3GP0


Conserved Protein Domain Family
STKc_p38beta

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cd07878: STKc_p38beta 
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Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase (also called MAPK11)
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38beta/MAPK11 is widely expressed in tissues and shows more similarity with p38alpha than with the other isoforms. Both are sensitive to pyridinylimidazoles and share some common substrates such as MAPK activated protein kinase 2 (MK2) and the transcription factors ATF2, c-Fos and, ELK-1. p38beta is involved in regulating the activation of the cyclooxygenase-2 promoter and the expression of TGFbeta-induced alpha-smooth muscle cell actin. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 143383
View PSSM: cd07878
Aligned: 4 rows
Threshold Bit Score: 765.748
Threshold Setting Gi: 226438344
Created: 24-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:3GP0_A; Human p38beta binds Nilotinib inhibitor; defined at 4A contacts.
    View structure with Cn3D
  • Comment:also based partly on the binding of MgAMP-PNP to p38gamma

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                              ##   # ##            # #                     #        # # 
3GP0_A         6 FYRQELNkTVWEVPQRLQGLRPVGSGAYGSVCSAYDArlRQKVAVKKLSRPFQslIHARRTYRELRLLKHLKHENVIGLL 85  human
NP_001087984   7 FYKQELNkTVWEVPERYQRLTPVGSGAFGSVSSAFDTktRQKVAVKKLSRPFQslVHARRTYRELRLLKHMKHENVIGLL 86  African clawed ...
NP_001002095   7 FYRQELNkTVWEVPERYQNLTPVGSGAYGSVCSAYDVrlRQKVAVKKLSRPFQslIHSRRTYRELRLLKHMKHENVIGLL 86  zebrafish
NP_001006227   7 FYRQELNkTVWEVPQRYQNLTPVGSGAYGSVCSAYDTktRQKVAVKKLSRPFQslIHARRTYRELRLLKHMKHENVIGLL 86  chicken
Feature 1                        # ####  #                                     # # ##           #
3GP0_A        86 DVFTPATSiedFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRIL 165 human
NP_001087984  87 DVFTPSTSgenFNEVYLVTNLMGADLNNIVKCQKLTDDHIQFLIYQLLRGLKYIHSAGIIHRDLKPGNLAVNEDCELRIL 166 African clawed ...
NP_001002095  87 DVFTPAASleeFNEVYLVTNLMGADLNNIVKFQRLSDEHVQFLIYQLLRGLKYIHSAGLIHRDLKPSNVAVNEDCELRIL 166 zebrafish
NP_001006227  87 DVFTPATSienFNEVYLVTNLMGADLNNIVKCQKLTDDHIQFLIYQLLRGLKYIHSAGIIHRDLKPSNLAVNEDCELRIL 166 chicken
Feature 1        # #                                                                             
3GP0_A       166 DFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 245 human
NP_001087984 167 DFGLARQADDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLKGKALFPGNDYIDQLKRIMEVAGTPNSEFL 246 African clawed ...
NP_001002095 167 DFGLARQTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMGELLKGKVLFPGNDYIDQLKRIMEVVGTPTPDVL 246 zebrafish
NP_001006227 167 DFGLARQTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLKGKALFPGDDYIDQLKRIMEVVGTPSSELL 246 chicken
Feature 1                                                                                        
3GP0_A       246 AKISSEHARTYIQSLPPMPQKDLSSIFRGaNPLAIDLLGRMLVLDSDQRVSAAEALAHAYFsQYHDPEDEPeaEPYDESV 325 human
NP_001087984 247 MKISSEHARRYIESLPYMPHQDLKEVFRGaNPLAIDLLEKMLILDSDKRISATEALAHPYFvQYHDPDDEPeaEPYDEST 326 African clawed ...
NP_001002095 247 KKISSEHAQKYIQSLPHMPQQDLGKIFRGaNPLAVDLLKKMLVLDCDGRISASEALCHPYFsQYHDPEDEPeaPPYDQTP 326 zebrafish
NP_001006227 247 KKISSEHARKYFESLPHMPQQDLKAVFRGaNPLAVDLLEKMLILDSDKRITASAALAHPYFvQYHDPDDEPeaELYDESI 326 chicken
Feature 1                               
3GP0_A       326 EAkeRTLEEWKELTYQEVLSFKP 348 human
NP_001087984 327 ENkeRTIDEWKEITYEEVISFKS 349 African clawed frog
NP_001002095 327 ESkdRTMEEWKELVFEEVSNFKD 349 zebrafish
NP_001006227 327 ENkeRTIEEWKELTYEEVMSFKP 349 chicken

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