Conserved Protein Domain Family
ED_3B_like

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cd07952: ED_3B_like 
Uncharacterized class III extradiol dioxygenases
This subfamily is composed of proteins of unknown function with similarity to the catalytic B subunit of class III extradiol dioxygenases. Class III extradiol dioxygenases use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. They play key roles in the degradation of aromatic compounds.
Statistics
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PSSM-Id: 153389
View PSSM: cd07952
Aligned: 14 rows
Threshold Bit Score: 293.057
Threshold Setting Gi: 219408094
Created: 24-Apr-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative metalputative active
Feature 1:putative metal binding site [ion binding site]
Evidence:
  • Comment:based on similarity to other members of the same protein family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #                                                          #              
YP_002577874   4 LAAIVPHGDEILIPEDEESARlhnamiel-------------------gerikekKVDEYIFVSPHHLRIQTHMAIMLTE 64  Aciduliprofundu...
XP_002201862   5 GSVVLPHGTMIFDGDSNSSNEacrqrngalddgmktscsnlykacitageevrrmSPDLVILHTPHGISLSKSVGVFVNP 84  Florida lancelet
ZP_03492723    5 FAAIAPHGFPILPELAGDRPDlmsktraslv---------------vlgqaaqavDPDAFIVITPHGIRAEGQFTISASA 69  Alicyclobacillu...
ZP_01169797    6 FACITPHGGEIIPELQGEKPErmektrksmg---------------rlgalmdkaRPDSLIVLTPHGTRINGQFAVAVSE 70  Bacillus sp. NR...
NP_578341      8 YMAIMPHGNEAVYPIDEDSKIlnanlkk---------------------igeelkDVESYVLITPHNVRSSEAIAIVIAE 66  Pyrococcus furi...
NP_394874      4 RIYVIPHGDEILDRETREDQAmydaik----------------------rytsgdDSDTFVVISPHGIVLDSYIAVTYSK 61  Thermoplasma ac...
NP_111958      4 RIYIIPHGDELIDMDTDEDRKmheaik----------------------kysendDSETLVVISPHGIVLDRDVGVIYSS 61  Thermoplasma vo...
NP_142695      4 GMAVMPHGNEAVYPPDDESRKlnealke---------------------igrrlkDSETYVLISPHNVRISDKLGIIMTE 62  Pyrococcus hori...
YP_023192      4 RIYVIPHGDEIIDMPDKESAEmnkkir----------------------evskndKSDVKLIISPHGLRLENGTVIPMDS 61  Picrophilus tor...
YP_002522888   7 FGAVAPHGFPIIPELSEDAEGglatraamf----------------elgrrcaaaQPDVLVVATPHGVRVDGMVCLALTA 70  Thermomicrobium...
Feature 1                                                                                        
YP_002577874  65 YlEGSWKYKNlr-------------frRKIKCNKDLAWEIYEKtr--ksLPVVGVnf-----gaLEGELSKICLDWGtlI 124 Aciduliprofundu...
XP_002201862  85 TaKGTAEWNDcwd-----------dikLQLPMDKALANQLLTHlgd-sgIDAQGI---------CCFTNYDAPLRWGevV 143 Florida lancelet
ZP_03492723   70 YmEGELSEQTaalmvrayrpdkgnrvhMRRAVDRQLALEIARVaspdlpLAVLNFa-------tADGPLSTLPLDWGtmI 142 Alicyclobacillu...
ZP_01169797   71 RlEGEAAENGss-------------fmMERKTDLMLASSILAEaea-kgLPAAGIny-----gtSAGPLSCLPLDWGaiV 131 Bacillus sp. NR...
NP_578341     67 NlIPWLLFNDvpi-----------pveSEYKTDVELAREIYLSsk--dkFPVVDVnf-----asARGRYSRFPLTWGemI 128 Pyrococcus furi...
NP_394874     62 IiTGYYRTKKhv-------------irKRYENAVDLVDMLASHe----tVQRLRCi--------TLSGNYPCFLDFGslI 116 Thermoplasma ac...
NP_111958     62 KlSGAYRTKHhy-------------irKTYDNDLELADSIARSq----hAQHLRCi--------TLSGNVPCPLDFGtlI 116 Thermoplasma vo...
NP_142695     63 YlIPWLPFNDvhv-----------pseSEYKTDRMLAEKIFKEar--grFPIVDInf-----asAKGRYSRFPLTWGeiI 124 Pyrococcus hori...
YP_023192     62 YyYGYYKTKTrt-------------frSKFRNDLELASLIYKNtsy-itSPGYYIt--------SSGEHSIFPLDFGsiI 119 Picrophilus tor...
YP_002522888  71 RgAGTLRWRGrq-------------ieMNVPLDRAATEAIAGA------ARELGVpvalagfagNRWDQSVIPLDWGtmT 131 Thermomicrobium...
Feature 1                                                                                        
YP_002577874 125 PLYFLPKR--------------------KMVLMTPAReipYESLIDFGKIVGEIVMNs-----KKRIGVIISADHAHAHR 179 Aciduliprofundu...
XP_002201862 144 PLWFIQKNlrn---------------paKYLIMSQSLl-rGEEAVKQRVLVGRALSGfidslsDTRVVVAISGDLAHTHP 207 Florida lancelet
ZP_03492723  143 PLSFMPDR--------------------PVVVIQTARsrpFEEHVRLGRAIRAACDAl-----HRRAAVIASCDWAHAHA 197 Alicyclobacillu...
ZP_01169797  132 PLRFMPEV--------------------PVVVITPSReitYEQHIAFGRAIRKAAGEs-----GRKVGLIASCDWSHTHD 186 Bacillus sp. NR...
NP_578341    129 PLHFLRKK--------------------PLVLISPPRevkREVLVEFGKHLGRVLEGs-----EKEVALIVSADHGHAHD 183 Pyrococcus furi...
NP_394874    117 PLAFFRPK--------------------RIVAMGEPRllsKERIESFSDHLVSVCENy-----TGRISLIISADQAHTHS 171 Thermoplasma ac...
NP_111958    117 PLQFFKRK--------------------RVVAMGEPRlldYSAIVGFADDLYSAMSKf-----ERKISLIISADQAHTHS 171 Thermoplasma vo...
NP_142695    125 PLHFLEKR--------------------EIVLLTPARi-dRNILVEFGRFLGKLLEEe-----EKKIGLIISADHGHAHD 178 Pyrococcus hori...
YP_023192    120 PLSFFKKG--------------------DIISIGQPRincRQKLIEFGNDLYKTLELy-----NKKVSVIISADQSHTHS 174 Picrophilus tor...
YP_002522888 132 PLWFLGHGrnlvghgdvlapppdedigpPVVIVTPSRrlpRERLVTFGEAVALAAERd-----GRRIAFIASCDWAHTHR 206 Thermomicrobium...
Feature 1                                                                                     #  
YP_002577874 180 k------DGPYGYHPDADYYDKYIMENLENLd------------------------------mLLKLKEKTIENAKPDSF 223 Aciduliprofundu...
XP_002201862 208 hscdnplYQPNPRWNMAVEPDAASMFGRCAEgwaksaptdlltsaaegvtasgetwdpviaeqWLRHANELHPKALSCGI 287 Florida lancelet
ZP_03492723  198 e------DGPYGYHKDAARLDAEVERAIAAGdl----------------------------erLADFPDEMIENARPDGM 243 Alicyclobacillu...
ZP_01169797  187 s------EGPYGYHPAAEELDRRTAELIESGrl----------------------------edLALFDPELVENAKPDGI 232 Bacillus sp. NR...
NP_578341    184 p------KGPYGYAKESKEYDSLIYRLMQNMdf----------------------------srLLELENDFIEKAKPDSY 229 Pyrococcus furi...
NP_394874    172 p------DGPYGYSDMSSYYDETVVKSIDSGdf----------------------------saLYRMQQAVIDEAKPDSY 217 Thermoplasma ac...
NP_111958    172 k------DGPYGFSEDADLYDKIVIDSINNNdf----------------------------haLINIDKSIVERAKPDSY 217 Thermoplasma vo...
NP_142695    179 e------KGPYGYAKESEEYDKIITEALKSSnl----------------------------etLLSLDDEFIAKAKPDSY 224 Pyrococcus hori...
YP_023192    175 -------NGIYGYSDLSNVYDNKIISWIKNNdd-----------------------------sIKDLDDNIIERAKPDSY 218 Picrophilus tor...
YP_002522888 207 a------DGPYGFHPDAAEVDRLVVEALEANdp----------------------------grLIELPEEKATNAAIDGL 252 Thermomicrobium...
Feature 1                                                
YP_002577874 224 WQLLILNGILKGn-----pLKLKKKVYGLPTYFGMAVAWY 258 Aciduliprofundum boonei T469
XP_002201862 288 GGFWVLHAMLYSqvergvsFAHKFLAREAPTYYGMMVTLF 327 Florida lancelet
ZP_03492723  244 WQALVLAGAVPKe-----kRHPRVLSYERPTYFGMLCAQM 278 Alicyclobacillus acidocaldarius LAA1
ZP_01169797  233 WQTLILAGAVPEe-----eRHSRLLSFEAPTYFGLICAAY 267 Bacillus sp. NRRL B-14911
NP_578341    230 WSLLIAHGVMQEvk----fSKVVHISYACPTYYGMLSALF 265 Pyrococcus furiosus DSM 3638
NP_394874    218 QNMIMLKRILERt-----gRRMKVRYYYVAKYFGMAFASE 252 Thermoplasma acidophilum DSM 1728
NP_111958    218 QNMIVTARLLEIs-----rRKMHVDYYYVAGYFGMLLARE 252 Thermoplasma volcanium GSS1
NP_142695    225 WSLLIGLGVLKEi-----pMKSSLVTYACPTYYGMASALF 259 Pyrococcus horikoshii OT3
YP_023192    219 WNMLILYGMIKNr------YRLIFKYYYVMDYFSMLLAVA 252 Picrophilus torridus DSM 9790
YP_002522888 253 WQTLMLAGVMRRv-----pLRGEVLCYEAPSYYSMIVAAF 287 Thermomicrobium roseum DSM 5159

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