2CSX,1A8H,1RQG,1P7P


Conserved Protein Domain Family
Anticodon_Ia_Met

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cd07957: Anticodon_Ia_Met 
Click on image for an interactive view with Cn3D
Anticodon-binding domain of methionyl tRNA synthetases
This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Statistics
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PSSM-Id: 153411
View PSSM: cd07957
Aligned: 358 rows
Threshold Bit Score: 103.724
Threshold Setting Gi: 48477614
Created: 27-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
anticodontRNA binding
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Structure:2CSX: Aquifex aeolicus methionyl tRNA synthetase binds the CAU-anticodon of tRNA(Met), contacts at 4 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #   ##  ##  ##  ##                                                      
2CSX_A       340 LNRINGELANEIGNLYSRVVNMAHKFLggevs----gardEEYAKIAQESIKNYENYMEKv----nFYKAIEEILKFTSY 411  Aquifex aeolicus
ABF64929     397 VNKDLADVLGNFVSRITKFCRSKFGEEvpdggt--wgeqeQTLIEELSTRIGAFERHMEAm----eVRKSAQELRAIWVA 470  Silicibacter s...
ZP_01017717  381 VNKDLADVLGNLVNRVTRFTASKFEGQvppgge--pgeaeQTLYREVDDRCAALTGALEAm----eFRKAFAALRGLWAA 454  Parvularcula b...
ZP_00952135  389 VNKDLADVLGNFVNRILKFGASRFEGVipeggt--pgeaeAWLETEVATRLANIASHYEAm----eFRKAAAETRALWAA 462  Oceanicaulis a...
YP_002130050 422 VNADLADVLGNFVNRICKFAESRFEGQvpegge--pgeleTALEADVLMKLRELTGHLEDr----eFRKATTALRQLWVL 495  Phenylobacteri...
YP_757057    389 INSDLANVLGNFVNRITKYTVSKFDGTlpsagt--pgeneAWMAAELDQRLPALVANMEAm----eFRKAAAEVRAIWAA 462  Maricaulis mar...
YP_682760    394 VNKDLADVLGNFVSRITKFCAAKFGSEvpagga--ygsaeLELLTKLDESLTRYQDYMGAm----eVRKSAQELRAIWAS 467  Roseobacter de...
ZP_01741069  393 VNKDLANVLGNFISRITKFCRSKFSEAvpaapldaiaqerAGLWASLAPLIKEYETHMEAm----eVRKSANTLRAIWVV 468  Rhodobacterale...
CAL51681     368 HNADLADVIGNLVHRVTNLCNKSCGGVvpd--------caTEDIFDVLAVRARSEAAMAKf----nIQAACEAAIEAVKA 435  Ostreococcus t...
EEE31304     617 TNAELADTLGNLVHRATSLCVKFCEGKvpp--------vsLPAEGKAPFSIPDTVGEMERlvgqfgLREALEVAMNACRE 688  Toxoplasma gon...
Feature 1            #     #                                            
2CSX_A       412 LNKYVDEKQPWALnkerkkeELQKVLYALVDGLFVLTHLLYPITPNKMKEALQML 466  Aquifex aeolicus
ABF64929     471 GNEYLQSAAPWSVfke-dpeRAAGQVRLGLNLIRLYAVLSAPFIPDASDRLFAAL 524  Silicibacter sp. TM1040
ZP_01017717  455 GNEYLQVTAPWTAfkt-dpdAAAVSVRTALNLIMLIAEVSAPVIPETADKILGIF 508  Parvularcula bermudensis HTCC2503
ZP_00952135  463 GNEYLTRAEPWVHfkt-dkdQAALGVRMGINLVRLCAIVAQPVIPQAAGKILAAL 516  Oceanicaulis alexandrii HTCC2633
YP_002130050 496 GNQYLTEAAPWTAikt-drdRAAVAVRYGLNLAALFAKVSEPFIPFAAEKVSLAL 549  Phenylobacterium zucineum HLK1
YP_757057    463 GNEYLTKAEPWVKyks-dvdAAAVGVRTGLNLVALFGILAQPFIPEAASKILDAL 516  Maricaulis maris MCS10
YP_682760    468 GNEYLQTVAPWSVfkt-dpeTAAMQTRLGLNLALLFGVLSSPFVPDASEKILKCL 521  Roseobacter denitrificans OCh 114
ZP_01741069  469 GNEYLQNTAPWTVnkt-dpeAAAAIVHVSLNLIRLFAVVSSPFIPHAAQQMMDDM 522  Rhodobacterales bacterium HTCC2150
CAL51681     436 TNKYLTDAAPWAVkgegaeeRKAVIIRSTIEAVYVSMHFLQPYIPTACEAIWELK 490  Ostreococcus tauri
EEE31304     689 ANKFLTDWAPWSLtd---stEKQRVVRGALEAVFVLGHLLEPFIPVTADHIFKKL 740  Toxoplasma gondii VEG

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