Conserved Protein Domain Family
SRPBCC_3

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cd07820: SRPBCC_3 
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins
Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
Statistics
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PSSM-Id: 176862
View PSSM: cd07820
Aligned: 78 rows
Threshold Bit Score: 97.6754
Threshold Setting Gi: 70730223
Created: 11-Jul-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        # # #        ### ##                #           # # # #                          
NP_661826      6 KTWVQRLPVPIDVAWDFFSQPGNLARITPPEm--mLKAEG-------GNAGTAIye----gMKLNFVLYPFmmi-pvrWT 71  Chlorobium tepi...
YP_119274     86 IECSIVVPGPRSEVFAWHARPGAFARLAPPWq--pVRLLA-------ETDSLAS-------GRAVLGLPGGl-----rWV 144 Nocardia farcin...
YP_001856036  12 YVHETRLTQPREQVFAWHERPGALPRLTPPFgggpDQVRQaps-dgiEPGSEAKlg---vsVPGTFGMVHLp------WT 81  Kocuria rhizoph...
YP_002779471   3 IVHSSVVEASRDELFAWHTRAGAFTRLSPPWq--pLSLAK-------ESESLES-------GRAELRLPGGl-----tWI 61  Rhodococcus opa...
NP_738344      3 LTTSHFIPFPREEVWDWHTRKGAVTRLSPPFv--pFTPIQ-------QAERLSD-------GTTIFSLPAGl-----kWV 61  Corynebacterium...
ZP_04000276    4 YTRCTRIGAPLSTIWEFHSDESGLEALTPDWm--gLDIVSv-----rGPDGTLDpetldagSKIRMSMRPFdvgpaqrWT 76  Halogeometricum...
YP_002566176   4 YRRTTRVPAPIDEVWAFHSTIDGLRELTPDWm--hLQIAGvegpdgePDPDVLTe-----gSQIRMSIRPFgvgprqrWT 76  Halorubrum lacu...
ABQ75825       4 YHRRTTVEAPFSQVWEFHSQISGLEALTPSWm--fLSIDSvh----yPEPSAAQsktlvrdSEIEMSMRPLgvlprqhWV 77  uncultured halo...
YP_002834705   3 FTTQHVVPAPREEVWQWHTRPGALARLTAPFg--fMTPLQ-------QAESLAD-------GTSILGFPGGl-----kWV 61  Corynebacterium...
NP_280030      4 FKRDLRVDAPLESVWAFHSTVDGLLALTPEWa--nLTVEDvvwpqgqRDGDELVa-----gTRINMAVEPFgvgprqtWT 76  Halobacterium s...
Feature 1        # #                               # #      ## # #      # # # #        ##### ### 
NP_661826     72 TEIMKVs--------kPDFFEDRQl--------sGPYEQWYHRHLFRDIEG-GTEMTDIVEYAl--PFDLFGEVVEALIV 132 Chlorobium tepi...
YP_119274    145 ARHDPQey------rpPCRFVDAVaaeepasmpvGRVLRWRHIHDFEDVDGtHTRVIDRVRTPi--PEAVLRPMFAYRHR 216 Nocardia farcin...
YP_001856036  82 AEHGEWd--------pPHYFTDRMa--------kGPLGEWEHRHVFEETEAgGTLIQDRVTVRplpQWAGRLNDVGERVM 145 Kocuria rhizoph...
YP_002779471  62 AQHDAKey------dpPHRFVDYSaal-----plRLLVPWRHTHTFDVVSEgRTRVTDRVDTIv--PGQFLRSTFVYRHR 128 Rhodococcus opa...
NP_738344     62 ARHDLSgy------lnGSRFTDVCvna-----pvKALANWRHVHNFVDQDG-GTLITDSVSTRv--PGIALTSMFAYRQH 127 Corynebacterium...
ZP_04000276   77 SHIVAReld-----dyTAMFRDEMi--------gGPFKKWVHTHRFYADGE-KTLMEDHVEYEf--PGGGVGRAVSPLGI 140 Halogeometricum...
YP_002566176  77 SRITERdphdetalgdRAHFIDEMv--------gGPFRTWEHTHAFYADVE-ETLLVDTVAYRl--PFGPLGDAAGPFAK 145 Halorubrum lacu...
ABQ75825      78 SRIIARern-----dtTGYFIDKMi--------gGPFQQWEHTHRFFADGE-QTILDDQVEYQl--PGGRLGRRMSVLGL 141 uncultured halo...
YP_002834705  62 ARHDLSry------qpRRSFADVCina-----pfRSLANWRHEHFFEDHPE-GTLITDKVDTRi--PTGPVESIFAYRQQ 127 Corynebacterium...
NP_280030     77 SVITERate-----ddHAYFVDTMe--------nGPFPEWEHTHSFYADGD-QTVLRDRVAYEp--PLGGLGAVGAPPVL 140 Halobacterium s...
Feature 1         ###  #     
NP_661826    133 GPRLDEVFEYRR 144 Chlorobium tepidum TLS
YP_119274    217 QLADDLRAHRRA 228 Nocardia farcinica IFM 10152
YP_001856036 146 TPQLNRIFAYRE 157 Kocuria rhizophila DC2201
YP_002779471 129 QLADDLDRHHWA 140 Rhodococcus opacus B4
NP_738344    128 QLLEDMLALQRF 139 Corynebacterium efficiens YS-314
ZP_04000276  141 IGLEPMFRQRHA 152 Halogeometricum borinquense DSM 11551
YP_002566176 146 VGFEGMFQDRHR 157 Halorubrum lacusprofundi ATCC 49239
ABQ75825     142 IGFEAMFRGRHR 153 uncultured haloarchaeon
YP_002834705 128 QLIEDFRFAQRL 139 Corynebacterium aurimucosum ATCC 700975
NP_280030    141 WGMFRFRHRQTR 152 Halobacterium sp. NRC-1

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