1UNL,1H4L,1UNG


Conserved Protein Domain Family
STKc_CDK5

?
cd07839: STKc_CDK5 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK5 is unusual in that it is regulated by non-cyclin proteins, p35 and p39. It is highly expressed in the nervous system and is critical in normal neural development and function. It plays a role in neuronal migration and differentiation, and is also important in synaptic plasticity and learning. CDK5 also participates in protecting against cell death and promoting angiogenesis. Impaired CDK5 activity is implicated in Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease and acute neuronal injury. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
?
PSSM-Id: 143344
View PSSM: cd07839
Aligned: 14 rows
Threshold Bit Score: 536.246
Threshold Setting Gi: 167522771
Created: 18-Jul-2006
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1               ####    #            # #                              #               ###
1UNL_B         3 KYEKLEKIGEGTYGTVFKAKNRethEIVALKRVRLDDDDEGVPSSALREICLLKELkHKNIVRLHDVLHsdKKLTLVFEF 82  human
1H4L_B         3 KYEKLEKIGEGTYGTVFKAKNRethEIVALKRVRLDDDDEGVPSSALREICLLKELkHKNIVRLHDVLHsdKKLTLVFEF 82  human
1UNG_A         3 KYEKLEKIGEGTYGTVFKAKNRethEIVALKRVRLDDDDEGVPSSALREICLLKELkHKNIVRLHDVLHsdKKLTLVFEF 82  human
P48609         3 KYDKMEKIGEGTYGTVFKGRNRdtmEIVALKRVRLDEDDEGVPSSALREICLLKELkHKNIVRLIDVLHsdKKLTLVFEH 82  fruit fly
P51166         3 KYEKLEKIGEGTYGTVFKAKNRdthEIVALKRVRLDDDDEGVPSSALREICLLKELkHKNIVRLHDVLHsdKKLTLVFEF 82  African clawed ...
NP_499783      3 NYDKMEKIGEGTYGTVFKARNKnsgEIVALKRVRLDDDDEGVPSSALREICILRELkHRNVVRLYDVVHseNKLTLVFEY 82  nematode
AAW25037       8 KYEKLEKIGEGTYGKVYKARNRethEIVALKRVRLENDDEGIPSSAFREICLLKELkHKNIVRLFDVLLsdSRLTIVFEY 87  Schistosoma jap...
XP_001641483   3 KYDKLEKIGEGTYGTVFKGKNKetrEILALKRVRLDDDDEGVPSSALREICLLKELkHNNIVRLYDVLHseKKLTLVFEF 82  starlet sea ane...
XP_002129982   3 KYEKIEKIGEGTYGTVFKAKNResgEVVALKRVQLDDDDEGVPSSALREICILKELkHKNVVRLHDVLHseRKMTLVFEY 82  Ciona intestinalis
NP_001129258   3 KYEKLEKIGEGTYGTVFKAKNRethEIVALKRVRLDDDDEGVPSSALREICLLKELkHKNIVRLHDVLHsdKKLTLVFEF 82  chicken
Feature 1        #  #  #                                        ## #          #                  
1UNL_B        83 CDQDLKKYFDsCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLANFGLARAFGIPVRCYSAEV 162 human
1H4L_B        83 CDQDLKKYFDsCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV 162 human
1UNG_A        83 CDQDLKKYFDsCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLANFGLARAFGIPVRCYSAEV 162 human
P48609        83 CDQDLKKYFDsLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEV 162 fruit fly
P51166        83 CDQDLKKYFDsCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV 162 African clawed ...
NP_499783     83 CDQDLKKFFDsLNGYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEV 162 nematode
AAW25037      88 CDQDLKKYFDnCNGEIDQNTVKLFMFQLLRGLQFCHSHNVLHRDLKPQNLLINDNGELKLADFGLARAYGIPVRQYSAEV 167 Schistosoma jap...
XP_001641483  83 CDQDLKKYFDsCQGEVDASVVKSFMFQLLRGLAFCHSHNVLHRDLKPQNLLINKDGELKLADFGLARAFGIPVRCFSAEV 162 starlet sea ane...
XP_002129982  83 CEQDLKKYFDsCGGEIDRPTVQSFMYQLLKGLAFCHQQNILHRDLKPQNLLINKNGELKLADFGLARSFGIPVRCYSAEV 162 Ciona intestinalis
NP_001129258  83 CDQDLKKYFDsCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEV 162 chicken
Feature 1                                                                                        
1UNL_B       163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAgRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY-KPYPM 241 human
1H4L_B       163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAaRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY-KPYPM 241 human
1UNG_A       163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAgRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDY-KPYPM 241 human
P48609       163 VTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAgRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDY-VALPS 241 fruit fly
P51166       163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAgRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDY-KPYPM 241 African clawed ...
NP_499783    163 VTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAgRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLPDY-KPYPI 241 nematode
AAW25037     168 VTLWYRPPDVLLGAKLYTTSIDMWSAGCIFAEMSNAgRPLFPGYDVEDQLQRIFKLLGTPTESTWPSVVELPDYePFTVM 247 Schistosoma jap...
XP_001641483 163 VTLWYRPPDVLMGAKLYSTSIDMWSAGCIFAEMANGgRPLFPGNDVDDQLRRIFKILGTPTEESWPNVSKLPDY-KEFPP 241 starlet sea ane...
XP_002129982 163 VTLWYRPPDVLFGAKLYSTTIDTWSAGCIFAEISNAgVPLFPGNDVEDQLKRIFKVLGTPTEQSWPGVSKLPDF-KIFPL 241 Ciona intestinalis
NP_001129258 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAgRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMAKLPDY-KPYPM 241 chicken
Feature 1                                                     
1UNL_B       242 YPATTSlVNVVPKlnATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 human
1H4L_B       242 YPATTSlVNVVPKlnATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 human
1UNG_A       242 YPATTSlVNVVPKlnATGRDLLQNLLKCNPVQRISAEEALQHPYF 286 human
P48609       242 FPAITSwSQLVPRlnSKGRDLLQKLLICRPNQRISAEAAMQHPYF 286 fruit fly
P51166       242 YPATMSlVNVVPKlnATGRDLLQNLLKCNPVQRICADEALQHPYF 286 African clawed frog
NP_499783    242 YHPTLTwSQIVPNlnSRGRDLLQKLLVCNPAGRIDADAALRHAYF 286 nematode
AAW25037     248 YPRIMNwHHVVPKmsFRGRDLLQQLVACNPVDRISADQALKHSYF 292 Schistosoma japonicum
XP_001641483 242 QGPSVSlGMVVPKlsSTGRDLLQKLLVSNPAHRISAEDAMKHAYF 286 starlet sea anemone
XP_002129982 242 YPSNAHwAAITPRlsSSGHDLLKCLIVANPSERLTASNALKHRYF 286 Ciona intestinalis
NP_001129258 242 YPATTSlVNVVPKlnATGRDLLQNLLKVHPVQRISAEEALQHPYF 286 chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap