2BTE


Conserved Protein Domain Family
Anticodon_Ia_Leu_BEm

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cd07958: Anticodon_Ia_Leu_BEm 
Click on image for an interactive view with Cn3D
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases
This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Statistics
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PSSM-Id: 153412
View PSSM: cd07958
Aligned: 243 rows
Threshold Bit Score: 94.594
Threshold Setting Gi: 162148176
Created: 27-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
tRNA binding
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:tRNA binding surface [nucleic acid binding site]
Evidence:
  • Structure:2BTE: the anticodon binding domain of leucyl tRNA synthetase from Thermus thermophilus binds tRNA(Leu), contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #  ##  #   #                                                                 
2BTE_D       676 WTEEGVQGAWRFLNRIYRRVAEDREAlletsgvf----------------qaealegKDRELYGKLHETLKKVTEDLEAl 739 Thermus thermop...
NP_001099171 668 VKTDAIPGVLRWQSRLWGLVSKLRSVregpetpnp-------------silnkrersEAKKIWDNKNYTLTQVTGHFTEd 734 zebrafish
NP_001085563 677 VKTDAIPGVRRWQTRLWTITSKFIEArnfssvpnp-------------hllnkkevaEARRIWESRNLAVLEVTSHFTEd 743 African clawed ...
NP_056155    680 VKTDALPGVLRWQQRLWTLTTRFIEArasgkspqp-------------qllsnkekaEARKLWEYKNSVISQVTTHFTEd 746 human
YP_325886    605 WTEEGVRSAYTFLTQLKELVAAYAGGdieta---------------------aeadaVAGYIESEREATVAVATEEYEEl 663 Natronomonas ph...
ZP_03695867  626 WSEEGVRSTNAFLTRLKEMVEDFATEqpag-----------------------eddaTARYVANEIDATIAIAGGEYDDl 682 Natrialba magad...
YP_002565039 629 WAEEGVKSTHRFLARLTDLVEEYAAGeaetass------------------dadrdtIDDYVADEVDAAVAIAGAEYDDl 690 Halorubrum lacu...
NP_280869    610 WSEEGVRSSHTFLERLLSMARAVNADatadg----------------------dldpAAEYVARETAATVQAATTHFDDm 667 Halobacterium s...
YP_137387    620 WSPEGVQSAHSFLQNVYTLVSAYAEGeagtatd------------------tengadIADYVAREIDATAANATAEFEDf 681 Haloarcula mari...
YP_658058    612 WSEEGVRSTNQLLTQLIELADVIADInvdravlenhdavtqppisntettltnertpIASYVDTEIDAAVAIATQEYDEl 691 Haloquadratum w...
Feature 1           #   #  ##  #  #   #                                   
2BTE_D       740 -rFNTAIAALMEFLNALYEYRKdrpv-tpvYRTAIRYYLQMLFPFAPHLAEELWHWF 794 Thermus thermophilus
NP_001099171 735 flFNAAISRLMGLTNTLSQASTrvvlhsveFEDALASLCIMAAPMCPHLAPELWAGL 791 zebrafish
NP_001085563 744 ylFNASISQLMSLSNTLSQASSrvilhsseFEDALASLCIMVAPMAPHLASELWKGM 800 African clawed frog
NP_056155    747 fsLNSAISQLMGLSNALSQASQsvilhspeFEDALCALMVMAAPLAPHVTSEIWAGL 803 human
YP_325886    664 -vFNTAVRQAQSFVGTLRQYRShtavhgptFERGLETALKLLAPVAPHICEELWAEL 719 Natronomonas pharaonis DSM 2160
ZP_03695867  683 -tFNRALRETQDLVQTLRQYAAytephaetYERGLSAVVRLLAPVAPHLAEELYAEL 738 Natrialba magadii ATCC 43099
YP_002565039 691 -tFNVALREAQDLVGTLRSYRGhadphpetYERGLDVAVRLLAPVVPHLAEELWETL 746 Halorubrum lacusprofundi ATCC 49239
NP_280869    668 -eFNRAVQAVDELVSLLVRYRDrddaapavVARGVTAAVKLLAPIAPHVAEECWTAL 723 Halobacterium sp. NRC-1
YP_137387    682 -rFNHALQAVRELVSLLRRYQEattpdadtFERGLATAAKLLAPVAPHAAEEMWAEL 737 Haloarcula marismortui ATCC 43049
YP_658058    692 -sFSVALREARDLVQTLRQYRNyttphvdtYRHGLETVIRLLAPVAPHITEELYSAL 747 Haloquadratum walsbyi DSM 16790

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