Conserved Protein Domain Family
SRPBCC_7

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cd07825: SRPBCC_7 
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins
Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
Statistics
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PSSM-Id: 176867
View PSSM: cd07825
Aligned: 19 rows
Threshold Bit Score: 179.853
Threshold Setting Gi: 158315311
Created: 23-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #        ### ##          #          # # # #                   # #     # #  
YP_288386      5 KVSRSITVNAPAERIFAILTNPRRHAEIDGSAMVSGclhGPETLTAGSEFRMDMsml---gvpYRMTNRVVEYEkNRRIA 81  Thermobifida fu...
ZP_00993421    6 QITVSRTIDAPAQAIFDVLSNPERHPALDGSGFVRSvaqADRIQKVGEVFTMNMagdh-mggdYQTDNHVTGYDeNSLLA 84  Janibacter sp. ...
YP_885261    196 IVSASREIAAPSDVIFELIADPAQQPRWDGNENLLRmasGGRVRGVGEVFTMEIkq------gGFRDNHVIEFEeGRRIA 269 Mycobacterium s...
YP_908232     15 VVSATREIAAGAAQIFELIADPSRQPDWDGNDNLAHcaaGQRVHRVGDVFRMTLtl------gSVRENHIVEFTeARLIA 88  Mycobacterium u...
YP_887721      5 IMTAERIVDAPAATVFGVLADPTAHHAIDGTGWVREsldSAKLTTVGQIFRMAMyhrnfggmhYTVANRVEVFDpPIAIA 84  Mycobacterium s...
NP_738088      6 KYTVSRTINASIDQVWDVISNPELHKEFDSSGRVRSdekSNRIQATGEVFTMNMegp---ngaYKTDNHVVGYNeHKLLA 82  Corynebacterium...
YP_001069851   5 VMTAKTTVDAAAEAVFAVLADPSTHAAIDGTGWVREsldGTPLTAEGQLFRIAMyhdrlpdghYEMENKVVAFDpPRVIA 84  Mycobacterium s...
YP_712719    123 HTTVSRVLDAPADRIFAVLRDPRRHPELDATGFLRRaetLDPIGAVGDTFVMAMhnde--qgdYRIENHVVTFTeNRVIG 200 Frankia alni AC...
YP_001131429  15 NMIVTATVDAPVSAVFSVLADPAQHAAIDGTGWVREgldGEFLSRAGQLFRMAMyhdnvpnghYEMVNKVIAFErDREIG 94  Mycobacterium g...
YP_889003      6 RYVVTRRIHAAPQDVFRVLADPARHKDTEPGDWVRDaidPQPITDTGQIFAINMfleq-agghYVMHNRVTEYDeDRTIA 84  Mycobacterium s...
Feature 1                            ## # #      # # # #              ##### ### ###  #     
YP_288386     82 WRHi----------gPHRWRWQLEPVDdHTTRVTETFDYSpagpfailyqlAGYPARNARAIEQTLLRLKALAE 145 Thermobifida fusca YX
ZP_00993421   85 WQTtpag----tepfGWEWVWRLEQQGpDQTLVTHTYDWSkvtd----keiLQKVKFPLVSQSQLDDTLAKLAE 150 Janibacter sp. HTCC2649
YP_885261    270 WRPavag----eqplGHLWRWELQPAGeGRTLVTHTYDWTqltd---ekrfPKASATTADKLQESVDRLAAIVE 336 Mycobacterium smegmat...
YP_908232     89 WRPselg----ktppGHLWRWELTPISgTRTLVTHTYDWTelsd---parfPRARATTTVQLRASLDRLAGHAE 155 Mycobacterium ulceran...
YP_887721     85 WLPgedtddgtlkfgGWSWRYDLESLApARTRITLTYDWSavpda--irqhIGFPPFDPQHLDNSLKHLAGLAE 156 Mycobacterium smegmat...
NP_738088     83 WATapag----qdplGWQWVWELNSTDsDTTEVSLTYDWSkvsde--mqkkFNLPLLDEKELEDSLANLAAAVE 150 Corynebacterium effic...
YP_001069851  85 WEPgqrvng-elefgGWTWRYDLVSLGpARTEVTLTYDWSavsah--lrehITFPPFGQDHLDNSLRNLSSLAR 155 Mycobacterium sp. JLS
YP_712719    201 WAPgrps----qradGHRFTWTLTPTDdGRTEVTHTYDWAavth---pakvPRLPLVSAAQLEASVGQLATMVA 267 Frankia alni ACN14a
YP_001131429  95 WEPgqagpdgvvgygGWTWHYTLEPIGpAQTRVTLTYDWSgvpae--lrehIEFPPFPDTHLKNSLDNLATLVV 166 Mycobacterium gilvum ...
YP_889003     85 WEPgllddagnhspgGWFWRYDLQPDG-DATAVTLTYDWTdtpqs-fadqiGGMPPFPEQFIAESLATLDRAVR 156 Mycobacterium smegmat...

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