2PK9,2PMI


Conserved Protein Domain Family
STKc_Pho85

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cd07836: STKc_Pho85 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Pho85 is a multifunctional CDK in yeast. It is regulated by 10 different cyclins (Pcls) and plays a role in G1 progression, cell polarity, phosphate and glycogen metabolism, gene expression, and in signaling changes in the environment. It is not essential for yeast viability and is the functional homolog of mammalian CDK5, which plays a role in central nervous system development. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The Pho85 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 143341
View PSSM: cd07836
Aligned: 8 rows
Threshold Bit Score: 560.176
Threshold Setting Gi: 19075421
Created: 24-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ####    #            # #               #             #               ####
2PK9_A         6 QFKQLEKLGNGTYATVYKGLNKttgVYVALKEVKLDSEEGTPSTAIREISLMKELkHENIVRLYDVIHTEnKLTLVFEFM 85  baker's yeast
2PMI_A         6 QFKQLEKLGNGTYATVYKGLNKttgVYVALKEVKLDSEEGTPSTAIREISLMKELkHENIVRLYDVIHTEnKLTLVFEFM 85  baker's yeast
AAD39491       9 SFQQLEKLGEGTYATVFKGRNRhtgEFVALKEIHLDSEEGTPSTAIREISLMKELkHENIVALHDVIHTEsKLMLVFEYM 88  Sporothrix sche...
NP_587921      2 NYQRLEKLGEGTYAHVYKGQNRvtgEIVALKVIRIDADEGTPSTAIREISLMKELrHPNIMSLSDVLQTEnKLMLVFEYM 81  fission yeast
ABM67664       2 NYVQLEKLGEGTYATVYKGRSRlnnEIVALKEIHLDAEEGTPSTAIREISLMKELrHTNIVRLYDVIHTEsKLMLVFEYM 81  Ustilago maydis
O74456         2 NYQRLEKLGEGTYAHVYKGQNRvtgEIVALKVIRIDADEGTPSTAIREISLMKELrHPNIMSLSDVLQTEnKLMLVFEYM 81  Schizosaccharom...
AAW44915       2 NYVQLEKLGEGTYATVYKGRSRttsEIVALKEIHLDAEEGTPSTAIREISLMKELkHVNIVRLHDVVHTEsKLVLIFEYC 81  Cryptococcus ne...
XP_001388969   9 SFKKLEKLGQGTYATVYKGRNRetnELVALKEINLDAEEGAPSTAIREVSLLRRLtHENILTLHDVINVEdKLVLVFEYM 88  Aspergillus nig...
Feature 1          # ##                                         # # ## #          #  #           
2PK9_A        86 DNDLKKYMDSRtvgntprGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINkrGQLKLGDFGLARAFGIPVNTF 165 baker's yeast
2PMI_A        86 DNDLKKYMDSRtvgntprGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINkrGQLKLGDFGLARAFGIPVNTF 165 baker's yeast
AAD39491      89 DGDLKKYMDTNge---rgALKPMLIKSFMYQLLKGIDFCHQNRVLHRDLKPQNLLINgkGQLKLGDFGLARAFGIPVNTF 165 Sporothrix sche...
NP_587921     82 EKDLKKYMDTYgn---qgALPPSQVKNFTQQLLKGISFCHENRVLHRDLKPQNLLINsrGELKLADFGLARSIGIPVNTF 158 fission yeast
ABM67664      82 EQDLKKYMEIHgh---rcALDPVTTRSFMFQLLKGTAFCHENRVLHRDLKPQNLLINkrGELKLADFGLARAFGIPVNTF 158 Ustilago maydis
O74456        82 EKDLKKYMDTYgn---qgALPPSQVKNFTQQLLKGISFCHENRVLHRDLKPQNLLINsrGELKLADFGLARSIGIPVNTF 158 Schizosaccharom...
AAW44915      82 EQDLKRYMDIHgd---rgALDLNTVKSFTHQLLQGIAFCHDHRVLHRDLKPQNLLINkrGELKIGDFGLARAFGVPVNTF 158 Cryptococcus ne...
XP_001388969  89 DKDLKRYIDTHg-----gPLDAATAKSFVYQLLRGVSFCHENGILHRDLKPENLLLNqdGRLKLADFGLGRAFGIPISKF 163 Aspergillus nig...
Feature 1        # #### #                                     ##                                 
2PK9_A       166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTnDEEQLKLIFDIMGTPNESLWPSVt-KLPKYN- 243 baker's yeast
2PMI_A       166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTnDEEQLKLIFDIMGTPNESLWPSVt-KLPKYN- 243 baker's yeast
AAD39491     166 SNEVVTLWYRAPDVLLGSRTYNTSIDIWSVGCIMAEMYTGRPLFPGTtNEDQMLRIFRIMGTPTEHNWPGIs-QFPEYK- 243 Sporothrix sche...
NP_587921    159 SNEVVTLWYRAPDVLLGSRVYSTSIDIWSVGCIMAEMATGRPLFAGSnNEDQLLKIFRLLGTPTEQSWPGIs-LLPEYK- 236 fission yeast
ABM67664     159 SNEVVTLWYRAPDVLLGSRTYSTSIDVWSAGCIMAEMISGLPLFRGRdNNDQLNQILRILGTPDDNTMKRLvnDSPEIQm 238 Ustilago maydis
O74456       159 SNEVVTLWYRAPDVLLGSRVYSTSIDIWSVGCIMAEMATGRPLFAGSnNEDQLLKIFRLLGTPTEQSWPGIs-LLPEYK- 236 Schizosaccharom...
AAW44915     159 SNEVVTLWYRAPDVLLGSRTYSTSIDIWSVGCIFAEMITGYPLFRGRdNADQLVQIMKIVGTPSDATIAQIklNSPEIQ- 237 Cryptococcus ne...
XP_001388969 164 SSDVVTLWYRPPDVLLGSRTYTTSIDIWSVGCIMAEIYTGSALFTGTtNADQLLKIFNIMGTPTELTWPGVs-QLPEYR- 241 Aspergillus nig...
Feature 1                                                               
2PK9_A       244 PNIQQRPPRDLr-QVLQPhtkepldGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 baker's yeast
2PMI_A       244 PNIQQRPPRDLr-QVLQPhtkepldGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 baker's yeast
AAD39491     244 ATAPRYATQDL--RQILPqi----dATGIDLLQRLLQLRPELRISAHDALQHPWF 292 Sporothrix schenckii
NP_587921    237 PTFPIYKAQDL--AYLFPtf----dPLGLDLLRRMLRLQPELRTTGQDALQHAWF 285 fission yeast
ABM67664     239 RAFPRVPRVPF--QNMFPka----hPLAIDLLDKLLKFDPTQRISADEALRHPYF 287 Ustilago maydis
O74456       237 PTFPIYKAQDL--AYLFPtf----dPLGLDLLRRMLRLQPELRTTGQDALQHAWF 285 Schizosaccharomyces pombe
AAW44915     238 IKSPLAKHAKQpfQAIIPra----pRDAISLLEHLLQFEPTRRYDAHQAMAHQYF 288 Cryptococcus neoformans var. neoformans ...
XP_001388969 242 NDFPPCSPQSL--QQLIPsl----dPVGIDLLGRMLQLCPEARISATDALNHPWF 290 Aspergillus niger CBS 513.88

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