3CNW,3F08,3KDI,3KAZ,3KDJ,3K90,3KB3


Conserved Protein Domain Family
PYR_PYL_RCAR_like

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cd07821: PYR_PYL_RCAR_like 
Click on image for an interactive view with Cn3D
Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins
The PYR/PYL/RCAR-like family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. PYR/PYL/RCAR plant proteins are receptors involved in signal transduction. They bind abscisic acid (ABA) and mediate its signaling. ABA is a vital plant hormone, which regulates plant growth, development, and response to environmental stresses. Upon binding ABA, these plant proteins interact with a type 2C protein phosphatase (PP2C), such as ABI1 and ABI2, and inhibit their activity. When ABA is bound, a loop (designated the gate/CL2 loop) closes over the ligand binding pocket, resulting in the weakening of the inactive PYL dimer and facilitating type 2C protein phosphatase binding. In the ABA:PYL1:ABI1 complex, the gate blocks substrate access to the phosphatase active site. A conserved Trp from PP2C inserts into PYL to lock the receptor in a closed formation. This group also contains Methylobacterium extorquens AM1 MxaD. The mxaD gene is located within the mxaFJGIR(S)ACKLDEHB cluster which encodes proteins involved in methanol oxidation. MxaD may participate in the periplasmic electron transport chain for oxidation of methanol. Mutants lacking MxaD exhibit a reduced growth on methanol, and a lower rate of respiration with methanol.
Statistics
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PSSM-Id: 176863
View PSSM: cd07821
Aligned: 186 rows
Threshold Bit Score: 62.3415
Threshold Setting Gi: 254385383
Created: 11-Jul-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putativeproteingate
Conserved site includes 44 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # # #        ### ##         # #   #            # # # #        # # #  #      # 
3CNW_A         4 AHTTTSXEIFGSPEQVWQLIGGFNslp-dwLPYIPSSKLTEg------gRVRHLANPDg---DTIIERLEVFNDkeRYYT 73  Bacillus cereus...
3KDJ_A        38 CSSLLAQRIHAPPETVWSVVRRFDrpq-iyKHFIKSCNVSEdfem-rvgCTRDVNVISglpaNTSRERLDLLDDdrRVTG 115 thale cress
ZP_05086427   11 IRCERTMVIDASPEAIWNVIGRYMdld-efAPLVKSVEALTegad-gvgSVRRCHFENg---TFLDEEVLEWEPn-HRMR 84  Pseudovibrio sp...
ZP_05051812    1 MQVTASIEINASVDTAWQVFGEDFegiskwLDAIISSSLDGdla---vgVTRTCNFPKd---LVIKEKLTHFDPktRSLT 74  Octadecabacter ...
ZP_05083926    2 VSIAVHQTVNAPIATVWDSWDDYGnin-kfHPGLNASYLLGkkqktgvgAVRQCDFTDg--kTFLKERISEYLEh-QRIT 77  Pseudovibrio sp...
ZP_05053804    2 TKLTLSRTIQAPADRVWDILADFGgvh-nfHPMVDTSPITNgqdt-glgAERCCELYNg---TKVNEVITSFDPgrRNIG 76  Octadecabacter ...
ZP_01751565    4 CQVSQSLLINVPPANVWGIINAVEgme-dwYPGLIQSSKTTyse---ggVARVCTMANg---GTLNERILLRDTatRTFV 76  Roseobacter sp....
YP_001516586   2 ANVTVYRTIYASLEKVWESWDDFGniy-qfNPNLTHSHLLEdslpkgqgAKRQCDLNDg--kNWIREEVVEYIPy-QQMT 77  Acaryochloris m...
ZP_05050187    2 IKVEKTVLIKAGISQVWDLVSDMGgvy-kyHPLVKKSPVLSenav-gigATRRCEFYDg---NSVVEEIVELKEg-KELK 75  Octadecabacter ...
YP_508044      3 HNIQATREIPATANDLWKTVSQMIgmetscPGLIRESDVLDadg---tqPRRSCVMRNg---GALTERILLRDDatRTFI 76  Jannaschia sp. ...
Feature 1        # #       #  ### # #               # # # #               ##### ### ###  #     
3CNW_A        74 YSIXNa-pFPVTNYLSTIQVKEGTEs-----nTSLVEWSGTFTpve------vsdEEAINLFHGIYSDGLKALQQAFL 139 Bacillus cereus A...
3KDJ_A       116 FSITGg-eHRLRNYKSVTTVHRFEKeeeeeriWTVVLESYVVDvpeg-----nseEDTRLFADTVIRLNLQKLASITE 187 thale cress
ZP_05086427   85 VRMFSmdaLPLKEAQAEICIKPYAGg------KSQINWYLEYRmkygplgwllgqTLVKSGTGKVILGNLKGLAEKVK 156 Pseudovibrio sp. ...
ZP_05051812   75 YAILSglpAFMLKVDNAWTIEDIGNsrs--raTSVVTAKLAWYaip-------lvPMVKIGLGKTLKGALAQLATAVE 143 Octadecabacter an...
ZP_05083926   78 IDIYDt-nAPFRDGKAIFEFTPEGPs------KTRVTMTMSFTpkmg-----ilgKILTPLMKFQFKKGLRGLLKSNA 143 Pseudovibrio sp. ...
ZP_05053804   77 ITVNQp-dPPITAMTGEFTVTPLGDs------GCEVLAIMEYGlidgal-gkeqiDGLRGMMEGAVESVLKGLDDHAV 146 Octadecabacter an...
ZP_01751565   77 YAIDQh-pLPAKNVVGTLRVDDFDG-------HAHVTWSAQFTted------adhNAMSEMVNAMYRNGLSSLSAFAQ 140 Roseobacter sp. CCS2
YP_001516586  78 FNIYEg-tMPLKSAKATLRFRKVMAk------RTEIIMSMDFEprmg-----llgKLMLPMMKPKFTEMLNALLEGND 143 Acaryochloris mar...
ZP_05050187   76 VALSNf-sMPFKSADAIMRLEKASDk------STLVTIQMSYKmkygvfgsilgyFMIKPIMKMTFVKVLKGLNDHVT 146 Octadecabacter an...
YP_508044     77 YAIDSh-pMPAKIVVGTIRIDDLGDg------KSQVSWAADMVlgp------asaDHFAGMVQGMYEGGLASLEAHHT 141 Jannaschia sp. CCS1

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