Conserved Protein Domain Family
TAF13

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cd07978: TAF13 
The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming the Transcription Factor IID (TFIID) complex. TFIID is one of seven General Transcription Factors (GTF) (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and assembly of the pre-initiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. TAFs from various species were originally named by their predicted molecular weight or their electrophoretic mobility in polyacrylamide gels. A new, unified nomenclature for the pol II TAFs has been suggested to show the relationship between TAFs orthologs and paralogs. Several hypotheses are proposed for TAFs functions such as serving as activator-binding sites, core-promoter recognition or a role in essential catalytic activity. Each TAF, with the help of a specific activator, is required only for expression of subset of genes and is not universally involved for transcription as are GTFs. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID. Several TAFs interact via histone-fold (HFD) motifs; the HFD is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamers. The minimal HFD contains three alpha-helices linked by two loops and are found in core histones, TAFs and many other transcription factors. TFIID has a histone octamer-like substructure. TAF13 interacts with TAF11 and makes a histone-like heterodimer similar to H3/H4-like proteins. The dimer may be structurally and functionally similar to the spt3 protein within the SAGA histone acetyltransferase complex.
Statistics
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PSSM-Id: 173962
View PSSM: cd07978
Aligned: 52 rows
Threshold Bit Score: 86.0451
Threshold Setting Gi: 162606102
Created: 1-Oct-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q15543        29 KRLFSKELRCMMYGFGDDQnPYTESVDILEDLVIEFITEMTHKAMSIG---RQGRV-QVEDIVFLIRKDPRKFARVKDLL 104 human
NP_001026273  24 STSFTPELQSMMFSLGDARrPLHESAILVEDIVHTQLINLLQQAAEVSq-lRGARViSAEDLLFLMRKDKKKLRRLLKYM 102 chicken
NP_001087409   1 MTSFVPELQSMMFSLGDARrPLHETAVLVEDIVHTQLINMLQQAAEVSq-mRGARViSAEDLLFLMRRDKKKLRRLLKYM 79  African clawed ...
XP_001652628  58 VPVFFDEISQIMRGYGDCEkPLRESVILVEKIVLHQLRGIMQEAIDHAmsrQNSPVlSRRDFEYIMRKNPVRVARLQKYF 137 yellow fever mo...
O75486       105 SISFATELQSMMYSLGDARrPLHETAVLVEDVVHTQLINLLQQAAEVSq-lRGARViTPEDLLFLMRKDKKKLRRLLKYM 183 human
XP_001607219  22 TLNYTAEVRQMMHGFGDHSePLIETAKIIEEVVLNQMRAIIRKACEVAd-mRESQVvSAEDFLFLLRKDKIKLQRLVNYL 100 jewel wasp
NP_001002625  21 ATSFIPELQSMMFALGDSRrPLHETAALVEDIVHTQLINLLHQAAEVAl-lRGARViSPEEIIFLMRKDKKKIRRLFKYM 99  zebrafish
EEY19368       5 SPQFKQEIQQMMYIAGETQdTSDETTTLIESIIHGQVVHMLTTANDLAl-rRGARLfTVADLIFQFRHNTPRVDRLRTFL 83  Verticillium al...
XP_002431675  12 GISYVKEIQLMMHGFGDVSePLVSSAQLIESILVQQMTCLWRNVLNVAqmqESNKP-TLEHFLFLLRKKPIKLKRFVKYL 90  human body louse
XP_001224510 337 GPKYRDEILKMMFVAGETRqPDVETTTMVENIVRDQTIHMLTVAGDLAahrGQTKF-TLDDIIFQVRNDAECLARLRNHM 415 Chaetomium glob...
Q15543       105 tmNEELKRARKAFD 118 human
NP_001026273 103 ffRDYKSKIVKGIE 116 chicken
NP_001087409  80 vfRDYKSKILKGIE 93  African clawed frog
XP_001652628 138 rdMAFVKKKMKDLY 151 yellow fever mosquito
O75486       184 fiRDYKSKIVKGID 197 human
XP_001607219 101 klKDFKTSMYKSLE 114 jewel wasp
NP_001002625 100 qfRDYKSKVLKTID 113 zebrafish
EEY19368      84 twKAIRKTVKDADD 97  Verticillium albo-atrum VaMs.102
XP_002431675  91 q-KKKMGMTFKMGC 103 human body louse
XP_001224510 416 qwKQIRKRAKVKDD 429 Chaetomium globosum CBS 148.51
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