1BVO


Conserved Protein Domain Family
RHD-n_Dorsal_Dif

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cd07887: RHD-n_Dorsal_Dif 
Click on image for an interactive view with Cn3D
N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the arthropod Dorsal and Dif (Dorsal-related immunity factor), and similar proteins. Dorsal and Dif are Rel-like transcription factors, which play roles in mediating innate immunity in Drosophila. They are activated via the Toll pathway. Cytoplasmic Dorsal/Dif are inactivated via forming a complex with Cactus, the Drosophila homologue of mammalian I-kappa B proteins. In response to signals, Cactus is degraded and Dorsal/Dif can be transported into the nucleus, where they act as transcription factors. Dorsal is also an essential gene in establishing the proper dorsal/ventral polarity in the developing embryo.
Statistics
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PSSM-Id: 143647
View PSSM: cd07887
Aligned: 5 rows
Threshold Bit Score: 305.181
Threshold Setting Gi: 189236479
Created: 10-Aug-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   # ## ## ####                                                      
1BVO_A      1 PYVEITEQPHPKaLRFRYECEgRSAGSIPGVNTTa-eQKTFPSIQVHGYRGRAVVVVSCVTKEGPeHKPHPHNLVGKe-- 77  African malaria mo...
XP_974806   4 PYIRIIEQPQKS-LRFRYQCE-KRTGNIPGASSTs-tLKTVCAIQIVGYQGRAAVVVSCVTKDEP-HKPHPHKLVGE--- 76  red flour beetle
AAZ40333   19 PYVRLVEQPASRaLRFRYECEgRSAGSIPGANSTa-eCKTYPTIQVVNYKGSAVVVVSCVTKEGPpFRPHPHNLVGRe-- 95  Southeast Asian ho...
P98149     78 PHLRIVEEPTSNiIRFRYKCEgRTAGSIPGMNSSsetGKTFPTIEVCNYDGPVIIVVSCVTSDEP-FRQHPHWLVSKeea 156 fruit fly
Q962A4     83 IYVEIVEQPKQRgLRFRYECEgRSAGSIPGEGSTs-eKKTFPTIKIHNYTGTAVIVVSCVTKDQP-YEPHPHNLVGR--- 157 Pacific oyster
Feature 1                                  # ###                                #             
1BVO_A     78 -GCKKGVCTVEINSt--tMSYTFNNLGIQCVKKKDVEEALRLRQEIrVDPFRTGFGHAKEPGSIDLNAVRLCFQVFLegq 154 African malaria mo...
XP_974806  77 -HCKKGVYTFEAEItpnnPDIVFRKLGVQCVKRNELKESLNVREEKnIDPFKTGFSHKDHLNCIDLNVVRLCFQVFLide 155 red flour beetle
AAZ40333   96 -GCKKGICTMVINNh--dMTCSFSSLGIQCVKRKDIEESLKLREMIkVDPYRTGFDHRLQTSNIDLNVVRLCFQVFIegp 172 Southeast Asian ho...
P98149    157 dACKSGIYQKKLPPe--eRRLVLQKVGIQCAKKLEMRDSLVERERRnIDPFNAKFDHKDQIDKINRYELRLCYQAFItvg 234 fruit fly
Q962A4    158 -DCKRGVCTLKVKDt---NVISFPHLGIQCAKKKDVENNLKQRKEInVDPFQSGFKHLNKINSIDLNVVRLCFQVFLpde 233 Pacific oyster
Feature 1                        # 
1BVO_A    155 qrgrftEPLTPVVSDIIYDKK 175 African malaria mosquito
XP_974806 156 n-grftSGLAPVVSEPIYNRK 175 red flour beetle
AAZ40333  173 qqgkytVPLPPVVSDPIFDKK 193 Southeast Asian horseshoe crab
P98149    235 ---nskVPLDPIVSSPIYGKS 252 fruit fly
Q962A4    234 n-gkitRIVPPVVSHCIHDKK 253 Pacific oyster

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