1XUV


Conserved Protein Domain Family
SRPBCC_CalC_Aha1-like_9

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cd07826: SRPBCC_CalC_Aha1-like_9 
Click on image for an interactive view with Cn3D
Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins
SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.
Statistics
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PSSM-Id: 176868
View PSSM: cd07826
Aligned: 31 rows
Threshold Bit Score: 160.493
Threshold Setting Gi: 84685519
Created: 24-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 43 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #        ### ##    #              #         # # # #         # ## #  #     #
1XUV_A        23 EIIITREFDAPRELVFKAFTDPDLYTQWIGprg-ftTALKIFEPKN--GGSWQYIQkdpe-gneyAFHGVNHDVTEpERI 98  Methanosarcina ...
YP_002882866  16 ELEVVRRFDAPRDLVFAALTQPALLRRWHGadg-wdLVVCDVDLRV--GGAWRFVArgpagepdmGYGGEFVEVEPpSRL 92  Beutenbergia ca...
YP_001536964  15 DIVLTRVFNAPRHLVFDTLTQPDLLKRWFGarg-whLVECEVDLRV--GGSWRFVSmgpg-nrrmGQGGVYHEVEApGRL 90  Salinispora are...
YP_823565     24 EIALKRIFKAPRELVYRAFSDPEILKRWFGpr---gWSLVTCHINSrvGGGFRFVLrapd-grelGMHGTYLELSPpERS 99  Solibacter usit...
YP_509848     14 AVRITRSFPAPRATIWRAFTDKAVLVHWLAgp--pgWEMEACDITLqpGGGYRWLWrhpdtgerfGFKGTYRVVEPgRRV 91  Jannaschia sp. ...
YP_002762980  18 EVRVTRDFRAPRTLVWQAHSDPALFQRWIGgypgwtMPVCEMDVRP--GGKYRWRWrsed-gnefGFYGEFREVDApGKM 94  Gemmatimonas au...
ZP_01013417   14 QLVVTRDFDAPTALVWRAHMEPDLLMKWQSgn--daFNVVECEIDAteGGTYRIVHssad--ytfTITGTFLELDEpNRI 89  Rhodobacterales...
YP_001840229  17 EVVFTRYFAAPRELVFECHTKPELMKRWLIgp--egMVLETCEQDLrvGGKYLYLYadkn-gnksGVYGTFREVVVpETL 93  Leptospira bifl...
Q6MH97        14 NIVVTRTFKAPKEKIFDAYTKPEHLKRWLLgp--qgWTLPVCTLDPkpGGEYHYLWrhed-gremGMHGVVKEIHRpDHL 90  Bdellovibrio ba...
Q98C00        41 EVQITRIFDASRPMVFDCWTIPELLKGWLHgp--dgWRLAICEIDLrvGGATRYVWqhrd-grsmGMSGAYREIVRpARI 117 Mesorhizobium loti
Feature 1         ##                     ## # #            # # # #        ######### ###  #      
1XUV_A        99 ISTFEFEglpe--------kghVILDTARFEALp--gDRTKLTSHSVFQTIEdrdgXLQSGXEEGINDSYERLDELLEK 167 Methanosarcina m...
YP_002882866  93 VQTERFDda------------wYTGIAHVTTDLaesdGVTTLRMRIRYASREvrdaVVASPMSRGMTEGYDRLARLLAT 159 Beutenbergia cav...
YP_001536964  91 AYTESYDdqw---------apgESLVTTVLTEHa---GRTTLTSTLRYASPEvrdlVLAAPMERGVGEGYDRLDDVLTS 157 Salinispora aren...
YP_823565    100 VHTEGFDgl-----------pgESLVTSTFTERn---GETTLLATIRYTSKEirdaVIRSGMEHGAAESYDKLSELLVA 164 Solibacter usita...
YP_509848     92 IDKQRFDqdgqa-----lpahaRTLNTVVFEDEg---QGCRVTTIIRYPDQAtrdmVVSEGLGEGMELSYQRLERLLLR 162 Jannaschia sp. CCS1
YP_002762980  95 VQAEFYDpgtfgg----ampttPTITQTTFTEQs---GVTTLVVLITYGSKEerdaAISTGMTDGMETSYGRLDTLVAE 166 Gemmatimonas aur...
ZP_01013417   90 LQEEVMYlpd---------ptpPNLVETLFKAKg---QATHMVVTMTLPDAQtrreMMETGMLDGMEISYKNLDALELA 156 Rhodobacterales ...
YP_001840229  94 ANTENYIfdlsafdpnapedpnATFESRTFTSEg---DKTLMTHVCRYASPEvckmMVESGAADGMAECYLELDRLLDK 169 Leptospira bifle...
Q6MH97        91 LTTELFDepw---------ypgEGLNDLSLTEDg---KTTLHTLVMRYESKAardmVLQSGMQRGLSESYDRLEDLLRI 157 Bdellovibrio bac...
Q98C00       118 VATELFDedw---------tggETVGTVVFTEQa---GKTLLTQTVLYASQAardgALGTGMTRGMGESYAQLDAYLIS 184 Mesorhizobium loti

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