1U0B,1LI7


Conserved Protein Domain Family
Anticodon_Ia_Cys
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cd07963: Anticodon_Ia_Cys 
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Anticodon-binding domain of cysteinyl tRNA synthetases
This domain is found in cysteinyl tRNA synthetases (CysRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. CysRS catalyzes the transfer of cysteine to the 3'-end of its tRNA.
Links
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Statistics
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PSSM-Id: 153417
Aligned: 50 rows
Threshold Bit Score: 145.783
Threshold Setting Gi: 33596886
Created: 28-Sep-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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anticodontRNA binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Structure:1U0B: Escherichia coli cysteinyl tRNA-synthethase binds the GCA anticodon of its cognate tRNA(Cys), contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1U0B_B       306 EENLKQARAALERLYTALRGTdkt--------vaPAGGEAFEARFIEAMDDDFNTPEAYSVLFDMAREVNRLKaed-maa 376 Escherichia coli
ZP_01166548  306 EDSLKEARVMLERFYQALRGVda---------veGPLENDFEERFIAAMNDDFNTPKAVSVMFELVNELNKATreg-ase 375 Neptuniibacter ...
YP_001340967 306 DQSLLEAKVALERLYTALRQQqv---------aeSFEPTVFTERFEEAMKDDFNTAVAVSVLFELVRELNKAKted-ank 375 Marinomonas sp....
ZP_03856430  306 FEALESAKRGVLRLYQAVGEDag---------paGSEFKDFRQRFESAMDDDFNTPQAIAVLFELARDVNALRseg--kd 374 Thermobaculum t...
ZP_01306025  307 EDGLKDAEAKLDRLYNAIHGCdlsav----ideqDAVVQDTRERFEAAMDDDFNTPKAIAVLFDLVNEINKKEga----e 378 Oceanobacter sp...
YP_433409    306 DVALEEARSGLERLYNSIRELygelg---avsmdEPLVGEYRERFHQAMDDDFNTSSAVAVLFDMAKAVNVAKked-rtr 381 Hahella chejuen...
ZP_01894474  282 EDNLAEAGRTLTRLYHALRGLvp---------akNVAETEHDQRFAEAMDDDFNTAGATAVLHAVANEINLHRregrdek 352 Marinobacter al...
YP_001209134 308 DAALEEAKRGLQRLYTALETApt---------tgGAILLPYQERFVAAMDDDFNTPQAIAVLFELAKMLNKAAaa----e 374 Dichelobacter n...
NP_840144    306 DAHLNDARSALERLYTVLKNHapsqdsevataviDWENNVYARRFMSAMNDDFNTPEAVAVLFDLASEANRTG------- 378 Nitrosomonas eu...
YP_544611    306 SHHLDDAKQALTRLYNTLRGRelp-------qldIDWRQPEAERFKQALDDDFNTPEAFAVLFELASEANRTG------- 371 Methylobacillus...

Feature 1                                                          #   #    #   #  #         ### 
1U0B_B       377 ANAMASHLRKLSAVLGLLe--qEPEAFLQsgaqa--ddsevAEIEALIQQRLDARKAkdWAAADAARDRLNEmGIVLEDG 452 Escherichia coli
ZP_01166548  376 APALAAQLRKLGGMLGLLq--qNADEFLQgesee--gglsnEEIEQLIVDRAEAKKAknFAEADKIRDDLASqGIILKDS 451 Neptuniibacter ...
YP_001340967 376 ASLLAAELRSLAELLGLLy--qDPEYFLQnstvs--eglgeVAIQALIDERTQARKDknFARSDEIRDELASqGIELLDS 451 Marinomonas sp....
ZP_03856430  375 ASTAAGLLRELSALLGLRldsvGGEATEAe-----------PFIDLIVGVRDKLRASriYELSDYIRDKLGElGVSVMDT 443 Thermobaculum t...
ZP_01306025  379 KNPLAALLVELSSILGCLq--sDPDNYLQrgvt-----lddAYIQGKIQERAQAKKDkdFALADKIREDLDAqGIILQDS 451 Oceanobacter sp...
YP_433409    382 ALSLAKGMVDLAEVLGLLq--aDPESLMQgegeev-gglsvAEIEDFIAQRNAARANkdFAESDRIRDLLKEkGVLLNDS 458 Hahella chejuen...
ZP_01894474  353 ANEQAAVLVRLGGVLGLLq--qDPEAFFQadtgg---elsaDDIAAMIQARADARKQkdFAEADRIRDELADkGVILDDS 427 Marinobacter al...
YP_001209134 375 AADIAFTLRTLAARLGLLt--gDAKTLFQqkga-----lsaAEIEAEIARRQAAKAAkdYATADSIREKLSAlGIELKDS 447 Dichelobacter n...
NP_840144    379 DSHYASLLKALGGVLGLLq--qPPQQYLQypahlqdgqysvEEIENMIQQRLQARKErnFAQADTLRQQLAEaGIILEDS 456 Nitrosomonas eu...
YP_544611    372 SAVQAALLKALAGQLGLLq--rDPDEFLKgeava---glspDEIERLIAERLAARKCknFAEADRIRDALTAqGIILEDT 446 Methylobacillus...

Feature 1                
1U0B_B       453 PQGTTWRR 460 Escherichia coli
ZP_01166548  452 REGTSWFR 459 Neptuniibacter caesariensis
YP_001340967 452 REGTTWTR 459 Marinomonas sp. MWYL1
ZP_03856430  444 PEGSKWRL 451 Thermobaculum terrenum ATCC BAA-798
ZP_01306025  452 REGTTWVK 459 Oceanobacter sp. RED65
YP_433409    459 REGTSWQR 466 Hahella chejuensis KCTC 2396
ZP_01894474  428 REGTSWRR 435 Marinobacter algicola DG893
YP_001209134 448 ATGTQWYY 455 Dichelobacter nodosus VCS1703A
NP_840144    457 PQGTTWRR 464 Nitrosomonas europaea ATCC 19718
YP_544611    447 PQGTSWRR 454 Methylobacillus flagellatus KT

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