Conserved Protein Domain Family
SRPBCC_6

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cd07824: SRPBCC_6 
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins
Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
Statistics
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PSSM-Id: 176866
View PSSM: cd07824
Aligned: 23 rows
Threshold Bit Score: 149.391
Threshold Setting Gi: 226308800
Created: 13-Jul-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # # #         ### ##           #            # # # #                  # #      
ZP_01128370    6 FHLHSHWRVQA-GIDEVFEVISEPLHFVRWWPAVYLEVEEie--pgDGDGVGRtlnlhtRGLLPYt-LHWRATATEVn-K 80  Nitrococcus mob...
NP_625814      6 YRFRSRWPLPA-PAPDVYRALERIEDYPRWWPQVREVTRLd-----DTSGLLRf-----RSLLPYd-LTATVREQRRdpT 73  Streptomyces co...
NP_102783      6 FRFDESWDIPEgTPQQVWDVLSDAELLPLWWGEVYKEVVPld--gkGKASVGSrararaRGALPYe-LNFIIEAAELe-P 81  Mesorhizobium l...
YP_001214709   4 YFFKTVWHFDA-PPEKVWELIKDARSMPEWWPGVKRFEILsk---eRELQPGCliqasvKGLTGD--LNFELEVSKAv-P 76  Dehalococcoides...
YP_924712      5 FAFGGRWFVPA-SPSAVHDVLVDLEHYPDWWPQVVAVASLg----pDDARVLC------RSVLPYt-LDLVLHAADR--S 70  Nocardioides sp...
ZP_01463001    6 YRFIEHWDIPGfTPDEVWQVVIDATKLPEWWRGVYQEVEVlspeeiSAEGGWLra--raRGLLPYq-LRFMLEPVVLd-P 81  Stigmatella aur...
ZP_04700971    6 YRFHSRWELPA-APDAVYRVLEDVPGYPYWWREVREVRRTg-----ETEGVLRf-----RSLLPYd-LRVTARVSRQdpD 73  Streptomyces al...
YP_002881734   7 YALTSRWCVPA-PRAACWSQLADPGSWPEWWPHLRSRVLRd----gDEAGVGTrgvlvyRSPLGYr-LRIGLEVLAAd-P 79  Beutenbergia ca...
YP_001623937   4 YSLHTVWRLPA-SSERCWHELVVLRSWQHWWPAFQLSSPSs----sHDPSIGEelmltvRSPLGYk-LRVGLKITDIt-H 76  Renibacterium s...
YP_002768760  15 FDFHSVWTLPA-SADRVYDVLADAERYSQWWPQIRRVRAT------DEHSGSMa----iRSAVPLtlLVFGRREVVDp-V 82  Rhodococcus ery...
Feature 1           # #         ## # #           # # # #             #####    ###  ###  #    
ZP_01128370   81 PMRLVVEARGDLEGTGEWNLHQ----DGEWTEVDYDWKVFANKpWMRYLAPLLRPVFAANHHWAMNKGRQGLAQEL 152 Nitrococcus mobilis...
NP_625814     74 EGVLEVAMSGDMEGWARWTVAP----RGSASLVRYDQEVVVRKpLLRRLAVPGRPLFRANHRLMMRAGRRGLAAHL 145 Streptomyces coelic...
NP_102783     82 GRLVVVKTFGDFDGLWRAELSP----SGSGTHVQLTWQVTVERpILKFLAPLLRPAFAWNHRWTTPRGEAGLRRYL 153 Mesorhizobium loti ...
YP_001214709  77 CHEIVMLSRGDLMGQGVWTLTP----DNGKTISTYIWEVTTTGkLMNAIGSVCKPVFIWNHNRVMTAGFKALKKRL 148 Dehalococcoides sp....
YP_924712     71 PSRLEVGVSGDLIGSVCFKLTPa--dDGRGTHLDLDQEVTVPG-LLGLAAYAAGPVLRWNHHRMMAGCVAGLSARL 143 Nocardioides sp. JS614
ZP_01463001   82 NGIIEVRAYGDFKGVWRATFSA----TEDGTRIDIEWEVTVNKpIIRFTGWLLKPLFAWNHRWTMPRGEAGLLAYL 153 Stigmatella auranti...
ZP_04700971   74 ARLIEAALGGDLVGTLVWRVGA----VPGGARVDFEQDVRVTSrMMRLLAVPGRPFFRANHALMMRSGRAGLARLL 145 Streptomyces albus ...
YP_002881734  80 PERVEFAVVGDLTGRATAQLDEverdGAAWTSITTRWPVRTTRgWMNAAAPVLAPAFNWAHARVMSAGERGLVRRL 155 Beutenbergia cavern...
YP_001623937  77 LSRLQVSGSGDLNGVGGTNFADegssEQPKTVISIGWTVRTTKrWMNLLAPVAAPAFSWAHRKVMADGERRFQNYL 152 Renibacterium salmo...
YP_002768760  83 ARRLQVRLSGAMIGWSSWVVRP----AESGCVADFRQQVAVSG-ALGLASKIAKPVFEWNHEAMMRGGHRGLSAYL 153 Rhodococcus erythro...

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