1IMH


Conserved Protein Domain Family
RHD-n_TonEBP
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cd07882: RHD-n_TonEBP 
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N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.
Links
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Statistics
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PSSM-Id: 143642
Aligned: 7 rows
Threshold Bit Score: -1
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #  # ######                                                        
1IMH_C         17 KELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNePVVLQVFVGNDSg-RVKPHGFYQACRVTGRNTTPCK 95   human
Q9GU53        255 VQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIVRLTGYDkVAVLQVFIGTDIg-RVAPHMFYQACKVAGKNSTQCN 333  fruit fly
BAG70407      204 KELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNePVVLQVFVGNDSg-RVKPHGFYQACRVTGRNTTPCK 282  chicken
XP_002214870   15 MQLKILKQPEVHHRARYMTEGSRGSVKDESGHGFPTVKLEGCNkSATLQVFVGTDTg-KIKPHGFYQACKVTGRNTTPCT 93   Florida lancelet
NP_956189     266 KELKILVQPETQHRARYLTEGSRGSVKDRTQQGFPTIKLDGVSdPVVLQVFVANDAg-RVKPHGFYQACRVTGRNTTACK 344  zebrafish
XP_002120942  346 CSLSIVNQPEPQHRARYLTEGSRGPVKDSSQQGYPQIELKGYTgKTTLLVYVGSESddKIRPHGFYQACKVTGRNTTACE 425  Ciona intesti...
XP_001177692  228 GEIHITVQPEKHHRARYRTEGSRGSVKDDSGENFPKLKLLGINqQVLLQVFVVTDQg-KVRPHGYYQACKVTGRNTTPSE 306  purple urchin
Q9GU53        255 VQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIVRLTGYDkVAVLQVFIGTDIg-RVAPHMFYQACKVAGKNSTQCN 333  fruit fly
BAG70407      204 KELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNePVVLQVFVGNDSg-RVKPHGFYQACRVTGRNTTPCK 282  chicken
XP_002214870   15 MQLKILKQPEVHHRARYMTEGSRGSVKDESGHGFPTVKLEGCNkSATLQVFVGTDTg-KIKPHGFYQACKVTGRNTTPCT 93   Florida lancelet
NP_956189     266 KELKILVQPETQHRARYLTEGSRGSVKDRTQQGFPTIKLDGVSdPVVLQVFVANDAg-RVKPHGFYQACRVTGRNTTACK 344  zebrafish
XP_002120942  346 CSLSIVNQPEPQHRARYLTEGSRGPVKDSSQQGYPQIELKGYTgKTTLLVYVGSESddKIRPHGFYQACKVTGRNTTACE 425  Ciona intesti...
XP_001177692  228 GEIHITVQPEKHHRARYRTEGSRGSVKDDSGENFPKLKLLGINqQVLLQVFVVTDQg-KVRPHGYYQACKVTGRNTTPSE 306  purple urchin

Feature 1                                        # ##                 # #                         
1IMH_C         96 EVDIEGTTVIEVGLDPs-nNMTLAVDCVGILKLRNADVEARIgia---gsKKKSTRARLVFRVNIMRkd-----gSTLTL 166  human
Q9GU53        334 EKKVDGTMVIEIDFKPe-tDMTITCDCVGILKERNVDVEHRFpehlaqknKKKSTRCRMVFRTQLTRdd-----gTTETL 407  fruit fly
BAG70407      283 EVDIEGTTVIEVGLDPs-nNMTLAVDCVGILKLRNADVEARIgia---gsKKKSTRARLVFRVNITRkd-----gSTLTL 353  chicken
XP_002214870   94 ERDIEGTTVIEVPLDPt-nNMTQSLDCVGILKLRNADVEARIgla---rsKRRSTRCRLVFRVHIPRed-----gSLLTL 164  Florida lancelet
NP_956189     345 EVDIEGTTVIEVNLEPt-nSMTLPVDCVGILKLRNADVEARIgva---gsKKKSTRARLAFRVNIPRpd-----gSILTL 415  zebrafish
XP_002120942  426 EVEVEGTKVIHIPFDA---QEIISVDCVGILKLRNADVEARIgis---raKKRSQTVRLVFRVILNDiersdgctPPLVL 499  Ciona intesti...
XP_001177692  307 EKDVEGTTVLEVPWEPvdgKMEISVDCIGILKLRNADVEQRIgpl---rsKRKSTCVRLAFRVIVPAsd-----gSFNVV 378  purple urchin
Q9GU53        334 EKKVDGTMVIEIDFKPe-tDMTITCDCVGILKERNVDVEHRFpehlaqknKKKSTRCRMVFRTQLTRdd-----gTTETL 407  fruit fly
BAG70407      283 EVDIEGTTVIEVGLDPs-nNMTLAVDCVGILKLRNADVEARIgia---gsKKKSTRARLVFRVNITRkd-----gSTLTL 353  chicken
XP_002214870   94 ERDIEGTTVIEVPLDPt-nNMTQSLDCVGILKLRNADVEARIgla---rsKRRSTRCRLVFRVHIPRed-----gSLLTL 164  Florida lancelet
NP_956189     345 EVDIEGTTVIEVNLEPt-nSMTLPVDCVGILKLRNADVEARIgva---gsKKKSTRARLAFRVNIPRpd-----gSILTL 415  zebrafish
XP_002120942  426 EVEVEGTKVIHIPFDA---QEIISVDCVGILKLRNADVEARIgis---raKKRSQTVRLVFRVILNDiersdgctPPLVL 499  Ciona intesti...
XP_001177692  307 EKDVEGTTVLEVPWEPvdgKMEISVDCIGILKLRNADVEQRIgpl---rsKRKSTCVRLAFRVIVPAsd-----gSFNVV 378  purple urchin

Feature 1                   #
1IMH_C        167 QTPSSPILCTQ 177  human
Q9GU53        408 QVCSNPIICTQ 418  fruit fly
BAG70407      354 QTPSSPILCTQ 364  chicken
XP_002214870  165 QCHSTPIICSE 175  Florida lancelet
NP_956189     416 QTLSSPILCTQ 426  zebrafish
XP_002120942  500 QVVSNRINCTQ 510  Ciona intestinalis
XP_001177692  379 QTVSRSITCTQ 389  purple urchin
Q9GU53        408 QVCSNPIICTQ 418  fruit fly
BAG70407      354 QTPSSPILCTQ 364  chicken
XP_002214870  165 QCHSTPIICSE 175  Florida lancelet
NP_956189     416 QTLSSPILCTQ 426  zebrafish
XP_002120942  500 QVVSNRINCTQ 510  Ciona intestinalis
XP_001177692  379 QTVSRSITCTQ 389  purple urchin

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