Conserved Protein Domain Family
CYTH-like_CthTTM-like_1

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cd07891: CYTH-like_CthTTM-like_1 
CYTH-like Clostridium thermocellum TTM-like subgroup 1
This subgroup contains the triphosphate tunnel metalloenzyme (TTM) from Clostridium thermocellum (CthTTM) and similar proteins. These are found primarily in bacteria. CthTTM is a metal dependent tripolyphosphatase, nucleoside triphosphatase, and nucleoside tetraphosphatase. It hydrolyzes the beta-gamma phosphoanhydride linkage of triphosphate-containing substrates including tripolyphosphate, nucleoside triphosphates and nucleoside tetraphosphates. These substrates are hydrolyzed, releasing Pi. Mg++ or Mn++ are required for the enzyme's activity. CthTTM appears to have no adenylate cyclase activity. This subgroup consists chiefly of bacterial sequences. These enzymes are members of the CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) superfamily, which have a unique active site located within an eight-stranded beta barrel.
Statistics
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PSSM-Id: 143629
View PSSM: cd07891
Aligned: 77 rows
Threshold Bit Score: 160.746
Threshold Setting Gi: 118470067
Created: 10-Aug-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on similarity to Clostridium thermocellum TTM, where these residues have been shown by mutation analysis to be important for tripolyphosphatase and ATPase activity.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # #                                   # #                                  #   
ZP_04038218    3 REIERKFLV-RSPEWKTg-AAGVLYRQGYLCr-qEARTVRVRIAg------------------------gQAYLTIKGQA 55  Meiothermus rub...
YP_885137      9 FEFERKFFLrELPAVAAsdPSPTLIVQAYLFa-aDGYAVRIRVQqpaptdlgagl----dtflqdlhdesIGTMTAKGPA 83  Mycobacterium s...
ZP_03911603   11 FEFERRFLVrELPATLR--DTPALIVQSYFLs-dGGFALRVRVQasgvearlsassdarevlarhtgqfdFAAVTVKGPS 87  Xylanimonas cel...
YP_002321819   8 FEYERRFFCrELPAEYDdgDAPTLIIQSYYVh-aDNYALRVRLVshkvhvdmtpdvnpvavldeyrdrfsEAYITVKGPS 86  Bifidobacterium...
ZP_01084673    3 LEIERRFLV-GGTGWREhiLWRQHLCQGYLQasaDGVTVRVRLEdgrte----------------aaqgeRAWLTLKATV 65  Synechococcus s...
NP_898358      3 VEIERRFLL-NGEDWRSlaGEPQPLRQGYLAasaEGITVRIRLRga-----------------------eAAWLTLKAAA 58  Synechococcus s...
NP_874573      3 LEIERRFII-KGNEWKAfiKQSQELEQGYFStnfEEWIVRMRMIdr-----------------------kKSQITLKALA 58  Prochlorococcus...
YP_292713      3 IEIERRFLV-ANEDWKDqvIRSESVSQAYLNssvDEWATRVRIIdn-----------------------nKGYITLKSSL 58  Prochlorococcus...
YP_001550057   3 IETERRFLV-KNKEWQVliKKCIKIRQGYLStdfQEWITRIRIInn-----------------------qRSYITIKNSK 58  Prochlorococcus...
YP_001228538   3 LEIERRFFV-VSEAWQElsVKHEQLDQGYLSegqGAVVVRVRRSq------------------------qHAWLTLKAPT 57  Synechococcus s...
Feature 1                # #                      # #            #            # #                
ZP_04038218   56 qg--vTRLEYEYPIPLAEAQELLehLCLKPLIEKTRYCIEfrGRVWEVDEFAGENQGLVVAEVELESPDQPLELPDWVGE 133 Meiothermus rub...
YP_885137     84 vg--gTRYEAERQLDPLVAAEIV--RRAEHVVAKIRYSMWlgEDGWIVDRFLGGNAPLVLAEVERGGPVVDLAIPAFCVS 159 Mycobacterium s...
ZP_03911603   88 vg--gTRYEAERQIEPSVGVELV--RRGGAQILKTRYAAWlgADGWVIDEFGGTNHPLLVAECERSGPVTDLQIPDFCVT 163 Xylanimonas cel...
YP_002321819  87 vg--gTRYEVEREIDTRIAAELI--KRGGSVIIKNRYSVWiaEDGWSVDVFGGPNAPLIVAEAERSGPVTNLTIPKFCIT 162 Bifidobacterium...
ZP_01084673   66 ta--vTRAEFEYAIPVADARQLL--GLAAASLSKERYGLDlpGGDWVLDVFEGENSPLVVAEVELEREDQVLALPAWCHR 141 Synechococcus s...
NP_898358     59 daiglVRHEFEYAIPVADAESLW--TLAPHRLEKTRYQLSlaGGDWVVDHFAGRNGPLLLAEVELPAAQTPLEIPSWCGQ 136 Synechococcus s...
NP_874573     59 gk--mSTHEFEYSIPLEDAVFMW--NLISKKLKKKRYFLNfgPGSWVVDCFEGSNFPLVLAEVELNSEKVLFEQPSWCSQ 134 Prochlorococcus...
YP_292713     59 ng--lANYEFEYSIPRKDAIELI--QLSKYKITKIRYQLKinKKNWVVDVFEESNSYLKIAEIELNSESEEIQVPSWCGK 134 Prochlorococcus...
YP_001550057  59 gg--mQSHEFEYKIPIHDAESIW--HLLNYKLIKQRYLLDlnPGSWVVDCFKNENSPLVIAEVELEAPELDVMIPDWCGK 134 Prochlorococcus...
YP_001228538  58 nn-peIRQEFEYTIPAADAKALL--ALTPRRVEKTRHHLNcpGGDWVVDVFAGANAPLVIAEVERSDPEAQLTIPSWCGE 134 Synechococcus s...
Feature 1                         
ZP_04038218  134 EVTHDPRYLNASLVEHP 150 Meiothermus ruber DSM 1279
YP_885137    160 EVSEDDRFRNEYLAFQP 176 Mycobacterium smegmatis str. MC2 155
ZP_03911603  164 ELTDDRRFSNESLAVDP 180 Xylanimonas cellulosilytica DSM 15894
YP_002321819 163 EITDQARFNNDGLANRP 179 Bifidobacterium longum subsp. infantis ATCC 15697
ZP_01084673  142 EITGLGALSNAALARRP 158 Synechococcus sp. WH 5701
NP_898358    137 EITGDGRWSNAALARRP 153 Synechococcus sp. WH 8102
NP_874573    135 EVTGIKKLSNASLAQYP 151 Prochlorococcus marinus subsp. marinus str. CCMP1375
YP_292713    135 EITGIKSLSNASLAKAP 151 Prochlorococcus marinus str. NATL2A
YP_001550057 135 ELTGQKQWSNAALAKFP 151 Prochlorococcus marinus str. MIT 9211
YP_001228538 135 EITGRGELSNAALAMRP 151 Synechococcus sp. RCC307

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