1T17


Conserved Protein Domain Family
COQ10p_like

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cd07813: COQ10p_like 
Click on image for an interactive view with Cn3D
Coenzyme Q-binding protein COQ10p and similar proteins
Coenzyme Q-binding protein COQ10p and similar proteins. COQ10p is a hydrophobic protein located in the inner membrane of mitochondria that binds coenzyme Q (CoQ), also called ubiquinone, which is an essential electron carrier of the respiratory chain. Deletion of the gene encoding COQ10p (COQ10 or YOL008W) in Saccharomyces cerevisiae results in respiratory defect because of the inability to oxidize NADH and succinate. COQ10p may function in the delivery of CoQ (Q6 in budding yeast) to its proper location for electron transport. The human homolog, called Q-binding protein COQ10 homolog A (COQ10A), is able to fully complement for the absence of COQ10p in fission yeast. Human COQ10A also has a splice variant COQ10B. COQ10p belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.
Statistics
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PSSM-Id: 176855
View PSSM: cd07813
Aligned: 169 rows
Threshold Bit Score: 104.861
Threshold Setting Gi: 45644758
Created: 11-Jul-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 38 residues -Click on image for an interactive view with Cn3D
Feature 1:putative coenzyme Q binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        # # #        ### ##              #             # # # #          # # #      # #  
1T17_A         4 HVVTKVLPYTPDQLFELVGDVDAYPKFVPWITGMRTWNGRVdgavSTVDAEAQVGFsfLREKFATRVRRDkdARSIDVSL 83  Caulobacter vib...
CAM75492       4 HAEKRPLPYTPDQLFDLVADVERYPEFLPWCVGARIRKRDG----DMFFADLVIGFkmIRERYTSKVVLDraAMRIDVTY 79  Magnetospirillu...
ZP_01302985    4 HNETRHLPYTPAQMFDLVSNVAAYPEFLPWVSAIRVRQDGE----REMVADMIVGFkgIKESFTSRVLKEr-PDHVRVDY 78  Sphingomonas sp...
YP_162866      4 YTESKILPYTPQQLFDLVADISRYPEFLPWVIAVRIRSREE----NRMTADLIVGFkaFRESFTSKVTLDs-PHSVSVEY 78  Zymomonas mobil...
YP_458150      4 IRDKRHLPYTPEQMYDLVADVSRYEEFLPWVIATRVRSDTD----TEMVADMVVGFknLRERFTSRVEKEr-PDFIRVHY 78  Erythrobacter l...
YP_616327      4 HHETRDLPYSAEQMFALVTDIARYPEFLPWVIALRIRSDSE----HESVADMIVGFkgLRESFSCRVHKQr-PHEVIVSY 78  Sphingopyxis al...
ZP_01017505    4 HQERTFVPFTPTQMFDLVAAVEDYPRFIPWIEALRVKERKA----EHLVADMIVKYtiFRESFRSRVALDrpNMAIDVDY 79  Parvularcula be...
YP_001260751   4 HRETRTLPYSPEQMYALVADVASYAEFLPWVSAVRVRSDSE----TEMVADLMVGFkaLREKFTSKVSKQr-PASIHVDY 78  Sphingomonas wi...
YP_510173      4 HSETRQLPYTAKQMYDLVADVAKYPDFIPWTIATRVKSVEPvddhAVMHADMVVGFrmFREKFLSRVALWeaEGKIDTEY 83  Jannaschia sp. ...
YP_001414399   4 HEHVRDVPYAPEEMFSLVAGIDRYPEFLPWCSGARIRRREMengkEVLLADLIVSYkvFREQFTSRVTLDreAFIIDVGY 83  Parvibaculum la...
Feature 1                ## # #         # # # #          ##### ### ###  #       
1T17_A        84 LygpfKRLNNGWRFMPEg-dATRVEFVIEFAFKSallDAMLAANVDRAAGKLIACFEARAQQL 145 Caulobacter vibrioides
CAM75492      80 TegpfQYLNNHWSFVPNadgTTTIDFFVDFEFKSkilQKVIGSLFNEAVKLMVGAFEKRAGQL 142 Magnetospirillum gryphiswaldense...
ZP_01302985   79 LdgplKHLHNEWQFRDDgqgGVLVDFEVEFEFKNrifEMLAGQFFDKALRKMIGAFEERAAEL 141 Sphingomonas sp. SKA58
YP_162866     79 IdgplSHLHNEWHFTEEgegKTRLDFMVDFSFRSrifEALAGQFFDRAVQKMTQAFEERANNL 141 Zymomonas mobilis subsp. mobilis...
YP_458150     79 VdgplRDLDNTWQFSPYgeqSCTVDFCVDFSFKNrvfEAVAGQYFDRAFRRMVEAFEARAADL 141 Erythrobacter litoralis HTCC2594
YP_616327     79 IdgpmKHLSNEWHFQPAaggGCRVDFMVDFSFRNrmfEALAGQMFDKALRKMIAAFEARADEL 141 Sphingopyxis alaskensis RB2256
ZP_01017505   80 IrgplKSLSNHWRFEKEp-nGCTIDFCIDFEFKNpllQTVANQLIDKAFRRLSSAFTDEAHRR 141 Parvularcula bermudensis HTCC2503
YP_001260751  79 VdgplKFLHNDWAFAADgkgGSIVDFSIDFEFRSrlfEMIAGQMFDRALRMMINAFEERAAKL 141 Sphingomonas wittichii RW1
YP_510173     84 VdgpfKYLISNWEFTDTe-tGCDVHFKVDFEFKNrllQGAAGLFFMDAMQRIVRAFEKRADAL 145 Jannaschia sp. CCS1
YP_001414399  84 VqgpfSYLHNNWRFEPLpdgGTRIHFCIDFEFRSatlQKMIGAVFSKAFGRMMEAFIARADEL 146 Parvibaculum lavamentivorans DS-1

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