Conserved Protein Domain Family
STKc_CDC2L1

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cd07843: STKc_CDC2L1 
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L1, also called PITSLRE, exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products, CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110), the major isoform, associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis, centrosome maturation, sister chromatid cohesion, and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f), p21-activated kinase (PAK1), and Ran-binding protein (RanBPM). CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 173741
View PSSM: cd07843
Aligned: 29 rows
Threshold Bit Score: 482.109
Threshold Setting Gi: 85109223
Created: 31-Jul-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     ####    #            # #                  #              #         
P21127       432 CRSVE-EFQCLNRIEEGTYGVVYRAKDKKTdEIVALKRLKMEKEK--EGFPITSLREINTILKAq-HPNIVTVREIVVGs 507 human
CAA56732     368 CRNVK-NYKKLNKISEGTYGAVYRAQNKRTkKIVALKKLKNFSSMhnEGFAMTSLREINILLQLq-HDNILSIKEVVFGk 445 malaria parasit...
CAA18412      68 CNSID-DYEILEKIEEGSYGIVYRGLDKSTnTLVALKKIKFDPNG--IGFPITSLREIESLSSIr-HDNIVELEKVVVGk 143 fission yeast
EER16049      60 CRSVD-NYEKLNRIDEGTYGVVYRAREKTTgKICALKQVKLREQDdsSGFPLTALREVDTLLRLr-HENIITVSEVAVGa 137 Perkinsus marin...
AAD17245     218 CRRVE-IFKRLNKISEGTYGAVFRAMNRTTgEIVALKQIKYHNKLwsEGFPVTSLREISIMLELq-HPNVLDVQEVVVGt 295 Toxoplasma gondii
XP_001007724  80 CDSVD-NYQKLNKIHEGVYGVVYRAVDKLTgEIIAIKKTKIDRKKekEGFPITSIREFNILMALr-HENIVAVKRVVMGt 157 Tetrahymena the...
EAL23267     156 CRSVY-NYTRLNHIEEGTYGVVFRARCNDTgEIYALKKLKLDEEK--QGFPITSLREVMALMISggHENVVGIREIVVGd 232 Cryptococcus ne...
XP_001729355  45 CGSVS-SYEILNRIEEGSYGVVSRARHKQTgEIVALKQLKFEKEG--LGFPITSLREVQVLMEAr-HPHIVELKEMVVGd 120 Malassezia glob...
XP_002288085   1 CRSVYdSYERISHLDEGTYGVVWKAKDNSTgEIVALKQIKFDSEMtkEGFPISALREIGVLLSLs-HECIVTVREMVVGs 79  Thalassiosira p...
XP_953202     86 CRDVE-CFKCLNKISEGTYGTVYRALEIKTgKIVALKHIKYHDVQwkEGFPLTYLREISILLQLn-HPNILSVKEIVTNk 163 Theileria annul...
Feature 1                ####  # ##                                       # # ## #          #  # 
P21127       508 nmDKIYIVMNYVEHDLKSLMETMKq---pFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHaGILKVGDFGLA 584 human
CAA56732     446 hlNDIYLVMEYIEHELKMILDNKSp---sFTISELKCLLKQLLSGINYLHRNWVMHRDLKPTNLLYSNkGILKICDFGMA 522 malaria parasit...
CAA18412     144 dlKDVYLVMEFMEHDLKTLLDNMPe---dFLQSEVKTLMLQLLAATAFMHHHWYLHRDLKPSNLLMNNtGEIKLADFGLA 220 fission yeast
EER16049     138 rsTQIYMVMEYMEHELKDLLEHLTpd-egLRQAEVKSLVVQLLSGVAYMHERWIIHRDLKTSNLLFNNrGVLKICDFGLA 216 Perkinsus marin...
AAD17245     296 gqHQVFMVMEYIEHEVKTLLDEKPe----FSTAERKCLLYQLLEALAYMHANFVFHRDLKPSNLLYSNrGVLKVADFGMA 371 Toxoplasma gondii
XP_001007724 158 dlDSIYMIMEYMEHELKDVIENHHd---eFQEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNkGQLKICDFGLG 234 Tetrahymena the...
EAL23267     233 tlNQVFIVMPFIEHDLKTLLADMPh---pFLQSEVKTIMLQLLSAVAHCHANWILHRDLKTSNLLMNNrGQIKVADFGLA 309 Cryptococcus ne...
XP_001729355 121 tiNHVYLVMEFVEHDLKTLLTTMRt---pFLLSEIKTLMKQLLSAVALMHSRWIVHRDLKASNLLLSNrGQIKIADFGLA 197 Malassezia glob...
XP_002288085  80 thDKVFMVMECMEMDLQAAMKHGPgtsspFAQSEVKFMMHQLLSAMAHVHERWFLHRDVKTSNVLVHKsGRIALCDFGLA 159 Thalassiosira p...
XP_953202    164 kqDQFYMVMEYVEHELKTLLEENRp---nFTLSERKCLLKQLLDGINYLHQNWVMHRDLKTTNILYNNsGLVKICDFGMA 240 Theileria annul...
Feature 1                    # #### #                                       ##                   
P21127       585 REYGSPl--KAYTPVVVTLWYRAPELLLGAKE--YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEK 660 human
CAA56732     523 RKFGHVt-nHNFTKNVVTLWYRAPELLLGEQC--YTNKIDIWSAGCIFAEMILKKPLFVGENEIDQLFKILCLLGLPDKE 599 malaria parasit...
CAA18412     221 RPVSEPk--SSLTRLVVTLWYRAPELLLGAPS--YGKEIDMWSIGCIFAEMITRTPLFSGKSELDQLYKIFNLLGYPTRE 296 fission yeast
EER16049     217 RQYSEPi--DTMTRKVVTLWYRAPELLLGPADykYTTAIDMWSCGCIVGEIIRRDPLFAEASEVDVLEKILDLVGTPNVN 294 Perkinsus marin...
AAD17245     372 RKFGFPlhnRVFTKNVVTLWYRPPEILLGEGT--YDAACDVWAVGAIFGEFLRKKPLFAGHGELDTLNKIFKLCGTPTDS 449 Toxoplasma gondii
XP_001007724 235 RRWQGN---KPYTLNVVTMWYRAPEVLLGQDK--YTTALDMWSVGCIFGELITKDQLFKGKNETNQIECIFNAMGGPTER 309 Tetrahymena the...
EAL23267     310 RKFGDPl--GEMTQLVVTLWYRSPELLLGGKE--YTTAVDIWSIGCIFAELMQGEPLFPGRGEIDQINRIFQLLGRPNDE 385 Cryptococcus ne...
XP_001729355 198 RLFGDPl--TDMTSLVVTLWYRAPELLLGKKR--YDTAIDMWSVGCIFAELLMKEPLFPGKNETDQLSRILRLLGSPTET 273 Malassezia glob...
XP_002288085 160 RKYEVPa--KNMTQMVVTLWYRAPEVLFGESK--YGAEIDLWSIGCIFGELLTKDAMLKGTGELDQIQKIFKLVGTPNED 235 Thalassiosira p...
XP_953202    241 RKFGVPi--RKYTHNVVTHWYRAPELFLGEPY--YTEKTDVWSIGCIFAELILSRPLFMGTNDADTLDKIFRLCGSPNEE 316 Theileria annul...
Feature 1                                                                                        
P21127       661 I-WPGYsELPAVKk------MTFSEHPYNNL--RKRFGAl-----------lSDQGFDLMNKFLTYFPGRRISAEDGLKH 720 human
CAA56732     600 S-YPEFyEYSFISknkelfkKKKIKMNVNNI--RSHFPNianqf---sglylSDNGLDLLQKMLHYNPQCRISAQEALNH 673 malaria parasit...
CAA18412     297 E-WPQYfLLPYANk-----iKHPTVPTHSKI--RTSIPNl------------TGNAYDLLNRLLSLNPAKRISAKEALEH 356 fission yeast
EER16049     295 RkWPEFrSYVTAKg-----lKIRTRQPNWRSa-AIGFPQagivss--vscplTHVGLDLMQGLLDLNPVTRLSAKAALNH 366 Perkinsus marin...
AAD17245     450 S-WPEFhSLPHIKn-----kKFFNSPPQCQPswREVFPPpskhlamgssgvlTDLGLDLLQKLLELNPAKRITAAEALQH 523 Toxoplasma gondii
XP_001007724 310 S-WPGWtEFKHSKl-----fKDRNYPSECTL--NEKIGNr-----------iSQTGYKLLCQMLTLNPKERITATKALQD 370 Tetrahymena the...
EAL23267     386 S-WPGYsTLPLVQk------INPIGPMFSTL--RQKFKHl------------TYEGHNLLSSLLCYDPERRITAEEALKH 444 Cryptococcus ne...
XP_001729355 274 T-WPEFaSLLKSR-------FKHTTHVRSQL--RHHFRLf------------SDATVDLLQSFLCYDSSKRISAHDALQH 331 Malassezia glob...
XP_002288085 236 N-WPEFsSLPSAGt------FKWKNKDGSEL--GRRFQVnsfsat--gqsylDTSGFDLLGKLLALNPRQRISAEDALKH 304 Thalassiosira p...
XP_953202    317 N-WPGFsKLPGIVs------NKFQIHKYNPSf-ENVFKVgimggmvhgstcmTELGLDLLKKMLNIDPNQRISAKDALNH 388 Theileria annul...
Feature 1           
P21127       721 EYF 723 human
CAA56732     674 PYF 676 malaria parasite P. falciparum
CAA18412     357 PYF 359 fission yeast
EER16049     367 PWL 369 Perkinsus marinus ATCC 50983
AAD17245     524 EYF 526 Toxoplasma gondii
XP_001007724 371 PWF 373 Tetrahymena thermophila
EAL23267     445 PYF 447 Cryptococcus neoformans var. neoformans B-3501A
XP_001729355 332 AYF 334 Malassezia globosa CBS 7966
XP_002288085 305 PYF 307 Thalassiosira pseudonana CCMP1335
XP_953202    389 PYI 391 Theileria annulata strain Ankara

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