1WZ2


Conserved Protein Domain Family
Anticodon_Ia_Leu_AEc

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cd07959: Anticodon_Ia_Leu_AEc 
Click on image for an interactive view with Cn3D
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases
This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Statistics
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PSSM-Id: 153413
View PSSM: cd07959
Aligned: 50 rows
Threshold Bit Score: 117.307
Threshold Setting Gi: 20094800
Created: 28-Sep-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
tRNA binding
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:tRNA binding surface [nucleic acid binding site]
Evidence:
  • Structure:1WZ2: The leucyl-tRNA synthetase of Pyrococcus horikoshii OT2 binds its cognate tRNA(Leu), contact at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #  ##  #   #                                              #   #   ##  #  #   
1WZ2_A       689 WRRKEVGKLRKQIERFYELISQFAEYevkgnvelkDIDRWMLHRLNKAIKETTNALEEfrTRTAVQWAfYSIMNDLRWYL 768  Pyrococcus hor...
A4YI28       670 FTEAGARAIADNLKRFYELMQMQDGSti-----dgTPEKWLRSKLHRLVRDVTPLMESmrFREVINELlFNLSSYINEYL 744  Metallosphaera...
NP_342112    662 FSESLVKTVGETLRKMYELFKSLDNYtgd---ilgFPEKWLLSRIYEITSSTTRHMEAleLRDAVNELlFVFSSDLDEYF 738  Sulfolobus sol...
YP_255082    663 FSPNIAKSIGEQLKHIHDFIENLIKLqsvn--eirKVDLWISSLISEYIDLIDNCLSNldLRTAYKTIyYDIYEDLKDYL 740  Sulfolobus aci...
Q4J8J7       658 FSDSYAKSIIDTLKNYYDLLEKLKEFkge---degFPEKWLKSKFYQMVINVTQYMDSldLRSSSNEIlYNFSSYINEYF 734  Sulfolobus aci...
NP_376514    664 FNSNIAKSIAEQLKKIHDLISKLLEIegvn--errDPDVWLLSIFRRYIEDVDKAYENldLRTVYMTVyYTIYETIKDYI 741  Sulfolobus tok...
Q970Z6       660 FSDSYAKSVGEILRRYYEFIKELPKYdge---gseFANNWLKAQVSSIVLSSTKNMDNidFRSTINDIlYSFDSYLREYI 736  Sulfolobus tok...
YP_001013418 646 FSDALARSVMGQLAKFESIAAKALEHddr----vdLVDRWLLSKLQESIEYVTKAMEElrVRSATIHVlYEMENMASKYL 721  Hyperthermus b...
YP_001190672 659 FDVNTVKAVTDQLRRMYDLAVNLSKLrene--stgLPEKWLLSIIHYKVKEVSDLMNSldLRKAFNIIlYEYYEILRDYL 736  Metallosphaera...
NP_342033    655 FNENLVNPIAEQLKKIYDLIDRLLSIntei-kelrTADEWISSKVRDIIEKVNNNITSfkYRDAVNLLlYEIYEILRDYF 733  Sulfolobus sol...
Feature 1        #                                        
1WZ2_A       769 RRtegrddeakrYVLRTLADVWVRLMAPFTPHICEELWEKL 809  Pyrococcus horikoshii OT3
A4YI28       745 EMvrsesreynrDVIREVVETWTKLMAPFAPHLTEEMWHQL 785  Metallosphaera sedula DSM 5348
NP_342112    739 GMvsaegreannKVLREVLTIWLKLITPFAPHLAEEIWHEI 779  Sulfolobus solfataricus P2
YP_255082    741 ELgngk---insDIIKNVISVWIRLMAPFTPHLAEELWHKL 778  Sulfolobus acidocaldarius DSM 639
Q4J8J7       735 ELvrsegrepngKLLSQILQIWIKLLSPFAPHFAEELWHKI 775  Sulfolobus acidocaldarius
NP_376514    742 ELtnak---inkDIIKKVISIWLRLMAPITPHLAEELWHKM 779  Sulfolobus tokodaii str. 7
Q970Z6       737 DMckadgkepngKLLREVIETWIKLLAPFAPHFAEEIWHEL 777  Sulfolobus tokodaii
YP_001013418 722 ELrgg----kpgPALLEYVKTWTKMLAPVAPHLAEEVWHRL 758  Hyperthermus butylicus DSM 5456
YP_001190672 737 SMvsn----pntSVLRKAIEIWARLISPGAPHIAEEIWHIF 773  Metallosphaera sedula DSM 5348
NP_342033    734 DLvei----pnqEVIRKILSIWIRALAPFVPHIAEELWHKI 770  Sulfolobus solfataricus P2

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