Conserved Protein Domain Family
SRPBCC_1

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cd07818: SRPBCC_1 
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins
Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
Statistics
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PSSM-Id: 176860
View PSSM: cd07818
Aligned: 74 rows
Threshold Bit Score: 110.434
Threshold Setting Gi: 87120448
Created: 11-Jul-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # # #        ### ##          #             # # # # #            # #          
YP_550716    26 TFRVQRSASIKAAPDTLYPLINDLRQFNTWNPYEKKDPAIkgsyRGPASGPGAGYDFQGNkdvGKGSIEIVESs------ 99  Polaromonas sp. ...
NP_800584     5 AYQVSKSIEINKSQSEIIDYLKDFKNWPEWSPWIILEPSCeltySDNQGHVGAGYQWNGQr-iGTGAVVLESTq------ 77  Vibrio parahaemo...
NP_868346    41 AFHIQRSQTIDADTRDVYDAVRDYSTWTRWSPWLQVDPDAevtvSDPSNELGATYHWKGEl-vGEGSMTHRQLqapksls 119 Rhodopirellula b...
ZP_01113579   3 AYNVERSIEIERPAQEVIDYLSDFRHWPIWSPWLIMEPDCevtyQGTPGEVGAGYHWSGKl-vGEGRMTLASRs------ 75  Reinekea sp. MED297
EDL55792      3 NYTVEKRIDIESTADHVIEFLADYRNWPEWSPWLIMERECkldyRGEQGNIGDGYSWHGDl-vGSGEMTLMKRt------ 75  Vibrio shilonii AK1
NP_762014     7 GTCVSRSIYIDRKPEKVIDYISDFGTWAKWSPWLILEPKSevtfSTFQQQPGAQYAWKGEr-iGAGKMELAHLy------ 79  Vibrio vulnificu...
ZP_05058459   3 KFDLERAITIEASAVAVFSYVKNFRDWRQWSPWILAEPNC----KLEYAEDGSSYSWAGDi-iGAGEMELLEAe------ 71  Verrucomicrobiae...
YP_339040    23 SYNVTKSININANTHIVKPLITDFSQWHKWSPWKKLDPSVefslGEPSTGVGAHQSWQSKw--GAGEMTTTALs------ 94  Pseudoalteromona...
ZP_01612141  30 DYRASKHVEINANTSTIKTLVADFNQWHTWSPWQQVDPTIefivNEPGAGVGAHQSWVGKw--GYGEMTITSLn------ 101 Alteromonadales ...
ZP_01133634   9 HYKIEKSIQIEATASALNYWLFDLNNWPTWQVFQMLSPDLnfvfGEKTKGVGAFLAWQGPy--QTGELTFSKVd------ 80  Pseudoalteromona...
Feature 1           # #             ## # #            # # # #              ##### ### ###  #     
YP_550716   100 pPGKVTMKLDMLEPfeghNVVEFSLAPr-----GDATEVTWAMHGPSPFvarlvgvfLNMDRMIGRDFEAGLANLKARAE 174 Polaromonas sp. ...
NP_800584    78 -EHRLDMELHFFRPikshGKVTLIVTPs-----QDGCTVEWQMQSRVPWylf--flkTMFKSMVEMDYDRGLKMLKSQLE 149 Vibrio parahaemo...
NP_868346   120 aNASVQADLAFVKPfksqSKVEFEIEPvmt-dgRPGSKITWHMRGKLPWflf--wmrSMMETFVGMDYERGLLMFKQFVE 196 Rhodopirellula b...
ZP_01113579  76 -DSELRIPLEFIRPfrsnAQADFHILPl-----NGRTQVTWTLSAKLPFflf--flkATMEQSLGMDYERGLRMLKSQLE 147 Reinekea sp. MED297
EDL55792     76 -SHQLEMHLRFFKPfkseAHVSFQAVQm-----GARSEVRWTMSSQVPWylf--flkGLFKTMIGMDYDRGLKMLKAKLE 147 Vibrio shilonii AK1
NP_762014    80 -DHQLVFRLSYLKPfkgeAEVYFNVSPe-----QQGCRVEWQFQGKLPWymf--ffrQMFGAVLGMDYARGLRMLKSAIE 151 Vibrio vulnificu...
ZP_05058459  72 eGKALHYRLTFLKPwkstSSVSFYFEEc-----REGTNTRWTMEGSLPFflf--wmkRMLIAGVGMDYDRGLLMLKDQIE 144 Verrucomicrobiae...
YP_339040    95 -ANKMVLNILFAQEh--iIAANVIFTQn-----AKTVTVTFQITGQATLplvsgyvaVLSEHILSNAVSLGLNNLKTVAQ 166 Pseudoalteromona...
ZP_01612141 102 -NDKMSFNILLNNEh--iIEGTLTFSPq-----ENANTVTCYIEGQSTTllisgymaLVYEYILSNTLELGLNNLKTVAQ 173 Alteromonadales ...
ZP_01133634  81 -ERNIQFNVLFNDEh--lAFGNLNIEPimlksdVTKQLVNWSLEGEINTpifagylaLFHNIVLSSALETGLKNLQAQAE 157 Pseudoalteromona...
Feature 1        
YP_550716   175 R 175 Polaromonas sp. JS666
NP_800584   150 T 150 Vibrio parahaemolyticus RIMD 2210633
NP_868346   197 T 197 Rhodopirellula baltica SH 1
ZP_01113579 148 T 148 Reinekea sp. MED297
EDL55792    148 I 148 Vibrio shilonii AK1
NP_762014   152 T 152 Vibrio vulnificus CMCP6
ZP_05058459 145 L 145 Verrucomicrobiae bacterium DG1235
YP_339040   167 L 167 Pseudoalteromonas haloplanktis TAC125
ZP_01612141 174 L 174 Alteromonadales bacterium TW-7
ZP_01133634 158 I 158 Pseudoalteromonas tunicata D2

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