1U0B,3C8Z


Conserved Protein Domain Family
Anticodon_Ia_Cys_like
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cd07955: Anticodon_Ia_Cys_like 
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Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC
This domain is found in cysteinyl tRNA synthetases (CysRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. CysRS catalyzes the transfer of cysteine to the 3'-end of its tRNA. The family also includes a domain of MshC, the rate-determining enzyme in the mycothiol biosynthetic pathway, which is specific to actinomycetes. The anticodon-binding site of CysRS lies C-terminal to this model's footprint and is not shared by MshC.
Links
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Statistics
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PSSM-Id: 153409
Aligned: 8 rows
Threshold Bit Score: 108.294
Created: 28-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative tRNA
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative tRNA binding surface [nucleic acid binding site]
Evidence:
  • Structure:1U0B: Escherichia coli cysteinyl tRNA-synthethase binds its cognate tRNA(Cys), contacts at 4 A
  • Comment:The actinomycete MshC protein may not bind to tRNA
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #   #  #  #  #                          # ##  #  ##  #   #                 
1U0B_B       306 EENLKQARAALERLYTALRGTdktvaPAGGEAFEARFIEAMDDDFNTPEAYSVLFDMAREV-NRLKaedmaaANAMASHL 384 Escherichia coli
3C8Z_A       332 NEVLDEANARLARWRSATALPe----APDATDVIARVRQYLADDLDTPKALAALDGWCTDAlSYGGh----dTESPRLVA 403 Mycobacterium s...
ZP_05480064  330 DQLLVDAQERLARWREAVALPa----GPDAEDTVARLRDHLSDDLNTPKALTAIDAWVTSAlRRDGt----dQAAPGLIK 401 Streptomyces sp...
YP_003099989 330 DELFAEAGTRLALWRSAADLEs----GPSVDDVVARVREHLGNDLDTPKALAALDAWAREAwDRGGp----dTEAPGVFR 401 Actinosynnema m...
ZP_04027084  330 DEVLARAQARLDLWRNAFAAAs----SPDGAELVGRLRRYLADDLDTPKALSALDAWAHRAvTSGGp----dPDGPSTVA 401 Tsukamurella pa...
NP_625938    327 DQVLQDALARLDRWRAAVSRPd----GPPAEALVEEIREALANDLDSPAALAAVDRWAALQqESGGt----dIGAPGVVS 398 Streptomyces co...
ZP_04475975  325 ADQLASAEVRLARWRSAVGLPa----GPEAETVLAELRARMTDDLDAPGALAVVDAWADRAlAGGGt----dPGAPALVR 396 Streptosporangi...
YP_289888    328 DADLRTAEQRLERWRAAAAVEn----APDARPLLARVRSALADDLDTATALAAVDEWADAAlSGSGd----dPDAPALMR 399 Thermobifida fu...

Feature 1                 
1U0B_B       385 RKLSAVLGL 393 Escherichia coli
3C8Z_A       404 TTVDALLGV 412 Mycobacterium smegmatis
ZP_05480064  402 EAVDALLGI 410 Streptomyces sp. AA4
YP_003099989 402 TAVDALLGI 410 Actinosynnema mirum DSM 43827
ZP_04027084  402 TAVDALLGV 410 Tsukamurella paurometabola DSM 20162
NP_625938    399 RAVDALLGV 407 Streptomyces coelicolor A3(2)
ZP_04475975  397 DIVDALLGV 405 Streptosporangium roseum DSM 43021
YP_289888    400 TTVDTLLGV 408 Thermobifida fusca YX

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