2GYQ,2GS4


Conserved Protein Domain Family
YciF

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cd07909: YciF 
Click on image for an interactive view with Cn3D
YciF bacterial stress response protein, ferritin-like iron-binding domain
YciF is a bacterial protein of unknown function that is up-regulated when bacteria experience stress conditions, and is highly conserved in a broad range of bacterial species. YciF has a ferritin-like domain. Ferritin-like, diiron-carboxylate proteins participate in a range of functions including iron regulation, mono-oxygenation, and reactive radical production. These proteins are characterized by the fact that they catalyze dioxygen-dependent oxidation-hydroxylation reactions within diiron centers; one exception is manganese catalase, which catalyzes peroxide-dependent oxidation-reduction within a dimanganese center. Diiron-carboxylate proteins are further characterized by the presence of duplicate metal ligands, glutamates and histidines (ExxH) and two additional glutamates within a four-helix bundle. Outside of these conserved residues there is little obvious homology. Members include bacterioferritin, ferritin, rubrerythrin, aromatic and alkene monooxygenase hydroxylases (AAMH), ribonucleotide reductase R2 (RNRR2), acyl-ACP-desaturases (Acyl_ACP_Desat), manganese (Mn) catalases, demethoxyubiquinone hydroxylases (DMQH), DNA protecting proteins (DPS), and ubiquinol oxidases (AOX), and the aerobic cyclase system, Fe-containing subunit (ACSF).
Statistics
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PSSM-Id: 153118
View PSSM: cd07909
Aligned: 39 rows
Threshold Bit Score: 158.891
Threshold Setting Gi: 171912331
Created: 26-Aug-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
metal bindingdimerization
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:metal binding site [ion binding site]
Evidence:
  • Structure:2GYQ_A; Rhodopseudomonas palustris YcfI binds two Zn2+ ions and one Fe2+ion within the four-helix bundle.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      #                         #   #  #                                
2GYQ_A        14 EDLLLHGLRDIYYAEQQITKALPKMIEQatnRDLSQGLTSHLEETQKQIERLDQVFKklgqkpsgvNCPAIDGLIKEADE 93  Rhodopseudomona...
YP_510150      7 EDLYLEQLRDIYSANMQALDVTDAMARAatdPQLSEALQAGSRGIKGGIDALDRIGKrhdedvgdgHCKGMEGLAKEARA 86  Jannaschia sp. ...
ZP_03850639   36 HQFFVSALKDIYFAENAILDALEKMQEAattEELKDAFEDHHLQTQKHVKRLEKVFQlidekpekkECKAIKGIIEEGEE 115 Chryseobacteriu...
YP_003089929  24 YELFLDCLRDIYWAENHLVKNLPKMSQAassKQLVTAIEQHLAQTVEQVSRLEKIFGlldqktiakKCDAMEGITKEGEG 103 Dyadobacter fer...
ZP_01884274   11 REFLIDGLEDIYDAEEKFVKCFAALGMVavnEELKNMLISHSAITEKHCSRLREICKqlqcnpeegKCVIVDCLLDKAAN 90  Pedobacter sp. ...
YP_008146      6 FEVFTTVLRDLFDVENQLIALLPKMIKEslhPELKSALTTHLNETQNQKKRLQFILEslnantserICKSMRELINEVEE 85  Candidatus Prot...
YP_591932      5 HEMFIHELQDLLDAEQQLVEALGKQAEEssrPDLQKAFQSHQAQTEKQVERLRQCFEsigeeaeevECDGIRGLLKEHDG 84  Acidobacteria b...
ZP_02927801    5 KELFLHQLGSRLSSEMQLVLGMPYVIEEataSTLQSLMLSHHHETVRQIEKLTHVFQafnqpaiatKCEVTAKLIQECHH 84  Verrucomicrobiu...
ZP_00963400   29 KDVYHDQLQDLYSANKQSLDVVVALGRAakdKELSEALIAGSNGISDGMEKIAEICNahgisptgeHCKGMEGLVAEAKA 108 Sulfitobacter s...
ZP_01040654    7 KDLYIDQLQDIYSADKQSLDATKKLHDKatsEELRAALEDGTCGISKGMEKVKGLIQnhdanpngeHCKGMEGLVNEAKA 86  Erythrobacter s...
Feature 1                                #  #   #                                 #           
2GYQ_A        94 TAgei--adkTVLDAAIVANAQAVEHYEIARYGTLIAWAEELGh--------dDIVRFLTTNLNEEKAANTKLNTVA 160 Rhodopseudomonas p...
YP_510150     87 HAieqsfgddAAKDAMIITQYQRLVHYAIAGYGCLAAFAERLEl--------dDDKFALKDCLDASYDGDRTMTDLA 155 Jannaschia sp. CCS1
ZP_03850639  116 VIkate-dgsATRDVALIIAAQKVEHYEIATYGGLAQLAITMGh--------dKAADLLERTLQEEEDTDSLLTDIA 183 Chryseobacterium g...
YP_003089929 104 VIestd-agtATRDVGIILSSQKVEHYEIASYLGLIQLATTLGl--------eEVAGILEESLAEEQASDQLLASIA 171 Dyadobacter fermen...
ZP_01884274   91 LIkrve-tgtALRDVAIVFLIQTIEHYRIATYGNLSSLALEMRy--------fDIHSLLRQCLADEKETDRSLTRIA 158 Pedobacter sp. BAL39
YP_008146     86 IItrfp-tpsSLKDVYLIILCQKIKHYEIASYGSARALARHLSnfsteqidfkEIADTLQYSLDEETRFDETLIDLA 161 Candidatus Protoch...
YP_591932     85 FMeeed-paeDLIDIFNTVAAAKVESYEIQAYQSVIRLADLMGh--------kKASKLLNQSLKEEQQTLKKMEAFS 152 Acidobacteria bact...
ZP_02927801   85 MIhaf--gnsPAINAALAGAAQKIEHLEIASYGSLYEWSLLLRn--------dEATGLLQELLSEERTADQLLIKLA 151 Verrucomicrobium s...
ZP_00963400  109 HAleedygddDVRDAMIITQYQRMVHYALAGYGCLVAFANRLGk--------dEDGAILQECLDQTYDGDRRMTDIA 177 Sulfitobacter sp. ...
ZP_01040654   87 HAinadiddkDVLDASIITQYQRMTHYGLAGYGTAVAFAKRLGl--------eDDSKVLQECLDNTYDGDRRMTSIA 155 Erythrobacter sp. ...

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