1JZS


Conserved Protein Domain Family
Anticodon_Ia_Ile_ABEc
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cd07961: Anticodon_Ia_Ile_ABEc 
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Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Links
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Statistics
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PSSM-Id: 153415
Aligned: 129 rows
Threshold Bit Score: 154.246
Created: 28-Sep-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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anticodontRNA binding
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Comment:by similarity to other members of this family
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           #  #                                                          
1JZS_A        630 FGPNLVRETVRdYFLTLWNVYSFFVTYANLdrpdlknp-----------pppekrpEMDRWLLARMQDLIQRVTEALEAy 698  Thermus therm...
ZP_03695908   644 FSWEGMQTMEN-HLRTLWNVFRFPLPYMRLdefdpqatt--------vedvqadleLIDEWVLARLQSTKDEMTAHFDEr 714  Natrialba mag...
YP_658388     645 FEWDGLGEMQS-TLNIFWNVFRFPLPYMDLdgydpata----------dlsegsmnIVDEWVLSRLQSVKATTRAAWEEy 713  Haloquadratum...
AAZ32113      617 FDWNTLRENRK-FFVVLSNTYRFFQLYGDKieleev---------------kndlkPEDMWILSKINSLVARVTQLNKEf 680  uncultured eu...
YP_001013594  643 FDPDEVRRYQG-YLNILWNTVKFADTYMELdkwkpkn------------paearlaVEDRWILYRLWQALEKASEAIESd 709  Hyperthermus ...
Q9HN97        645 FSWDETENMQR-DLNILWNVFRFPRPYMALddfdanvpaafggddagvgiadadleTVDEWLLSRLQHVKADATAHWEDf 723  Halobacterium...
Q8ZWU4        643 FDPDEVKYVIG-DLNILWNVVKFADTYMSLdgfdaekyp--------lsqwlekglEEDKWILSELNIMISEFTNFVKNf 713  Pyrobaculum a...
YP_001435603  658 FDPEDIKLAKR-TLDILWNSVKFAKSYMELdkwslekl----------eeglkslePEDSWVLWKLNEYSKRVAEELERs 726  Ignicoccus ho...
YP_001737628  637 FSWKGMEEVSR-KLNIIWNVYVFATTYIGDrdikdld-------------psdvrdPINKWLISRLNTTMKNFREAMEEy 702  Candidatus Ko...
YP_001541014  647 VNPDEFSGIRN-ILTVLWNSVRFADMYMRLdnydprghs--------inevlpkakSEDKWMLSRYFSRLSRITQYLDEf 717  Caldivirga ma...

Feature 1                                                                                         
1JZS_A        699 DPTTSARALRDFVVEDLsQWYVRRNRRRFwknedaldrEAAYATLYEALVLVATLAAPFTPFLAEVLWQNLVRsvrleak 778  Thermus therm...
ZP_03695908   715 RQDKALNALIDFVVEDVsRFYVQAVRERMweeedsaskEAAYATIYRVLRETVALLAPYAPFISEEIYGTLTGda---eh 791  Natrialba mag...
YP_658388     714 EIDTAVNTILEFITDDVsRFYIKAIRERMwadedsaskRGAYATLSTVLDETIRLLAPIAPYLTEQMYQHLNGs-----e 788  Haloquadratum...
AAZ32113      681 RHNRALKEIEYFVVNDLsRTYVKLIRDRTwptyngkdkKAAQAVLYYVLDKVDRLLAPAMPFFTERMYLTVLGgg----k 756  uncultured eu...
YP_001013594  710 NMHQAVQALVDLVVEQVsHRYIPLIRPRVweeemteskDAAYATLYYVLRAVLAAMAPIAPFVTEYLYQAFVRkyepdap 789  Hyperthermus ...
Q9HN97        724 EQHRALDAVLEFVVEDLsRYYVQVVRERMweddasaskTAAYATMQRVLLEVVALLAPYAPFVTEELYSHLTGdr---gy 800  Halobacterium...
Q8ZWU4        714 EFHKAAALWREFVVETLsHRYIRLLRRRVwseepspdkYAAYAVLHDVLKKVLILGSILVPFITEYLWQAYVRkyeknap 793  Pyrobaculum a...
YP_001435603  727 AIHRAAQALQEFIVEVLsHKYITLVRPRVweeeetpskLAAYSALFLALDAAIRMSAPFVPFLAEYLYQRFQRalg-fee 805  Ignicoccus ho...
YP_001737628  703 NLHVASNEIINFLVEDVsHLYLRVSRKKIrskd-eatsSEWISVLYYVLRNAIPYLSVVTPFLAEKIYLDAFMmng--dp 779  Candidatus Ko...
YP_001541014  718 RIHEAAREWISLIVDDVsHGYIRLIRRRVwvegsdddkLVVYTVLYNVLKGAIVIGSVFTPFITEYLYKAFVRda----a 793  Caldivirga ma...

Feature 1                                            
1JZS_A        779 ESVHLADWPEAdpalaDEALVAQMRAVLKVVDLAR 813  Thermus thermophilus
ZP_03695908   792 DTVHMCDWPTVdetfvDEQLEEDVAFLRAIEEAGA 826  Natrialba magadii ATCC 43099
YP_658388     789 TTVHALSYPSVdpewqNETLESEMAVLRDVEEAAA 823  Haloquadratum walsbyi DSM 16790
AAZ32113      757 ESIHLEDWPKInenliDKDLEESMEIIHEITDAAL 791  uncultured euryarchaeote Alv-FOS5
YP_001013594  790 ESIHLNQWPTVpqellDEKAYKAVEEAFAAAEKIL 824  Hyperthermus butylicus DSM 5456
Q9HN97        801 DTVHMADWPTVeeslrAPALEADVAVLRAAEEAGS 835  Halobacterium salinarum
Q8ZWU4        794 ESVHLAQYPAAgs--yDKELIYAYRELFAVFSALA 826  Pyrobaculum aerophilum
YP_001435603  806 ESVHMLQWPEEns-lyDPEEAKAVEELLEAAEKVL 839  Ignicoccus hospitalis KIN4/I
YP_001737628  780 ESVNFLTLPEPnllmiDEELESLMDIVRGIISSSG 814  Candidatus Korarchaeum cryptofilum OPF8
YP_001541014  794 DSVHLAPMPEIrrdliNERLEKAYDAIFEAFSLTA 828  Caldivirga maquilingensis IC-167

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