1VKX,2O61


Conserved Protein Domain Family
RHD-n_RelA

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cd07885: RHD-n_RelA 
Click on image for an interactive view with Cn3D
N-terminal sub-domain of the Rel homology domain (RHD) of RelA
Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD domain of the RelA family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelA (also called p65) forms heterodimers with NF-kappa B1 (p50) and B2 (p52). RelA also forms homodimers.
Statistics
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PSSM-Id: 143645
View PSSM: cd07885
Aligned: 5 rows
Threshold Bit Score: 330.679
Threshold Setting Gi: 190338173
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   # ## ## ####                                                      
1VKX_A      1 AYVEIIEQPKQRgMRFRYKCEgRSAGSIPGERSTDTTKTHPTIKINGYTgPGTVRISLVTKDPPHRPHPHELVGKDCRdG 80  house mouse
Q04865     18 PPVEIIEQPKQRgMRFRYKCEgRSAGSIPGERSTDTSKTHPTIKINNYQgPARIRISLVTKDSPHKPHPHELVGKDCKdG 97  African clawed frog
2O61_A      2 GYVEIIEQPKQRgMRFRYKCEgRSAGSIPGERSTDTTKTHPTIKINGYTgPGTVRISLVTKDPPHRPHPHELVGKDCRdG 81  human
NP_990460  25 PFVEILEQPKQRgMRFRYKCEgRSAGSIPGEHSTDSARTHPTIRVNHYRgPGRVRVSLVTKDPPHGPHPHELVGRHCQhG 104 chicken
AAI62910   18 PHVEIIEQPKSRgMRFRYKCEgRSAGSIPGEKSNDTTKTHPAIRVHNYSgPVRVRISLVTKNQPYKPHPHELVGKDCKhG 97  zebrafish
Feature 1                            ###                                                      
1VKX_A     81 YYEADLCpDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFHVPIEeq-rgDYDLNAVRLCFQVTVRdpa-grpLLLT 158 house mouse
Q04865     98 YYEAELSpDRSIHSFQNLGIQCVKKREVEDAVAHRIRTNNNPFNVSPEel-kaDYDLNTVCLCFQVFIPdqaagrmLPLP 176 African clawed frog
2O61_A     82 FYEAELCpDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEeq-rgDYDLNAVRLCFQVTVRdps-grpLRLP 159 human
NP_990460 105 YYEAELSpERCVHSFQNLGIQCVKKRELEAAVAERIRTNNNPFNVPMEer-gaEYDLSAVRLCFQVWVNgpg--glCPLP 181 chicken
AAI62910   98 YYEADLQ-ERRIHSFQNLGIQCVKKKDVGEAVSCRLQTQNNPFKIPDAkiweeEFDLNAVRLCFQVSITlss-gdlFPLE 175 zebrafish
Feature 1               #
1VKX_A    159 PVLSHPIFDNR 169 house mouse
Q04865    177 FVVSQPIYDNR 187 African clawed frog
2O61_A    160 PVLSHPIFDNR 170 human
NP_990460 182 PVLSQPIYDNR 192 chicken
AAI62910  176 PVVSQPIYDNR 186 zebrafish

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