Conserved Protein Domain Family
Mn_catalase_like

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cd07908: Mn_catalase_like 
Manganese catalase-like protein, ferritin-like diiron-binding domain
This uncharacterized bacterial protein family has a ferritin-like domain similar to that of the manganese catalase protein of Lactobacillus plantarum and the bll3758 protein of Bradyrhizobium japonicum. Ferritin-like, diiron-carboxylate proteins participate in a range of functions including iron regulation, mono-oxygenation, and reactive radical production. These proteins are characterized by the fact that they catalyze dioxygen-dependent oxidation-hydroxylation reactions within diiron centers; one exception is manganese catalase, which catalyzes peroxide-dependent oxidation-reduction within a dimanganese center. Diiron-carboxylate proteins are further characterized by the presence of duplicate metal ligands, glutamates and histidines (ExxH) and two additional glutamates within a four-helix bundle. Outside of these conserved residues there is little obvious homology. Members include bacterioferritin, ferritin, rubrerythrin, aromatic and alkene monooxygenase hydroxylases (AAMH), ribonucleotide reductase R2 (RNRR2), acyl-ACP-desaturases (Acyl_ACP_Desat), manganese (Mn) catalases, demethoxyubiquinone hydroxylases (DMQH), DNA protecting proteins (DPS), and ubiquinol oxidases (AOX), and the aerobic cyclase system, Fe-containing subunit (ACSF).
Statistics
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PSSM-Id: 153117
View PSSM: cd07908
Aligned: 18 rows
Threshold Bit Score: 154.357
Threshold Setting Gi: 167761937
Created: 27-Aug-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dinuclear metal
Feature 1:dinuclear metal binding motif [ion binding site]
Evidence:
  • Comment:Most diiron-carboxylate proteins have duplicate glutamate and histidine (ExxH) ligands and two additional glutamate ligands within a four-helix bundle.
  • Comment:L chains of vertebrate ferritins and beta-subunits of aromatic and alkene monooxygenase hydroxylases lack diiron ligands.
  • Citation:PMID 8749363

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #                               #  #                
NP_348260     65 PFPPIEvCKCNiryanllyDSYASSGGSELQAITQYIYHHEtif--nkeVSDTLLNIAIVEMRHLDALASLIVKLGGrpa 142 Clostridium ace...
ZP_02086024   53 WYPPVAvLEKNqqya-qilMADLASTASEMTTVHQYLYQSWtindrhqnIRRVIQRIAIVEQHHFSIIGQLIHLLGGqpe 131 Clostridium bol...
ZP_02950784   61 PYPKIQvKNKNekya-qilSQDFCSSVSEFTAISQYINHEIrlknkyckASETILSISKTEMMHMQMIGELITLLGGnls 139 Clostridium but...
ZP_02080600   10 DYPAVEvCGPNpsla-rllNNDLSAAKSEMTAIHQYTYQAWrlekdypeISKTLSEIAMVEMRHFHRLGQLISLLGGtpk 88  Clostridium lep...
YP_001089378  19 PYPEIKvLGPNkyya-ellMDDYAGVSSEFTSVNQYLYHNFdldethreLSEMWINISITEMLHMEILAKTIRLLGGnpv 97  Clostridium dif...
ZP_02420688   19 PYPPVKaARRNprya-emiLPALRAQSSELTAVTTYIYQNWiffkkyssLADTLMKIAKVEMHHMQMLGTLVSLLGGdpr 97  Anaerostipes ca...
ZP_03708708   14 PYPTIRcNGPNprya-qllTIDFASSKGELTAITEYVYQSWmlvpenasAARAMQSVAMVEMHHLDMLGTLIAMLGGnpk 92  Clostridium met...
YP_361081     13 PYPPVKvKNPNtmya-eilMDDYAGTAGELTAITQYLYHHFesektnpqIAKLFEGVALVEMHHLEILAKLIIAFGGnpt 91  Carboxydothermu...
YP_002573615  11 PYPEPKvEEPNrhya-eilLDDYAGYASEFTAIALYSYQHFisdvkhrdFADLIIGIAQVEMKHLDLLGTTIYLLGAlpk 89  Anaerocellum th...
ZP_05393097   16 PYPEPKvEGKNifya-nllLEDYAGMVSELTAINLYIFQHIasegkyddFAELIGGIAMAEMKHLELLGDTIKLLGVkpv 94  Clostridium car...
Feature 1                                                   #                             #  #   
NP_348260    143 ffnsnrdwfstgqlaygenvyklecppckedylcEKLTADLAGEKAAIRGYKdliceisDPKVNAVIEKIISDEQVHARI 222 Clostridium ace...
ZP_02086024  132 crssrpnsyw------------cgnmvsyscelpAILSDNARSEQFAAQAYAaqskeikDPHVSKMLARLSLDEKLHYKI 199 Clostridium bol...
ZP_02950784  140 ysyydngsysy----------wtpkfvefgtnyvNMILLDINDEYKAIRQYEehirvidDMCIRAVLERIIKDEKYHIEL 209 Clostridium but...
ZP_02080600   89 ffsyqrgitlp----------wngkmvdytadihKLLKIDIAAEEAAYITYTrqsqcvkDAKVAANLARIAQDEKLHKAV 158 Clostridium lep...
YP_001089378  98 yrgstsscgay----------wnggfvcygnsicNRLKLDLHLEHVAINNYYkdislieDPYIKAILNRIILDEKLHVSL 167 Clostridium dif...
ZP_02420688   98 faedpcqcw-------------sgdapdytkdlhQALKSNMEAEEAAASFYLetaskiqDPFVCAVLNRIAMDEKVHVQI 164 Anaerostipes ca...
ZP_03708708   93 yrsvssqnirt---------vwtgsmppycrtvrDAMKNNIRAEEEAIATYErhasvirDPAVVAVLNRIIQDEKVHIKV 163 Clostridium met...
YP_361081     92 yrgsfgnnfay----------wsghyvnysqnirEQLIADIHAEKTAIVNYQkhaeiidDPYARPVLYRIIEDEELHLKL 161 Carboxydothermu...
YP_002573615  90 yrgsyttygqy----------wngyfvnydkdlkDMIKIDIQSEKEAIKNYKrhiemidDRYIKKLLERIILDEEKHIKL 159 Anaerocellum th...
ZP_05393097   95 yanstcpfskl----------wtakyvnfttvikAMLAEAIRSEKKAINQYKrhiilikDEFIKKLINRIIIDEELHLKL 164 Clostridium car...
Feature 1             
NP_348260    223 LESFI 227 Clostridium acetobutylicum
ZP_02086024  200 FSDYL 204 Clostridium bolteae ATCC BAA-613
ZP_02950784  210 LTALL 214 Clostridium butyricum 5521
ZP_02080600  159 LNKFL 163 Clostridium leptum DSM 753
YP_001089378 168 FEKAI 172 Clostridium difficile 630
ZP_02420688  165 FRHYL 169 Anaerostipes caccae DSM 14662
ZP_03708708  164 FRSYL 168 Clostridium methylpentosum DSM 5476
YP_361081    162 FKDAL 166 Carboxydothermus hydrogenoformans Z-2901
YP_002573615 160 LKDYL 164 Anaerocellum thermophilum DSM 6725
ZP_05393097  165 LEEMY 169 Clostridium carboxidivorans P7

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