3DO7


Conserved Protein Domain Family
RHD-n_RelB

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cd07886: RHD-n_RelB 
Click on image for an interactive view with Cn3D
N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein
Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.
Statistics
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PSSM-Id: 143646
View PSSM: cd07886
Aligned: 4 rows
Threshold Bit Score: 290.222
Threshold Setting Gi: 47225027
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:3DO7_A: Human RelB/NF-kappa B2 (p52) heterodimer binds DNA, only the RelB and DNA strands are shown, contacts at 4A
    View structure with Cn3D
  • Structure:3DO7: Human RelB/NF-kappa B2 (p52) heterodimer binds DNA, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   # ## ## # # #                                                     
3DO7_A     16 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTQPAIELRDCGGl-rEVEVTACLVWKDWPhRVHPHSLVGKDC 94  house mouse
P51510     78 PELNITEQPKQRGMRFRYQCEGRSTGSILGEKSTEHNKTLPEIEIINCDGl-eEIHVIVCLVWRDPPhRVHPHGLVGKDC 156 African clawed frog
P51509    138 PRLIITEQPKKTGMRFRYECEGRSAGSILGESSTEASKTLPAIELLNCQAi-pEVQVTACLVWKDWPhRVHPHGLVGKDC 216 chicken
CAF97442    2 PRLLVVEEPKQRGMRFRYECEGRSAGSILGASSTETNKTQPAVEIQGPIErlkKVTLTVSLVTKDPPhRPHPHCLVGKDC 81  spotted green puff...
Feature 1                                   ###                                               
3DO7_A     95 TD--GVCRVRLRPHVS-PRHSFNNLGIQCVRKKEIEAaierk----------------------------iqlgIDPYNA 143 house mouse
P51510    157 HN--GICEVTLNPQNGvAKHSFSNLGIQCVRKREIDSavner----------------------------lklnIDPYKA 206 African clawed frog
P51509    217 SN--GLCQVRLQPHAN-PRHSFSNLGIQCVKKKEIEAaiekk----------------------------lqlgIDPFKA 265 chicken
CAF97442   82 PEgsGICQVTINPHSS-RRHRCRPGVSRSPSHRWRGPvshtrpsfclcsfanlgiqcvrrkeldvslqkrrsqnIDPFQT 160 spotted green puff...
Feature 1                                                 
3DO7_A    144 GSLKnhqEVDMNVVRICFQASYrdqqghlHRMDPILSEPVYDKK 187 house mouse
P51510    207 GKWRlheEVDLNVVRLCFQASCtgp-gfkYDIPPVLSDPIYDKK 249 African clawed frog
P51509    266 GSLKnhqEVDMNVVRICFQASYrdgsgrtRQLSPVLSEPIFDKK 309 chicken
CAF97442  161 GDSKgieDMDMNAVRLCFQCELewddgrkDCLSPVVSSPIYDKK 204 spotted green pufferfish

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