1OWR,1A66,1P7H


Conserved Protein Domain Family
RHD-n_NFAT

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cd07881: RHD-n_NFAT 
Click on image for an interactive view with Cn3D
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development.
Statistics
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PSSM-Id: 143641
View PSSM: cd07881
Aligned: 15 rows
Threshold Bit Score: 367.6
Threshold Setting Gi: 125806437
Created: 31-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                #  # ## ###                                              
1OWR_M          4 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMenkPLGLQIFIGTADERilKPHAFYQVH 83   human
1P7H_M          6 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMenkPLGLQIFIGTADERilKPHAFYQVH 85   human
CAK04364      350 DWQLPSSSGPYSLQIDVQPKSHHRAHYETEGSRGAVKALAGGHPVVQLHGYMesePLTLQLFIGTADDRllRPHAFYQVH 429  zebrafish
XP_417509     398 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMenkPLGLQIFIGTADERilKPHAFYQVH 477  chicken
XP_700591     325 DWPLPCSSGQYELRIEAQPRQHHRAHYETEGSRGAVKASSGGHPVVQLRGYTgtePLVLQIFIGTADDRnlRPHAFYQVH 404  zebrafish
XP_690183     258 DWPLPSQFDQYELRIEVQPRPHHRAHYETEGSRGAVKASPGGHPVVKLVGYTerqPLSLQVFVGTADDRsiRPHPFYQIH 337  zebrafish
NP_001129494  470 DWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLGYSe-kPLTLQMFIGTADERnlRPHAFYQVH 548  human
NP_001135546  407 DWALPSRYGQYELKVDVQPKTHHRAHYETEGSRGAVKAVTGNHPIVKLTGYTe-kPLNLQMFIGTADDRyvRPHAFYQVH 485  western clawe...
P97305        421 DWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSe-kPINLQMFIGTADDRylRPHAFYQVH 499  house mouse
XP_414078     543 DWPLPSHYGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSe-kPVNLQMFIGTADDRylRPHAFYQVH 621  chicken
Feature 1          #                                        # ##             ## #                 
1OWR_M         84 RITGKTVTTTSYEKIVGNTKVLEIPLEPknNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESs--- 160  human
1P7H_M         86 RITGKTVTTTSYEKIVGNTKVLEIPLEPknNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESs--- 162  human
CAK04364      430 RITGKTVSTPSHEVLQSNTKVLEIPLLPesNMRAIIDCAGILKLRNSDIELRKGETDIGRKNTRVRMVFRVHINQPn--- 506  zebrafish
XP_417509     478 RITGKTVTTTSYEKIIGNTKVLEIPLEPknNMKATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESs--- 554  chicken
XP_700591     405 RITGKTVTTNSQDRMLNGTKILEVPMEPkeNMRAVIDCAGILKLRNADIELKKGETDVGRKNTRVRLVFRVHIPQPg--- 481  zebrafish
XP_690183     338 RVTGKMVGTASQESIQAGTKILDIPLNPenNMTALIDCAGILKLRNSDIELRKGETDVGRKNTRVRLVFRTHLPLSqpiv 417  zebrafish
NP_001129494  549 RITGKMVATASYEAVVSGTKVLEMTLLPenNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGg--- 625  human
NP_001135546  486 RITGKTVATASQEIVITNTKVLEIPLLPenNMTASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQTs--- 562  western clawe...
P97305        500 RITGKTVATASQEIIIASTKVLEIPLLPenNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPs--- 576  house mouse
XP_414078     622 RITGKTVATASQEIIIASTKVLEIPLLPenNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQTs--- 698  chicken
Feature 1                           # 
1OWR_M        161 --GRIVSLQTASNPIECSQR 178  human
1P7H_M        163 --GRIVSLQTASNPIECSQR 180  human
CAK04364      507 --GRTVSLQVASNPIECSQR 524  zebrafish
XP_417509     555 --GRIISLQAASNPIECSQR 572  chicken
XP_700591     482 --GQWLSLQVASQTIECSQR 499  zebrafish
XP_690183     418 ppGRVLALQVASLPIECSQR 437  zebrafish
NP_001129494  626 --GKVVSVQAASVPIECSQR 643  human
NP_001135546  563 --GKVLSLQAASVPIECSQR 580  western clawed frog
P97305        577 --GKVLSLQIASIPVECSQR 594  house mouse
XP_414078     699 --GKVLSLQTASIPVECSQR 716  chicken

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