFNDKTK 132  purple urchin
XP_002192099   58 LGARVYEdYDCTLNQTNIkaNNNKFYIIQLLEHn--gAYSVWSHWGRVGevGQSKLMPCAs--lEAAKKDFEKKFREKTK 133  zebra finch
Q11207        161 VLQRGDDvYDAILNQTNVrdNNNKFFVLQVLESdskkTYMVYTRWGRVGvkGQSKLDGPYds-wDRAIEIFTNKFNDKTK 239  thale cress
NP_001088845   70 GDYEVYEdYDCMLNQTNIgsNNNKFYVIQLITSk--kESYCWNRWGRVGelGQSKLSPFPn--lAGAQKDFEKKFKDKTK 145  African clawe...
XP_001745060   95 VYSDATEtFDCMLNQTNVghNNNKFYIIQVVQSg--gKYYCWTHWGRVGenGQNAALGPFas-pDGAISEFKKKFKAKAA 171  Monosiga brev...
NP_956795      59 SNAEVHEdYDCMLNQTNIgnNNNKFYVIQVLVSg--gKYYCWTRWGRVGesGQNALAGPSa--aDAAIKSFEKKFKEKTK 134  zebrafish
2EOC_A        102 NNWAerDHFVSHPgKYTLIEVQA 124  human
XP_001782209  260 NHWEerHNFQTHAnKYTWIEMDY 282  Physcomitrella patens subsp. patens
XP_002597282  121 NDWSkrGSFVPVPgKYTLLEMDT 143  Florida lancelet
XP_002165279  188 NNWEdkDNFQPVAgKYTLLEMDG 210  green hydra
XP_785135     133 NKWEnrANFEPKAgKYTLIEVED 155  purple urchin
XP_002192099  134 NSWAtrENFIAQPgKYTLIEVQP 156  zebra finch
Q11207        240 NYWSdrKEFIPHPkSYTWLEMDY 262  thale cress
NP_001088845  146 NSWSerENFTAHPgKYTMIEVQH 168  African clawed frog
XP_001745060  172 NNWEdrQNFKPKAgKYTLIDMAE 194  Monosiga brevicollis MX1
NP_956795     135 NNWSdrENFVSHSgKYTLIEVDG 157  zebrafish
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