2GKD,1X53,1XUV,1Z94,1XFS,2IL5,1XN5,3ELI,2GKC,1XN6,2KEW,2NN5


Conserved Protein Domain Family
SRPBCC_CalC_Aha1-like

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cd07814: SRPBCC_CalC_Aha1-like 
Click on image for an interactive view with Cn3D
Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins
This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.
Statistics
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PSSM-Id: 176856
View PSSM: cd07814
Aligned: 232 rows
Threshold Bit Score: 45.8176
Threshold Setting Gi: 81416877
Created: 20-Jun-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 43 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hydrophobic ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # # #        ### ##    #                #         # # # #         # ## #  #    
2GKD_A         5 FVRHSVTVKADRKTAFKTFLe--GFPEWwpnnfrttkvgapLGVDKKG---GRWYEIDeqg----eeHTFGLIRKVDEpD 75  Micromonospora ...
2IL5_A        15 EVEIEKLYKFSPELVYEAWTkkdLLKQWfxtsa---rtnkeIEADVKEg--GKYRIVDqqrn-gkvnVIEGIYESLVXdE 88  Staphylococcus ...
Q98FH6        10 TFIIERLYPAPPSKVFFALGnadAKRRWftdpdn--pmpgrFEMDFRVg--GKEVNAGgpkd-gpihVYTATYQDIVPdQ 84  Mesorhizobium loti
YP_002634911  12 VISLERLMRINPELIYQAWTdadVMRRWfmts-----nrsnKSIDLIPeegRRYEIVDerng--ktnKITGVYQELEApN 84  Staphylococcus ...
ZP_04696584    8 GIDLTRVLDAPQQRVFAAWTspeDFAAWyggead--vpldrVAMDVRPg--GSWRLVIvmpg--vemPFHGVYREVSEpD 81  Streptomyces ro...
YP_300669     12 EIRLERLFKVEPELLYQAWTderFLKQWfmtte---rtnksIQVDAEQn--GNYTIIDvrkg--kenKIQGSYRTLTPfE 84  Staphylococcus ...
YP_001109390  11 EFTITREFDAPREAVWRAWTdpaEMTHWyhprgf-atppesISVDLREg--GTYRYTMvdektgeqyPTGGTYLEIAEpE 87  Saccharopolyspo...
YP_002768556  11 EFTITRIFDAPRDLVWRAWTdpdEAARWwhpegv-ssprehVTIDPRVg--GTYRYLMindengaefPTGGTYLEVDEpK 87  Rhodococcus ery...
ZP_04175126    8 TLTMVRDFDVAPEEIFEAWInpdMMKKWfftle----gtnkITKNTPEv-gGSWEIVDhrng--kdyRAIGEYIEMNRpK 80  Bacillus cereus...
YP_302267      7 NLDMTFKVDAPVEEVFRAWTkpsLFKQWfmtte----etnkVAKNQFEi-nGDWEIIDvreg--veyRAIGTYIDIVSpY 79  Staphylococcus ...
Feature 1         # ##               ## # #            # # # #                  ######### ###  # 
2GKD_A        76 TLVIGWrlngfgridpdnsSEFTVTFVAdg--qkKTRVDVEHTHFDRmgtk--------hakrVRNGMDKGWPTILQSFQ 145 Micromonospora ...
2IL5_A        89 YVKXTIgxpgl----setqDVIEVEFFEre--tgGTQXLFYYRSLVEkerrftnleykqkkkeYHDAXVHGFELXFDKXY 162 Staphylococcus ...
Q98FH6        85 RIVYSYdmlfge--trisvSLATIQLFAeg---eGTRLVLTEQGAFLdg------------hdTPSTREHGTGVLLDLLD 147 Mesorhizobium loti
YP_002634911  85 RIVMTIgmpel----sdkeDTIEVEIFErepgsdITQMNFQYTAVVPkerrwttleykqqkkeYHDSTAHGFENMFVKLQ 160 Staphylococcus ...
ZP_04696584   82 GLVFTLkdgsap--edaegETVTVTFSDlg--ggRTELAFQQRGGNLtp-------------eQYAAAEDGWEAFFDALA 144 Streptomyces ro...
YP_300669     85 YIVMTIgmpel----sdseDTIEVEIFEre--pgITQMIFNYTAYVPrerrlttleykqkkkeYHDSTAHGFEMLFDKLQ 158 Staphylococcus ...
YP_001109390  88 RLVFTWgdlde---saesaPVVTVTLQErg---eRTAMTFHLRGIAGh--------------pGDGYVHDGWAEALDLLI 147 Saccharopolyspo...
YP_002768556  88 KLVFTWgdpgd---svdtaPRITVTLADrg---dKTEMTFHLVGIPGf--------------kGDGNVYDGWESAFDVLD 147 Rhodococcus ery...
ZP_04175126   81 KLAFTFkmpqf----geleDTITVEIMEkq---qGSEMIFSQNIIVPheenwtksdvekalkdYHDGSEHGWNLMFMGLK 153 Bacillus cereus...
YP_302267     80 KLTFSFkmpqf----seleDIITVEFVDlt---gATEVKFNQGIKVPfegdtnd--feadkteVKKEMETGYNLMFERLK 150 Staphylococcus ...
Feature 1             
2GKD_A       146 DKIDE 150 Micromonospora echinospora
2IL5_A       163 HVIET 167 Staphylococcus aureus
Q98FH6       148 AFLDK 152 Mesorhizobium loti
YP_002634911 161 DILTE 165 Staphylococcus carnosus subsp. carnosus TM300
ZP_04696584  145 DRLAT 149 Streptomyces roseosporus NRRL 15998
YP_300669    159 IALET 163 Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
YP_001109390 148 EHLTG 152 Saccharopolyspora erythraea NRRL 2338
YP_002768556 148 KVYRG 152 Rhodococcus erythropolis PR4
ZP_04175126  154 ELVET 158 Bacillus cereus AH1273
YP_302267    151 QLCEG 155 Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

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