1F7U,1IQ0,3FNR,2ZUF


Conserved Protein Domain Family
Anticodon_Ia_Arg
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cd07956: Anticodon_Ia_Arg 
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Anticodon-binding domain of arginyl tRNA synthetases
This domain is found in arginyl tRNA synthetases (ArgRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ArgRS catalyzes the transfer of arginine to the 3'-end of its tRNA.
Links
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Statistics
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PSSM-Id: 153410
Aligned: 33 rows
Threshold Bit Score: 168.162
Created: 28-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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anticodontRNA binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Structure:1F7U: Arginyl tRNA synthetase from Saccharomyces cerevisiae binds the anticodon (ICG) of its cognate tRNA(Arg), contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                 #  ##  ##  #                           
1F7U_A       451 DLVGISAVMIQDMQGKRInnyEFKWERMLSFEGD-TGPYLQYAHSRLRSVERNasgi-----tqeKWINADFSLLKepaA 524 baker's yeast
3FNR_A       301 DEIGSDALRYIFLSKKCDthlEFDISDLQKEDSSnPVYYINYAHARIHQVFAKagk------kidDVMKADLQSLNq-dG 373 Campylobacter j...
2ZUF_A       469 EKVGIGAIRYNLIKYSPDkkiIFRWEDVLNFEGE-SAPYIQYAHARCSSILRKaeeegikvdpetLFKNADFTKLSe-rE 546 Pyrococcus hori...
CAJ74695     412 RDVGIGAVIFADLSTKRNkdvIFDWDTVLNFEGE-TGPYVQYTHARLCSILRKyg--------kdVTTDIDYPLLNeddA 482 Candidatus Kuen...
ZP_03211465  411 HEVGVGAVIFHDLKNERLdnfDFNLEEVVRFEGE-TGPYVQYTNARAHSILRKas--------iaPAPEVALSDPA---A 478 Lactobacillus r...
ZP_02211667  413 KQVGVGAVVFQELSNSRIkdyTFSWSRTLSFEGE-TGPYVQYTHARCCAVLRKae--------eeVTADINYDLLSegdG 483 Clostridium bar...
NP_347677    410 RKVGIGAVIFTYLKNGRErdiIFDWKEMLSFEGE-TGPYVQYSYARAKSILRKlg---------eVKGNVSYDKLVsaeE 479 Clostridium ace...
YP_002521789 564 RQVGLGSLKYGMLSRDNNrviVFDIEEALSFEGH-AAPYIQYAHARACRILEKvd--------tlPEGPYALDALTr-eE 633 Thermomicrobium...
YP_001431754 484 EAVGVGAVVYNDLYQDPRrdiRLDWERMLAIEGN-SAPYIQYMHARCCSILRKaade----gvdaEQGDAALLTHPa--E 556 Roseiflexus cas...
ZP_03546111  411 EWTSKDAVRFFLLSRKPDteyTFDVDLAVAQNNDnPVYYVQYAHARIQSVLRAwqeag--gagvpALKDVDLSALEgpqA 488 Comamonas testo...

Feature 1                                                #  ####              #                  
1F7U_A       525 KLLIRLLGQYPDVLRNAIKThePTTVVTYLFKLTHQVSSCYDVLWVAGQte-eLATARLALYGAARQVLYNGMRLLGLTP 603 baker's yeast
3FNR_A       374 VNLLFEALNLKAVLNDAFEAraLQKIPDYLKNLAANFHKFYNENKVVGSa---NENDLLKLFSLVALSIKTAFSLMGIEA 450 Campylobacter j...
2ZUF_A       547 RELVIMLSKFPRIVEQAGKDvkPHLIAWFANELASLFNKFYMDHPVLKAee-gVREARLLLVMAVEQVLKNALYLMGIEA 625 Pyrococcus hori...
CAJ74695     483 IHLIKNLWQYPFVVLKAAQFyePSLVSNYLIDICAGVNKFYNAHRVLSEde-gLTKARILLVDAARQIIKNGLKILGMQA 561 Candidatus Kuen...
ZP_03211465  479 WDVLRALGDYPSIVVRAAKEyePSVIAKYALRLAKAFNKYYANVKVLVEd--sELPARLAMVAATTQVLENALHLLGVAA 556 Lactobacillus r...
ZP_02211667  484 AEVLKVIGSFNKAILAAMRKnePHIITRFVLDLAQAFNKFYHDNPILVDdv-eVRKARLALVAATRQTIENALALLGMHA 562 Clostridium bar...
NP_347677    480 FDLIKQLKGFNGAILNAIDRlePSVITRYVIEVAKAFNKFYNAYNISNTsdeeLKNARLALVEAASIVIKNALSLIGIDV 559 Clostridium ace...
YP_002521789 634 IDLIEQIALFPDEVQRAADEykPLVIANYVYELAKRFNEFYRVCPVLQApe-pQRSARLAIVAAARQTLANGLQLLGIAA 712 Thermomicrobium...
YP_001431754 557 TAVIKQLAKLPGAVREAGERyaPFVIAEWCYETARALSAFYRDCSVLKAetpaLRTARLRLVAATAQALRNGLALLGIKA 636 Roseiflexus cas...
ZP_03546111  489 QALMLLLAKYPEMLTAAAEGnaPHDVTFYLRDLASSYHSYYDAERILVDde-kVKLARLALVAATAQVLHNGLAVLGVSA 567 Comamonas testo...

Feature 1          ##
1F7U_A       604 VERM 607 baker's yeast
3FNR_A       451 KNKM 454 Campylobacter jejuni
2ZUF_A       626 PERM 629 Pyrococcus horikoshii
CAJ74695     562 PVEM 565 Candidatus Kuenenia stuttgartiensis
ZP_03211465  557 PEEM 560 Lactobacillus rhamnosus HN001
ZP_02211667  563 PERM 566 Clostridium bartlettii DSM 16795
NP_347677    560 VEEM 563 Clostridium acetobutylicum ATCC 824
YP_002521789 713 PEVM 716 Thermomicrobium roseum DSM 5159
YP_001431754 637 PERM 640 Roseiflexus castenholzii DSM 13941
ZP_03546111  568 PERM 571 Comamonas testosteroni KF-1

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