3GGN


Conserved Protein Domain Family
SRPBCC_8

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cd07817: SRPBCC_8 
Click on image for an interactive view with Cn3D
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins
Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
Statistics
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PSSM-Id: 176859
View PSSM: cd07817
Aligned: 81 rows
Threshold Bit Score: 109.231
Threshold Setting Gi: 219111967
Created: 11-Jul-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 38 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #        ### ##              #     # # # #            # #  #     # #       
3GGN_A         5 VVRDAVTIGKPAEQLYAVWRDLPGLPLLMTHlrSVEVLDdKRSRWTVEAPapLGTVSWEAELTADEpGKRIAWRSLPGar 84  Deinococcus rad...
YP_833442      4 KVEKRILVNVPASTAYNQWTQFEEFPHFMGGvkSVTQLSdDRLEWVAEIA--GVRRKWEAKILEQVpDRKVAWAATEGa- 80  Arthrobacter sp...
NP_821245      4 SLVETVDIEAPVAVTWALWSDVSRWPSFLSHvrLVEPLDeRRFAWQLSLP--GADKNFVAELTEVIpGDRIAWQTTEGv- 80  Streptomyces av...
YP_544119      3 IIEKSIEVNVPAQVAYDQWTQFEDFPLFMDGivEVTQLDdTHLHWKADVA--GQRKEWDAEITEQIpGKRIAWRSISGa- 79  Methylobacillus...
YP_412222     33 SVENFIEVNVPVSTAYNQWTQFEEFPRFMKGvrEVQQIDdTHLHWRAEIA--GKEEEWDAEITEQVpDQRIAWHSTNGa- 109 Nitrosospira mu...
YP_544770      3 RLENTIDIKVPVNIAYNQWTQFETFPNFMSSvlQVKQLDdSHVWWQVEIG--GHAIEWETEIIEQVpDDHIAWRSVSGp- 79  Methylobacillus...
ZP_02926949    3 SVEESIRIERPVKVVYDQWTQFEDFPHFMEGvkEVRQIDdSHLHWEVEMG--GFIKTWEAEIIEQVpDQFIAWQSTHGp- 79  Verrucomicrobiu...
YP_002007880   3 TIEESIDVRVPAQVAYRQWSRFEEFPRFMEGveEVKQLDdRRLHWRAEVG--GKHKEWDAEITQNVaDQCIAWRSVAGa- 79  Cupriavidus tai...
ZP_03626264    3 HIEKTIEVEAPVNKVYNQWTQFEDFPEFMEGveEVRQLDdKHLHWVAEIG--GKKKEWDAEIYEQVpDQKVAWRSITGa- 79  bacterium Ellin514
YP_464169     14 RVEKSIEIDRPVRTVYDQWTQFEEFPRFMEGveAVHQLDeRTLHWVAKIA--GKREEWEAEIVQQMpDQQIAWRHTRGa- 90  Anaeromyxobacte...
Feature 1           ## # #          # # # #              ##### ### ###  #      
3GGN_A        85 ieNSGEVLFRPAPgarGTEVVVRLTYRPPGGsagaviarMFNQEPSQQLRDDLMRFKREQEL 146 Deinococcus radiodurans R1
YP_833442     81 -tNAGTVTFEDVGg-gQTSVQLSLEYQPEGIvet---igDKLHVVDRQVEGDLKRFKDFIED 137 Arthrobacter sp. FB24
NP_821245     81 -hHAGVVTFHRLSd-tSSRVTLQIEYDPKGFveh---igALTNLDSTLANYDLGEFQKLAET 137 Streptomyces avermitilis MA-4680
YP_544119     80 -rNAGVVTFHHLDa-sTSRIMLQMDYDPEGLlen---agDALGVLTHRVNGDLERFKEFIES 136 Methylobacillus flagellatus KT
YP_412222    110 -kNSGVVSFYGISd-sKTRVVLKMDYGPRTFleg---lgDALGAVKARTSEDLRCFKEFLES 166 Nitrosospira multiformis ATCC 25196
YP_544770     80 -rHLGLVSFKHVDi-hATRVHVEIEYEADMKaev---saTMTGLLEQKISEALTCYRQLLES 136 Methylobacillus flagellatus KT
ZP_02926949   80 -rSSGRVTFEPLAd-dATMVSLRMAYTPEGVven---lgALLRLVSLRIARDLQCFKDFIEA 136 Verrucomicrobium spinosum DSM 4136
YP_002007880  80 -qNAGQVNFTPLDa-gATRVSVRMDYETEGVvea---vgDAAGVLKRRVEGDLKRFKEFIEA 136 Cupriavidus taiwanensis
ZP_03626264   80 -rNAGMVEFIPQEs-nLTRVILKMDYEPQGAvek---tgDVLGAVSRRVEGDLERFKHFIQS 136 bacterium Ellin514
YP_464169     91 -vNRGVVTFTPIDd-gRCRVTLALEYDPQGFvek---agDVLGVVSRRVEGDLERFKRYIEE 147 Anaeromyxobacter dehalogenans 2CP-C

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