3EE4


Conserved Protein Domain Family
RNRR2_Rv0233_like

?
cd07911: RNRR2_Rv0233_like 
Click on image for an interactive view with Cn3D
Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain
Rv0233 is a Mycobacterium tuberculosis ribonucleotide reductase R2 protein with a heterodinuclear manganese/iron-carboxylate cofactor located in its metal center. The Rv0233-like family may represent a structural/functional counterpart of the evolutionary ancestor of the RNRR2's (Ribonucleotide Reductase, R2/beta subunit) and the bacterial multicomponent monooxygenases. RNRR2s belong to a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in prokaryotes and archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites.
Statistics
?
PSSM-Id: 153120
View PSSM: cd07911
Aligned: 15 rows
Threshold Bit Score: 317.362
Threshold Setting Gi: 224821994
Created: 28-Aug-2009
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
active sitediiron metal
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3EE4_A; Mycobacterium tuberculosis Rv0233 binds Fe2+ and Mn2+, and myristic acid.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                     #       #   #  #                   
3EE4_A        21 GGLNWASLPLKLFAGGNAk-FWHPADIDFTRDRADWEKLSDDERDYATRLCTQFIAGEEAVTEDIQPFMSAMRAEGrLAD 99  Mycobacterium t...
ZP_04331394   25 GGLNWDSLPLKLFAKGNAr-FWNPADIDLSRDAEDWEGLGEGARARILRLCAFFVAGEEAVTEDIQPFLRAMAAEGrLGD 103 Nocardiopsis da...
ZP_03859820   19 GGFHWDALPLRLFDKGNRk-FWNPRDLDFSQDAEDWQRLTPNEKDNAMMLCAQFIAGEEAVTEDLQPFLQAMAAEGrFGD 97  Kribbella flavi...
YP_001102862  17 GGLNWDSLPLRLFGKGNAk-FWDPADIDFTRDAEDWQGLTEEERRSVAMLCSQFIAGEEAVTQDLQPFMAAMAAEGrFGD 95  Saccharopolyspo...
YP_001636906  11 RGLNRNSPPMRLFEKAKRfgIWNPSLIDLSRDIRDWEQLRDEERDLLLRLTALFQAGEEAVTLDLLPLIRTIAREGrLEE 90  Chloroflexus au...
YP_001433837  12 RGLRRDSVPMRLFEKAKRlgVWNPSDIDFSQDMRDWQTLTDDERDLVLRLTSLFQAGEEAVTLDLLPLVATIAAEGrIEE 91  Roseiflexus cas...
YP_002771093  13 KGFDQELLPYQLYQKAKRygIWNPQDIDFTQDREDYANMNPEQKEETLGRIAGFLGGEEAVTLDLLPLIMVIAEEGrLEE 92  Brevibacillus b...
ZP_04433205   11 GQINWNDPMYKLYEKAKRngGWNPADIDFSQDREDFLQLREEERIASLPLISSFSAGEEAVTLDILPMLHAMARQGrLED 90  Bacillus coagul...
YP_002462374  11 RGLRRNSPPMRLFEKAKQfgIWNPSLLDFSRDIDDWNRLSDEERDLLLRLTALFQAGEEAVTLDLLPLIKAIAHDGrLEE 90  Chloroflexus ag...
YP_148624     12 ATIDWEHPMFKLYEKAKRngKWNPADIDFSQDQKDFASLTSEEKISALPLVAGFSAGEEAVTLDILPMAHALARQGrLED 91  Geobacillus kau...
Feature 1              #   #  #                                  #                               
3EE4_A       100 EMYLTQFAFEEAKHTQVFRMWLDAVGis----edLHRYLDDLPAYRQIFYAELPECLNalsadpspaaQVRASVT-YNHI 174 Mycobacterium t...
ZP_04331394  104 EMYLTQFAFEEARHVQAFRLWLDALGvh----edLHGYVDANPGYRTLFYEELPSSLEalledpsprnQVRASVT-YNHV 178 Nocardiopsis da...
ZP_03859820   98 EMYLTQFCFEEAKHTAVFRLWLDAVGvt----edLHRYVENNPGYRAIFYEALPVALKsladdpspanQVRASVT-YNHV 172 Kribbella flavi...
YP_001102862  96 EMYLTQFCFEEAKHTQVFRLWMDAVGlt----gdLHSHVAENPGYRAIFYEELPRSLNalhddpspanQVRASVT-YNHV 170 Saccharopolyspo...
YP_001636906  91 ELYLTTFLFEEAKHTDFFARFISEVArvdpdlsrYHTASYRALIYEALPAALHRLDHDpsp-----lnLAEASLT-YNMI 164 Chloroflexus au...
YP_001433837  92 ELFLTSFLWEEAKHTDFFNRFLTEVAgvtgdlshYHTANYRALIHEALPAAMERLRDDpsp-----eaQAIASLT-YNMI 165 Roseiflexus cas...
YP_002771093  93 EMFLTTFLFEEAKHTEFFRLVLDNIGesgd-lhhFHDDVYKRIFHEILPNALHRLLTDksp-----eaIAEASTV-YNMF 165 Brevibacillus b...
ZP_04433205   91 TMFLTTFLHDEAKHTEMFSRWQQAVGvgdldlsaYHNDSYKRIFYEALPEAMERLYTDds------peAVIRAATvYNMI 164 Bacillus coagul...
YP_002462374  91 ELFLTTFLFEEAKHTDFFARFISEVArvdpdlsrYHTPSYRALIYDALPRAMQRLEHDpsp-----fnLAEASLT-YNMI 164 Chloroflexus ag...
YP_148624     92 VLFLTTFMHDEAKHVEMFSRWQQAVGigqmdlsvFHNDHYKRIFYEALPEAMNRLYADds------peAVIRAATvYNMI 165 Geobacillus kau...
Feature 1        ##   #  #  #                        #  #                                   #    
3EE4_A       175 VEGMLALTGYYAWHKICVERaILPGMQELVRRIGDDERRHMAWGTFTCRRHVAADdanWTVFETRMNELIPLALRLIEEG 254 Mycobacterium t...
ZP_04331394  179 IEGSLALTGYYAWNHLCTALdVFPGMRRIVRMIGDDERRHMAWGTFTCRRHVAADdanWDVVRDRLDELLPHVTSTVERG 258 Nocardiopsis da...
ZP_03859820  173 VEGTLALTGYHAWNLLCTGRrILPGMQELIRHIGDDERRHMAWGTFTCRRHVAADaanWKVVTDTMEDLLPHALVQIQWA 252 Kribbella flavi...
YP_001102862 171 VEGTLALTGYFAWQKICRSRgILPGMQEVVRRIGDDERRHMAWGTFTCRRHVAADesnWDVVQEQMQHLLPLAVTQIQWR 250 Saccharopolyspo...
YP_001636906 165 VEGVLAETGYHAYFTILDSQdIMPGTREGIRLLKQDESRHIAYGVYLLSRLIATDpqvWDHIVERMNELVLYAMGVIDEI 244 Chloroflexus au...
YP_001433837 166 VEGVLAETGYHAYFTMLERRnLMPGTRKGIGLLKQDESRHIAYGVYLLSRLINAEprlWDVVVERMNELVVYAMGVIDDA 245 Roseiflexus cas...
YP_002771093 166 VEGVLAETGYYAFYEALSKTgLMPGLMQGIGYLKTDESRHISYGTFLLQRLICEHrhiYDVIAKKMDELAPMATHLYDWM 245 Brevibacillus b...
ZP_04433205  165 VEGVLAESGYYSFRQIYKKAgLFPGILQGIDYLNMDEGRHIQFGIYTIQRLVVGNeerFKLFHDYMDELWMHAYGVVEYL 244 Bacillus coagul...
YP_002462374 165 VEGVLAETGYHGYFTILDTHnLMPGVREGIRLLKQDESRHIAYGIYLLSRLIAADrqiWDHIVERMNELVIHALGVIDEI 244 Chloroflexus ag...
YP_148624    166 VEGTLAESGYYTFRQIYKKAgLFPGLLQGIDYLNMDEGRHIQFGIYTIQRIVNEDeryYELFIRYMDELWPHVIGYVDYL 245 Geobacillus kau...
Feature 1        #                      #                                   
3EE4_A       255 Falygd-------qppfDLSKDDFLQYSTDKGMRRFGTISNARGR----PVAEIDVDYS 302 Mycobacterium tuberculosis
ZP_04331394  259 Eepsgdp-----atrryELPPGELVRYAGDRALRRLGAIGSARGV----PVSRIDLDAT 308 Nocardiopsis dassonvillei subsp. das...
ZP_03859820  253 Mensp--------elppEIDPTALMTYAGDRATRRLGAIESALGA----DVAGIDLDYS 299 Kribbella flavida DSM 17836
YP_001102862 251 Pedape-------etpfRLDIDELAAYASDRAGRRLGAISAARGV----PVEQIDVDAS 298 Saccharopolyspora erythraea NRRL 2338
YP_001636906 245 Facyd--------pmpfNLQIETFSTFALNQFQRRLNRLELASRQ----SMNEIDNLAT 291 Chloroflexus aurantiacus J-10-fl
YP_001433837 246 Facye--------vvpfGLSHDDFMQFAMGQFERRLDRIERARNQ----TVEAMEEEAT 292 Roseiflexus castenholzii DSM 13941
YP_002771093 246 Ddpqg--------vsafGVKITDLKQFAKKQLSVRMEVLARAKGQtieeLYKHTRTTID 296 Brevibacillus brevis NBRC 100599
ZP_04433205  245 VglavlqreqsnfesqiVFEPDIMRQYAVKQFHIRKSKIDRARKYk---NLSELEAAAD 300 Bacillus coagulans 36D1
YP_002462374 245 Ftsyd--------tmpfGLQIETFSTFALNQFQRRLNRLELACQQ----SLAEIEGLAT 291 Chloroflexus aggregans DSM 9485
YP_148624    246 Telgkrqqq-lartyalEIDYDLLRHYVIKQFNLRKKQISRTKRVd---VVEGLEKTAA 300 Geobacillus kaustophilus HTA426

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap