3E7O


Conserved Protein Domain Family
STKc_JNK2

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cd07876: STKc_JNK2 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK2 is expressed in every cell and tissue type. It is specifically translocated to the mitochondria during dopaminergic cell death. Specific substrates include the microtubule-associated proteins DCX and Tau, as well as TIF-IA which is involved in ribosomal RNA synthesis regulation. Mice deficient in Jnk2 show protection against arthritis, type 1 diabetes, atherosclerosis, abdominal aortic aneurysm, cardiac cell death, TNF-induced liver damage, and tumor growth, indicating that JNK2 may play roles in the pathogenesis of these diseases. Initially it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 143381
View PSSM: cd07876
Aligned: 3 rows
Threshold Bit Score: 735.297
Threshold Setting Gi: 30315985
Created: 24-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                 ####### #            # #                            
3E7O_A      2 SHMDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHK 81  human
P79996      4 SKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHK 83  chicken
CAG01196    1 SEEEGQFYSVQVGDSTFTVLKRYQQLRAIGSGAQGIVCSALDTVLGIPVAVKKLCRPFQNQTHAKRAYRELVLLKCVNHK 80  spotted green puff...
Feature 1       #                     #######                                           #     
3E7O_A     82 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC 161 human
P79996     84 NIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC 163 chicken
CAG01196   81 NIIRLINVFTPQKSLEEFQDLYLVMELMDANLCQVIHMDLDHERMSYLLYQILCGIRHLHSAGIIHRDLKPSNIVVKSDC 160 spotted green puff...
Feature 1         #                                                                           
3E7O_A    162 TLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGT 241 human
P79996    164 TLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGT 243 chicken
CAG01196  161 TLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMKYKENVDIWSVGCIMGEMVKGSVIFQGTDHIDQWNKVIEVLGT 240 spotted green puff...
Feature 1                                                                                     
3E7O_A    242 PSAEFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITV 321 human
P79996    244 PSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESDRDKLKTSQARDLLSKMLVVDPDKRISVDEALRHPYITV 323 chicken
CAG01196  241 PSLEFMNRLMETVRNYVMNKPQYHGVSFTELFPDWAFPSDSEHDKLKTSQARDLLSKMLVIDPECRISVEEALNHPYIHV 320 spotted green puff...
Feature 1                                            
3E7O_A    322 WYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 360 human
P79996    324 WYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 362 chicken
CAG01196  321 WYDPAEADAPPPQISDKQLEEREHTIEQWKELIYEEVID 359 spotted green pufferfish

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