1GAX


Conserved Protein Domain Family
Anticodon_Ia_Val

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cd07962: Anticodon_Ia_Val 
Click on image for an interactive view with Cn3D
Anticodon-binding domain of valyl tRNA synthetases
This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Statistics
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PSSM-Id: 153416
View PSSM: cd07962
Aligned: 221 rows
Threshold Bit Score: 101.864
Threshold Setting Gi: 19114731
Created: 27-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
anticodontRNA binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Structure:1GAX: Thermus thermophilus valyl-tRNA synthetase binds to the CAC anticodon of its cognate tRNA(Val), contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       #  ## ##                                                          
1GAX_B        567 LDLRWLEMARNFANKLYNAARFVLLSREGfqak--------------edtpTLADRFMRSRLSRGVEEITALYEAlDLAQ 632  Thermus therm...
XP_973688     657 FDVQECHTNRLFCNKIWQATKFTNNAVETarewlgp---------idthqlGLMDRWILSKLSGMVDVCRQGMHNhDFHQ 727  red flour beetle
EEB19582      672 FDFNICYGNRVFCNKIWQSMNYFIKVVNDcnvttendf----ddfvcgqnhTIFDKWIMSKLAGVVKIVDESLNEnRFSI 747  human body louse
XP_316654     649 FNAQEAHTNKLFFNKIWQATRYTLACAERfdagktldqt--vdlrqtadrmPLMDRWILSRLGNTVQQCREAFASyNFHL 726  Anopheles gam...
NP_648268     675 FDVNACHTNKLFLNKVWQAMRFTLGSAKGlgislhqf------etlegvnlGLWDRWIVGRLAETLSVCSQSYSNyNFHL 748  fruit fly
XP_002122808  725 FNLMVAVECRKFFLKIWNIMRFVINLFEHdkfikeqeangklgnietsfqpRAGDVWILSKLCDVIDTTNTHLSNhNVSA 804  Ciona intesti...
NP_505070     589 DVSNAAIEGLHFCNKIWNLAAYYDQLAEKcevik------------dvdsdRLVDEWIMARLSTTVSTVDAHMNKfSLHL 656  nematode
XP_001901624  658 DILQTAEEGLKFCNKLWNLCLYAEEIWRNccevsd-----------qvcsdRLEDCWIRSRLGSSLMMMSEKMDSdCPHL 726  agent of lymp...
XP_002173633  632 VDTQDFEYAHLFVTKLWNIFRFVSIHYSQtkeptf----------kgqttyPVLIRGLRSKIGRLLKSCNDAFSAnKPQD 701  Schizosacchar...
NP_963543     556 INEQKIAGIMKFMNKVWNIANYISQYQYRetq-----------------nlKPTDEWIINYVKYLENKAIEYIRNfEFNK 618  Nanoarchaeum ...
Feature 1                      #   ##  #                                                        
1GAX_B        633 AAREVYELVWSeFCDWYLEAAKPALkagn----------------ahtLRTLEEVLAVLLKLLHPMMPFLTSELYQAL 694  Thermus thermop...
XP_973688     728 VTAAIKEFLYFqFCDVYLETTKRAFklserg------------naaghCWTLTHCLDTALRALAPFMPRLAQHLHQRL 793  red flour beetle
EEB19582      748 ATREIKDFFLNdFCGVYLESTKLTVrensn-------------eckniIYVMHDCLETGFKLLSPFMPFVTEHLYQAM 812  human body louse
XP_316654     727 ATAALKTFFYSnFCDVYLETTKINMkpests------------vaalhCAVLKYCLTVGLRQMEPFTPYLAQELLTHL 792  Anopheles gambi...
NP_648268     749 ATAALKTFFYQyLCDTYLETTKPAIgnrsa-------------dayihVGTLTACLSWGLQAMAPYAPFVASELLQHV 813  fruit fly
XP_002122808  805 AARSLQFFWKEtFSSVYVEYCKSCFtpvineegkgvgyqatndqqiaiAVNILRVAETALRLFSPFAPFLTEELWQRL 882  Ciona intestinalis
NP_505070     657 ALSTLHKFITSdICDIYLESTKKALwnndia------------rireaRSILQRVLQPTLVQLNAFMPFVSEYIYERI 722  nematode
XP_001901624  727 ALSALHRFLYNdLCDVYIETTKKALwlkdys------------rlsvvAEVLHDVIEKSLFHLSIFMPFVSQYLFDRI 792  agent of lympha...
XP_002173633  702 AIPALYDILVNdICNSYVTLSRAAFlnesee------------kqilyVSFLNKALKVILNVAHPLIPQITEVLHSIF 767  Schizosaccharom...
NP_963543     619 LARELYRFVWDvFANHYIELTKKRAknnd----------------dsaIYALYFVFERVLNMLSIFSPGIAKYLAKKL 680  Nanoarchaeum eq...

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