Conserved Protein Domain Family
SRPBCC_5

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cd07823: SRPBCC_5 
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins
Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
Statistics
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PSSM-Id: 176865
View PSSM: cd07823
Aligned: 33 rows
Threshold Bit Score: 116.572
Threshold Setting Gi: 21222067
Created: 12-Jul-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #        ### ##           #            # # # #              # #         # # 
YP_644627       3 IQNQIEVAAPPDELFDILADVERVAPLLPGATLEGKEd----dDTYAGTVKVKVGPITTSYRGTIRFQELdhDARRAVMR 78   Rubrobacter x...
NP_627846      17 MEHEVFVPVPAERLRDVLADPVRVARAVPGLQQDAGA------EPVAGRLKVRIGSHSITYRGSLRLSARgdGTYAVEGD 90   Streptomyces ...
ZP_03543693     3 IEKTLTVSAPPQQVWDLLLNPQIMAGAVPGMKSIEVIs----pTEYVAEMHQKISFISARFKLKTRLVEQk-APEYMRVE 77   Comamonas tes...
YP_873394       3 IEQSLEVPVPIDRVWSFFDDVPRVASCMPGATLTEVLd----dRTFDGTVVVKVGPISVHYQGRLTIEDKdkTSYSVRLQ 78   Acidothermus ...
YP_558873       5 LEKVFPLAATADSAWQLMQDIEAVAGCMPGAKITERId----dTHYKGTITVRLGPATMSFKGDIEVLDLdpAARSLHLT 80   Burkholderia ...
ZP_02188060     4 LSEQTTIPSPPETVWPLLSDPALIASCIPGAELAPDQg----dGLWRGSIRVKFGPTVATFRGEVALTYDh-ANRTCSIE 78   alpha proteob...
YP_002780918    4 IDEEIAVPAPPGRVWAVISDPTDVVSCINGAELGQFHd----dGSFDGTLVVKFSAIRVRFGARMSLELDe-PAWEGRLS 78   Rhodococcus o...
YP_742401     842 LERDYGLDVPADPAWTLMQDIREVAACMPGASIVEQTg----eRTYLGEMRLKVGPITSAFKGDIEVLDLdpTRQTLRLR 917  Alkalilimnico...
CAJ49185      225 IEGGFTVNYPADQVWKFMADLPAVASCLPGAQLTDHEkqanggERVKGHVGIKFGPMSAAFNGSAKLQRDe-ANRAAVLK 303  Bordetella av...
NP_882638     217 IVDAFTVPFPAAEVWAFMVDLPAVAACLPGAVIEETDg-----QRVKGKIAIKFGPMAAAFNGAARLERDe-EAMRAVFR 290  Bordetella pa...
Feature 1                            ## # #            # # # #              ##### ### ###  #      
YP_644627      79 ASGr----eVNGQGGt--eATITATVsg---sDSKSVLRMDTDLEVRGKVAQFGRGa-IGNVSQRILDQFARNLESQVLS 148  Rubrobacter x...
NP_627846      91 ATE------SRGTGA----VALALTLrad-daEGGATLTFTGTATADGRVAELPPDs-VASAANRLLARFAENLGTAAQA 158  Streptomyces ...
ZP_03543693    78 GTGe----dASVASSlkqtSEVFLTPa----aNGGTDLRIKVNVDVLGRLGAFGLSv-MKTKADRLWEEFGSNLAARIEA 148  Comamonas tes...
YP_873394      79 ANGr----dRNGAGTa--rATVVARLka--lsENRTELALESDVQLTGRIASLGRG--VQDVAGKLFAQFGERMSEALAA 148  Acidothermus ...
YP_558873      81 GKG------ADATGTs--aASMDLVAavq-asGETCELTGRSEVTMSGKAASLGGRl-MGPVSEQMLKQFVANFAARLPA 150  Burkholderia ...
ZP_02188060    79 GRGi----dQRGASHa--lASGTVSAs----gTAETVLTVDGSFSVTGPLEAFANAg-GVHVARALLAEFSTNLTNLVAA 147  alpha proteob...
YP_002780918   79 ARG------RDGQGAtrftAHANFRIte--dhAGGARVQVTGEVALAGKLASVIEAg-AGAVVSRMTNDFTDELVRRCAG 149  Rhodococcus o...
YP_742401     918 GEGg----dTKGSSS----ARMTLQArivpetEAQCRLEGVCTIELTGKLASFGGRm-LENISDRLLSQFVANFENRVAA 988  Alkalilimnico...
CAJ49185      304 GAGtdslsqSRATGNi---AFIVQALd-----ESKTRVSVNLGFSLQGPLAQFSRSglVKDFVGRLIQEFGKNVGLRMDP 375  Bordetella av...
NP_882638     291 GAGqdslsqSRATGDi---AYQVEAVs-----ENETRVKVDLQYALQGPLAQFSRSglVQDFVRRMIADFGKNVTARLRQ 362  Bordetella pa...

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