Conserved Protein Domain Family
RHD-n_Relish

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cd07884: RHD-n_Relish 
N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Relish
Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the arthropod Relish protein, in which the RHD domain co-occurs with C-terminal ankyrin repeats. Family members are sometimes referred to as p110 or p68 (proteolytically processed form). Relish is an NF-kappa B-like transcription factor, which plays a role in mediating innate immunity in Drosophila. It is activated via the Imd (immune deficiency) pathway, which triggers phosphorylation of Relish. IKK-dependent proteolytic cleavage of Relish (which involves Dredd) results in a smaller active form (without the C-terminal ankyrin repeats), which is transported into the nucleus and functions as a transactivator.
Statistics
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PSSM-Id: 143644
View PSSM: cd07884
Aligned: 7 rows
Threshold Bit Score: 225.772
Threshold Setting Gi: 85718022
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DNA binding
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      # ## ##  ####                                                      
Q94527        150 PQLRIVEQPVEKFRFRYKSEmhGTHGSLNGAns-krTPKTFPEVTLCNYDg---PAVIRCSLFQTNl----dSPHSHQLV 221  fruit fly
Q8MV44        133 PQLTIVEQPVDKFRFRYQSEmhGTHGSLMGVht-ekSKKTFPTVQLHGFQg---EAKIRCSLFQVDpn--rrAAHSHNLV 206  yellow fever ...
XP_970894      59 PFLRIIEQPIDRFRFRYKSEmtGTHGSLCGQnsdrsRKQTYPTIELCNFYk---RAVVRCSIYQYNtke-dqKPHPHRLI 134  red flour beetle
XP_001602212   16 PQLKIVVQPVDKFRFRYKSEmmGTHGSLLGEreetsHKKEVPTAQLINCHl--pEAVIRCTLVTADed--rrFPHAHHLV 91   jewel wasp
NP_001095935   52 PFLRIIEQPQDYFRFRYASEmaGTHGCLLGKssstnKNKVHPTVELVNYTg---QAVIKCQLAQHKt----pEEHPHKLF 124  domestic silk...
ABC75034      136 PYLSVLEQPTNRIRYRYKSEk-GSHGGLTGEfs-ssSKKTYPTVKLENYRpqnnQVFIKATLYTVDdq---qKPHVHKLM 210  Southeast Asi...
ABR14713       50 AFIQILEQPQSKFRFRYKSEmvGTHGQLKADrs-dkNKAVFPTVKLAKWNh--gPAVIRLMLYTAEdninqrKRHVHELS 126  Pacific white...
Feature 1                                           # ##                                          
Q94527        222 VRkDDR--DVCDPHDLhvskerGYVAQFINMGIIHTAKKYIFEELCKKkqdrlvfqmnrrels-----------hkqlqe 288  fruit fly
Q8MV44        207 IKsGEI--DLNDPHDIdvneecNYVAMFQGMGIIHTAKKNIAEELSKKmkkqrsvemnreltl------------reeyq 272  yellow fever ...
XP_970894     135 KKqGKG--EVDDPHDAyvspedGYVYTFHSMGIIHTAKKNLVPELVKKktqlkkeevarlegkmre------ltqkeeie 206  red flour beetle
XP_001602212   92 KKdGNS--DKDDPHDInvsrenNYTAMFCNMGIIHTAKKNIKEEIMRKrkievmeekkrknfenpv------istredle 163  jewel wasp
NP_001095935  125 EEeQDN--DDREVSCIvpk-qgIYKVGFGGMGIIHTAKKNVPGLLFQKyaekcknisnk--------------------e 181  domestic silk...
ABC75034      211 GKhCQD--GVCSVILGe-----DMVASFQNLGILFVGKKEVPDILYKKkledqhllrclmqngslh------iteadknq 277  Southeast Asi...
ABR14713      127 GKqCCKetGICEVVVDek---vDYTAVFQNLGIIHIAKRDTKDIILQRkkeelitharlrkphlsyedirrsitqsdnkr 203  Pacific white...
Feature 1                                                         #
Q94527        289 lhqetereaKDMNLNQVRLCFEAFKiedn-gawVPLAPPVYSNAINNRK 336  fruit fly
Q8MV44        273 lqkeaaemaKTMNLNQVCLCFQAFQvdastgrwAQLCEPVYSNPINNMK 321  yellow fever mosquito
XP_970894     207 ikglaeaesKFINLNVVVLRFDAFYenn--gilHPICPPVYSHTINNLK 253  red flour beetle
XP_001602212  164 mkmeaekaqKWMNLNSVALCFQGFApgan-dvlIPITEKVYSRPINNLK 211  jewel wasp
NP_001095935  182 lkiqcenmaKSIDLNIVRLKFSAHDis----tdREICKPVFSEPIHSLK 226  domestic silkworm
ABC75034      278 lkkdaeqeaKNMDLNRVKIRFEAFAvsq--ghlYPICDAVFSNIIANQK 324  Southeast Asian horseshoe crab
ABR14713      204 meeeaeeeaKNMDLNKVVLRFQAFQydkkiesyRPVTLPVDSDIVYNLK 252  Pacific white shrimp

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