1K30,1IUQ


Conserved Protein Domain Family
LPLAT_GPAT

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cd07985: LPLAT_GPAT 
Click on image for an interactive view with Cn3D
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT
Lysophospholipid acyltransferase (LPLAT) superfamily member: glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB). LPLATs are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. This subgroup includes glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB).
Statistics
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PSSM-Id: 153247
View PSSM: cd07985
Aligned: 8 rows
Threshold Bit Score: 354.822
Threshold Setting Gi: 221488215
Created: 7-Oct-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:putative G3P-binding pocket
Evidence:
  • Structure:1IUQ_A; Cucurbita moschata glycerol-3-phosphate acyltransferase binds glycerol and a sulfate ion in the putative glycerol-3-phosphate binding site, contacts at 5A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #  # #                          ####    
1K30_A       110 GNSFVGNls-----------lFKDIEEKLQQGHNVVLISNHQTEADPAIISLLLEKTn---PYIAENTIFVAGDRVLADP 175 crookneck pumpkin
1IUQ_A       109 GNSFVGNls-----------lFKDIEEKLQQGHNVVLISNHQTEADPAIISLLLEKTn---PYIAENTIFVAGDRVLADP 174 crookneck pumpkin
EEE26429     410 VPSPSASpaf--------aspLGRINERLAAGENVVFLSNHQTEPDPQVIKLVLDHLg--eTALANKMVFVAGHKVREDR 479 Toxoplasma gond...
XP_001771299 228 RNSYLGNlk-----------iFDQIEKNLKEGHNVIFLSNHQTEADPAVMALLLEHSh---PYLAENLTYVAGDRVVLDP 293 Physcomitrella ...
XP_002292905 198 ERSIIAGrd-----------nLDKAMEQIKNGENVVFLANHQSEADPQVVSCLFEKAgeeyGQLAADITYVAGHKVTTDP 266 Thalassiosira p...
XP_001694977 152 QNSVLGFre-----------rFDRVQELLDQKHNVVILANHQTEADPGVFAHMLAKTh---PKLATDVIYVAGDRVVTDP 217 Chlamydomonas r...
CAL52024     140 ANMYIGSlidydrsvmrqperWTTIQSQIDSGENVILFANHQSEGDAAFIPLFTEVTh---PGLGQRVTYVAGDRVVSDL 216 Ostreococcus tauri
Q9Z6V0        93 KNSRILNlh-----------rLKEIEEYIARGDNVVLLANHQTECDPQLMYYALGKTh---PELMENMIFVAGDRVTSDP 158 Chlamydophila p...
Feature 1                         ##                                         ### #               
1K30_A       176 LCKPFSIGRNLICVYSKKHMfdipe---ltetKRKANTRSLKEMALLLRGGSQLIWIAPSGGRDRPDPStGEWYPA-PFD 251 crookneck pumpkin
1IUQ_A       175 LCKPFSIGRNLICVYSKKHXfdipe---ltetKRKANTRSLKEXALLLRGGSQLIWIAPSGGRDRPDPStGEWYPA-PFD 250 crookneck pumpkin
EEE26429     480 LSTPFSLACNLLCVHSKKHLthpelsaeekheKQRENLAAMAALQQLLEEGGSVIWVAPSGGRDRQDDNgVFSQPD-PFD 558 Toxoplasma gond...
XP_001771299 294 FCKPFSMGRNLLCVYSKKHIhdvpd---laemKIKANAKTLRQMTILLRQGGQLLWVAPSGGRDRPDPEtNEWVPA-HFD 369 Physcomitrella ...
XP_002292905 267 LAVPFSMGRNLLCIHSKKHIdadpe---tkpaKSKQNMAAMNEMLQGLKEGGMAIWVAPSGGRDRRDIK-SSKIPIaSFD 342 Thalassiosira p...
XP_001694977 218 MCKPFSMGRNLFCVHSKKHMddape---lkaaKMETNRKTLVAMQRKLNEGGTLMWIAPSGGRDRPNAN-DEWVPD-NFD 292 Chlamydomonas r...
CAL52024     217 LAKPFSMGKDLLCVHSKKHMndnpk---ekskKMKQNLATVKEMQRLLNKGGMLIWIAPAGGRDRRQAD-GTLRPD-KFD 291 Ostreococcus tauri
Q9Z6V0       159 LARPFSMGCDLLCIYSKRHIatppe---lreeKLLHNQKSMQILKTLLNEGGKFIYVAPAGGRDRKNAE-GRLYPS-EFS 233 Chlamydophila p...
Feature 1                                                                                        
1K30_A       252 ASSVDNMRRLIQHSDv-----PGHLFPLALLCHDIMPPPsqvEIEIGEKRVIAFNGAGLSVAPEIsfeeiaath----kn 322 crookneck pumpkin
1IUQ_A       251 ASSVDNXRRLIQHSDv-----PGHLFPLALLCHDIXPPPsqvEIEIGEKRVIAFNGAGLSVAPEIsfeeiaath----kn 321 crookneck pumpkin
EEE26429     559 VKTVQMFRLLAKKIRhgsrgtLTHFYPMALFTALICPPPkqvEASLGEARSCAFSPVGVAVGESIadsdd---------- 628 Toxoplasma gond...
XP_001771299 370 SSAVENMKRLSDIVRv-----PAHLHALSLLCFEIMPPPvqvQKELGERRAVGFSGVGLAVSEQLdydsiaklv----dd 440 Physcomitrella ...
XP_002292905 343 QKTVDMFRLMGNKSKk-----PTHFYPMAMVSYDLCPPPdfvDPGVGEQRNVRFTPVGIAVMDEVpnvgga--------- 408 Thalassiosira p...
XP_001694977 293 PAAVELMRNLVQRAKq-----PGHLMPMSMFSYPMMPPPktvDKSIGERRLTAFTGVGISLCEELdvaaiiaas----gs 363 Chlamydomonas r...
CAL52024     292 PQAIEMMRKLGTKSSa----aKTHYYPFAMATYDIMPPPassEKQIGEKRIVNYTGVGLALGEEIdvssf---------- 357 Ostreococcus tauri
Q9Z6V0       234 PESIEVFRLLAKASNq-----TTHFYPFALKTYDILPPPpkiENAIGEQRAIFFAPVFFNFGAELffdalcskeelihcd 308 Chlamydophila p...
Feature 1                               
1K30_A       323 peevreaYSKALFDSVAMQYNVL 345 crookneck pumpkin
1IUQ_A       322 peevreaYSKALFDSVAXQYNVL 344 crookneck pumpkin
EEE26429     629 --qsheeFARKAEAETKRLYKLI 649 Toxoplasma gondii GT1
XP_001771299 441 sknakdaFSDAAWSEVNDMYNVL 463 Physcomitrella patens subsp. patens
XP_002292905 409 --ekrhlFTHHAEFSCIRGYEDL 429 Thalassiosira pseudonana CCMP1335
XP_001694977 364 eekeqkaLAKAAHDAVKESYAVL 386 Chlamydomonas reinhardtii
CAL52024     358 --sdsdeLSEHVWQKVAAEYDLI 378 Ostreococcus tauri
Q9Z6V0       309 khaqrtlRAEKVFSIVKNLYEEL 331 Chlamydophila pneumoniae

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