Conserved Protein Domain Family
ED_3B_N_AMMECR1

?
cd07951: ED_3B_N_AMMECR1 
The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain.
This subfamily is composed of uncharacterized proteins containing an N-terminal domain with similarity to the catalytic B subunit of class III extradiol dioxygenases and a C-terminal AMMECR1-like domain. This model represents the N-terminal domain. Class III extradiol dioxygenases use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon, however, proteins in this subfamily do not contain a potential metal binding site and may not exhibit class III extradiol dioxygenase-like activity. The AMMECR1 protein was proposed to be a regulatory factor that is potentially involved in the development of AMME contiguous gene deletion syndrome.
Statistics
?
PSSM-Id: 153388
View PSSM: cd07951
Aligned: 45 rows
Threshold Bit Score: 135.097
Threshold Setting Gi: 158313079
Created: 24-Apr-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q8R8N9         5 LMPHPPIIVHEVGrge-erKIQKTIDSLENISqeikqkRPDTVIVITPHgyv-------fkdAVSITTLPSLEGdlsqfg 76  Thermoanaerobac...
ZP_05514358    7 VCPCPPLLVPEVAaga-asELDALRAACLDAVaalaaaRPERLIVAGPAehs-------grgPHPQGATGSFRG------ 72  Streptomyces hy...
YP_002783952   7 LVPSPPLLVPELTgaa-aaETAPLRDAVQSAAkal-saIATEWVAVGAA-------------PTAVDVRDDAQGtyrg-- 69  Rhodococcus opa...
ZP_04696701    7 VCPCPPLLVPEVAaga-apELDAARDACLDAVgvlaaaRPDLLVVVGPGdkpagpggnpavgPYPAGAHGTFRG------ 79  Streptomyces ro...
NP_629912      7 VCPCPPLLVPEVAaga-apELDAARAACTDALgvlaasRPDRLVVVGPAdsa-------gpeVYPRDARGSFRG------ 72  Streptomyces co...
YP_482599      8 VCPHPPLLVPEVGr----gEPVEARAVAVDAVrllcaaEPDTIVVVGDA-------------ATEVSYGPAASGsl---- 66  Frankia sp. CcI3
ZP_03863469    8 VCPHPPLLVPEVAsga-aaELDDLRAACFAALdq--laDVDRLVVVGSGp------------TTGTQYDGTAAG------ 66  Kribbella flavi...
ZP_04990914    7 VCPCPPMLVPRIAaga-arELDALRAACGDALsvlaaaRPDRLLVVGPVage-------gsaRHGEGTRGGFHG------ 72  Streptomyces sp...
ZP_04384613    7 LVPSAPLLVPELSgd--saESVQVRAAATTAVsr---lAHEAVHWVGVGvdsekaagelwrsGVGRGQIGTFAG------ 75  Rhodococcus ery...
YP_001505587   8 VCPHPPLLVPQVAgvdpveVRDHAGAAVARLCa----lAPDHIVVVGDDaada------hyaGSAVGSLAGFGVd----- 72  Frankia sp. EAN...
Q8R8N9        77 arevkFKFENDLDLAREIMEEtkkrnIPIAEVseelikkyvlpkklDHGTIVPLYFVTkhy------pdFKLIHMSYGfl 150 Thermoanaerobac...
ZP_05514358   73 -----FGVDVEVRLGGSEVAGs----EAAGGApgr---------plPPSLAVGAWLLEragw---dvapVEGLGVGEPla 131 Streptomyces hy...
YP_002783952  70 -ygvdVRVTLRPGPAGEPDPDlplaaLTAGWIrg----------tcAPDAVVDARILA-----------ADLPPRQCA-- 125 Rhodococcus opa...
ZP_04696701   80 -----VGVNLDVTLGHAPEGV-----TTAGRPl-------------PQSLTVGAWLLGrahwtgapvegLALLPTAAP-- 134 Streptomyces ro...
NP_629912     73 -----FGVDVEVYLGADSGGAgg-aeLPHGLAv------------gAWLLARTGWTDVpv--------dVIGVGEELSa- 125 Streptomyces co...
YP_482599     67 ---agFGVDLRVDLGPTAPAPepssvLSSPALplsi-------tigAWLLGVVGWPGAr---------tAVGVPAEISp- 126 Frankia sp. CcI3
ZP_03863469   67 -----TFGPYGASSVRVGSGPv---vLPLSLTm------------gAWLIGRSKVAGVpr--------tSVTVAADESp- 117 Kribbella flavi...
ZP_04990914   73 -----FGVPVDVRLGRAERSVs----APTADErq----------slPASLAVGAWLLEnv-------awAAAPVSGLAvg 126 Streptomyces sp...
ZP_04384613   76 -----FGADVRTSLDADAAGEp----VPSLELca-----------lVAGWLRGRTDVEit-------ldMHVVSAKASa- 127 Rhodococcus ery...
YP_001505587  73 -----LSFSLGASGTGPAVLPl---sLTIGAWll-----------rEAGWAGRCSARGvpa------atGPAAAAAIG-- 125 Frankia sp. EAN...
Q8R8N9       151 pfEKLYEFGVAIKDAin----ksDRRVVFIASGDLSHkltpnSPNGYTPKGEVFDKTLLQLLSEMKveeVIRMDKDLIEE 226 Thermoanaerobac...
ZP_05514358  132 -pERCIQVGRKLAAS--------AERVALLVMGDGSAcrtlkAPGYLDERAAAFDAEVARALASADtaaLASLDEALAYE 202 Streptomyces hy...
YP_002783952 126 --AYGAELRAFLDRDpe----prGLLIVADGANTLTAk----APGAFDPRAEGVQARVDAALDTGDrdaLLALDPAECAV 195 Rhodococcus opa...
ZP_04696701  135 --EDCAEAGRAVAGR--------ADRVALLVMGDGSAcrtlkAPGYLDDRAAAFDARATEALGSADldaIAALDATLAHE 204 Streptomyces ro...
NP_629912    126 --ERCAAVGRDVAARag----rtALLVLGDASACRTLk----APGYLDERAAPFDAEVGRALETADpaaLAALDPGLARE 195 Streptomyces co...
YP_482599    127 --DGAVALGSRLVAGsapq-erlALLVMGDGSACRTLk----APGGLDPRAAAFDATAAAALAAGDpagLLALDPGLARE 199 Frankia sp. CcI3
ZP_03863469  118 --AGCLALGKELAGSnd----rvGLLVMGDGSARRSEh----SPVHLHPRAEIFDSTIASALALADtttLAALDPDLAAE 187 Kribbella flavi...
ZP_04990914  127 -eENGAEECLALGASlg----dpDERLAVLVLGDGSTtrtvkAPGYLDERAAPWDAVVAKALATADteaLAGLDPVTARA 201 Streptomyces sp...
ZP_04384613  128 --NECREFGQQLRKQldsdnrpqGLLIVADGASTLTAk----APGSFDERAAGVQSAIDDALTAGDpeaLLALDPRLCRS 201 Rhodococcus ery...
YP_001505587 126 --ADLVATAEADGSRl-------ALLIMGDGSARRTVk----APGSLDPRAAAHDASVSAALATLDvtaLLALDPALAAD 192 Frankia sp. EAN...
Q8R8N9       227 AAECGFRSVCVMLGVLDgy------------------eVNAKVLSHEGPFGVGYGVAKF 267 Thermoanaerobacter tengcongensis
ZP_05514358  203 LKAAGRAPLQVLAGAGEga------------------gLKGELRYDEAPYGVGYFVARW 243 Streptomyces hygroscopicus ATCC 53653
YP_002783952 196 LGIGGRVPWQVLAGVFDap------------------pASCRTLYSAAPYGVGYHVGEW 236 Rhodococcus opacus B4
ZP_04696701  205 LKAAGRAPWQLLGGAARda------------------gLAGRLLYEDAPYGVGYTVAAW 245 Streptomyces roseosporus NRRL 15998
NP_629912    196 LKASGRAPWQVLAGAAGds------------------gLGGALLYEDAPYGVGYIVATW 236 Streptomyces coelicolor A3(2)
YP_482599    200 LLAAGRASWQVLAGALLaatrdgpgpaspgpgslgpgsWNSDLRYDDAPYGVGYLVALW 258 Frankia sp. CcI3
ZP_03863469  188 LSAAGRAPWQVLAAVPE---------------------LTGNLLYHAAPYGVGYFVAVW 225 Kribbella flavida DSM 17836
ZP_04990914  202 LGCAGRAPWQVLAGAARgr------------------gLSGSLLLDEAPYGVGYFVAAW 242 Streptomyces sp. SPB74
ZP_04384613  202 VGAQGRAAWQVLAGVFTgssr--------------sahPRATVDYSDAPFGVGYHVGTW 246 Rhodococcus erythropolis SK121
YP_001505587 193 LLAPGRASWQVLAGALRratsg-----------dparsWTSLVRYDDAPFGVGYLVVGW 240 Frankia sp. EAN1pec
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap