Conserved Protein Domain Family
SRPBCC_4

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cd07822: SRPBCC_4 
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins
Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
Statistics
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PSSM-Id: 176864
View PSSM: cd07822
Aligned: 89 rows
Threshold Bit Score: 82.3747
Threshold Setting Gi: 15611651
Created: 11-Jul-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        # # #         ### ##                #            # # # #                 # #   
NP_901275     5 SIATQIDIAA-SPERVWRVLTDWRRYPEWN-----PFIVGLHGr-----hEAGARLVATlrppg---grhltFRPRLTAF 70  Chromobacterium ...
EDL69300     20 HVRSQIEIPE-PPEVVWQHLVRAPEWPAWRra--kTMVQILNGdn---tlCKNTMFRWKasg--------feVKCTVVEY 85  Vibrio harveyi HY01
ZP_02881571  19 HFTNELEVSA-SVETIWSLLTDFDSWPAFY-----PGVQHVQPldggdhfGLGTTFETNlag--------qdVFASVQEF 84  Burkholderia gra...
ZP_02881570  19 YALNDIDVKA-PPQVVWKLLVDAERWSRYFpa--eDQVRILSGes---elALGTRYSRVtvg--------ypMSLVVTEC 84  Burkholderia gra...
NP_518264    18 YVSNETIVAGlRAADVWPWLNDTAVWPACYgn--vSDIRFHDGsgp--glRHGARFRFTtfs--------fpVEAEVTEY 85  Ralstonia solana...
EDL54627     21 HVKEEIVVPS-ECERIWACIVQAPCWPNWH-----HRKTAVQI-------TKGDTRELHkgtmfnwitktmsFECTVVEY 87  Vibrio shilonii AK1
ZP_04772320  18 YVSNEVIVPGlTSGDVWPFLVQPSLWPSYYdn--aSDVEIHGGkgp--elALGDTFFFRtfg--------fpVPARVVEC 85  Asticcacaulis ex...
NP_223302    21 FVSNEVIVKGlDFNKVVQHLRDASHWEKYYknsgnIHMYHQDNti----lKDKTRFCFEtfg--------flVEAEVEEF 88  Helicobacter pyl...
YP_617620     3 TVENSISLSA-PLARVWRVLVDVDRYRDWRp----SVGLESDP-------ADPKRLLYTywrpgw-adpvisADARVVRL 69  Sphingopyxis ala...
ZP_01303732   5 RTITSSMLHG-GPLRIWSALTDPDHRRAWS-----PLVFLDDPs------RLGDTECTFaiqgi---trpirTPARIDRF 69  Sphingomonas sp....
Feature 1                 # #                ## # #             # # # #               ##### ### 
NP_901275    71 da-----gaLLAWRGELLvsgl---ldgeHRFRLEAld-----dGGTRLHHGEDFSGIllpl----igggRLERVRQGFL 133 Chromobacterium ...
EDL69300     86 lq-----nqRLAWKGKKGsid------iyHAWVLEPt------kHGCCIITESTQRGGitwl----tkyfAPRRLRKYHL 144 Vibrio harveyi HY01
ZP_02881571  85 ep-----mtRIAWGGYPKvstt---srayHAWIITPt------aSGCHLWTEETMQGPhwle----lakqAPDVFWLTHE 146 Burkholderia gra...
ZP_02881570  85 vp-----nrRLAWATTVDgdetg--ssayHGWVITPt------kEGCHLLTEETQQGQffvel---igsrHPGALYRYHQ 148 Burkholderia gra...
NP_518264    86 eppaggkpaRIAWHGWVEgdaqa-rldvhHAWLFEDlp-----gGRVRILTQETQIGEpare----lartLPNPMLNAHQ 155 Ralstonia solana...
EDL54627     88 ip-----heRIAWKGKCGdvv------myHAWLLSPc------dNGCRIVTESTQRGGlrwl----tgrfVTKQVAAHHQ 146 Vibrio shilonii AK1
ZP_04772320  86 vppvegqaaRIAWHGWAGdvgaedrldvhHAWLIEDls-----yGRVRILTQETQNGApare----lanaRPNPVINGHQ 156 Asticcacaulis ex...
NP_223302    89 elkd--ailRLAWRGWNEakgde-ylevyHAWLVEKld-----nDRVRILTQESQSGVpaka----laksVPNAMLNGHQ 156 Helicobacter pyl...
YP_617620    70 er-----pcRFAWRVGIKgll-----qieEGFYLEKs------pEGTRLTHRLSCWGIgswl-----gfvMRPFLRRRLV 128 Sphingopyxis ala...
ZP_01303732  70 dk-----phAFAWSCGIP-----------YLFTLEEryelagddGGTRLTHSCTLRGAlslpfaammlrrLRSLMVESDD 133 Sphingomonas sp....
Feature 1       ###  #     
NP_901275   134 QMNQALKQRCE 144 Chromobacterium violaceum ATCC 12472
EDL69300    145 RWLEELCRQSH 155 Vibrio harveyi HY01
ZP_02881571 147 KLLRNLAEIAT 157 Burkholderia graminis C4D1M
ZP_02881570 149 DWVECLARAAE 159 Burkholderia graminis C4D1M
NP_518264   156 AWVDGLARSAV 166 Ralstonia solanacearum GMI1000
EDL54627    147 QWLHLLCEQAK 157 Vibrio shilonii AK1
ZP_04772320 157 DWLNGLVQAAR 167 Asticcacaulis excentricus CB 48
NP_223302   157 AWLDGLVAYSR 167 Helicobacter pylori J99
YP_617620   129 RTGGSLARHLR 139 Sphingopyxis alaskensis RB2256
ZP_01303732 134 RLATYLRWRVG 144 Sphingomonas sp. SKA58

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