1Y7Q,2FI2


Conserved Protein Domain Family
SCAN

?
cd07936: SCAN 
Click on image for an interactive view with Cn3D
SCAN oligomerization domain
The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.
Statistics
?
PSSM-Id: 153421
View PSSM: cd07936
Aligned: 29 rows
Threshold Bit Score: 96.5606
Threshold Setting Gi: 120969705
Created: 30-Sep-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
dimerization
Conserved site includes 37 residues -Click on image for an interactive view with Cn3D
Feature 1:dimerization interface [polypeptide binding site]
Evidence:
  • Structure:1Y7Q: the SCAN domain of human ZNF174 forms a homodimer, contacts at 4 A
    View structure with Cn3D
  • Structure:2FI2: the SCAN domain of the human tumor suppressor protein MZF1 forms a homodimer, contacts at 4 A
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                ## ###    ### ##  ##  ## ####    ##  ##  ### ## ####                  #  
1Y7Q_A          8 PELCRQSFRRFCYqevsGPQEALSQLRQLCRQWLQPe-lHTKEQILELLVMEQFLTILPeEIQARVRHrcLMSSKEIVTL 86   human
XP_688600     231 PETYRQRFRAMSTpageSPTESYHRLRTLYRRWVKPd-sHSKEEIGETIVLEQLLRVLPhEVRMWVKEhePTTGLEAAKL 309  zebrafish
BAB83836      208 AETYRKRFRALDInpgeTPRELYVRLRELFNKWVKPe-aCTVKEISEKLILEQFLRMMNpEMEIWIRErdPQSAEEASRL 286  Japanese medaka
XP_685352     186 AETYRLRFRALNTpsdeSPMELYVRLKDLFSKWVNFk-vSSKTNLMETMVLEQYMRVLYpEVRTWVKErdPVTAEEAAKL 264  zebrafish
A1YFX5         40 SEFSRMVLNSFQDsnnsYARQELQRLYRIFHSWLQPe-kHSKDEIISLLVLEQFMIGGHcNDKAGVKEkwKSSGKNLERF 118  pygmy chimpanzee
NP_001090532   70 PEVYRRKFRALHKepmdSYSDAVSNLRTTFRQWIKGlsiETLADLEDLMVKDQFLHICPaEVRQFVVDrePKTADKAAEI 149  African clawe...
XP_001789345   38 LEVLRVRFRTFSSsdesDPINALRRLRELCGLWLRPd-lHTKEQMVDRLVLEQFVMCMPpDIQVLVKScgAETCKDLEEV 116  cattle
AAI68634      439 PEIHRVKFRDMALkageTFNSFYQRLHYRYDRWMEAsdiKQFKDCYRPLVLEQLLQKCPaIVRQKVLKhkGCSPYQAAQI 518  western clawe...
EDL38120       40 FHSPSVQFNVFPNnngsLAKQELQTLWEMFTSWLQPe-kQTKEQMISQLVLEQFLITGHcKDKYALTEkwKASGRNMERF 118  house mouse
XP_001334195  694 RETYRQRFRSLEVehleSPKELYVRLKELYGKWMQPk-sKSIEEIGEVIILEQYLRMLSpELQVWVREhdPQSASQAATL 772  zebrafish
Feature 1         ## ###
1Y7Q_A         87 VEDFHR 92   human
XP_688600     310 AQQYIN 315  zebrafish
BAB83836      287 AEVFLS 292  Japanese medaka
XP_685352     265 VESYVA 270  zebrafish
A1YFX5        119 IEDLTD 124  pygmy chimpanzee
NP_001090532  150 ADTYAA 155  African clawed frog
XP_001789345  117 LRKKQK 122  cattle
AAI68634      519 ADDHLH 524  western clawed frog
EDL38120      119 MESLTD 124  house mouse
XP_001334195  773 ADVFVA 778  zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap