1EM2,1EG9,1T17,1UW5,2B79,2D4R,2FFS,2GKD,2KF2,2PCS,3CNW,3GGN,3IE5,1LN3,2DE7,2DE7,1FM4


Conserved Protein Domain Family
SRPBCC

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cd07812: SRPBCC 
Click on image for an interactive view with Cn3D
START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
SRPBCC domains have a deep hydrophobic ligand-binding pocket; they bind diverse ligands. Included in this superfamily are the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), as well as the SRPBCC domains of phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of this superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.
Statistics
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PSSM-Id: 176854
View PSSM: cd07812
Aligned: 195 rows
Threshold Bit Score: 34.9916
Threshold Setting Gi: 226192803
Created: 20-Jun-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
hydrophobic
Conserved site includes 37 residues -Click on image for an interactive view with Cn3D
Feature 1:hydrophobic ligand binding site
Evidence:
  • Comment:binds large hydrophobic compounds such as lipids, hormones and antibiotics
  • Structure:1UW5_A; human PITPNA bound with PtdIns, contacts at 4A
    View structure with Cn3D
  • Structure:1LN3_A; human STARD2(PC-TP) binds palmitoyl-linoleoyl-PtdCho, contacts at 4A.
    View structure with Cn3D
  • Structure:2DE7_C; Janthinobacterium oxygenase component of carbazole 1,9a-dioxygenase binds carbazole, contacts at 4A.
    View structure with Cn3D
  • Structure:1FM4_A; birch pollen allergen Bet V 1-L binds deoxycholic acid, contacts at 4A.
    View structure with Cn3D
  • Comment:Bet v 1-L is believed to be involved in the transport of plant steroids. Although deoxycholate is not the natural ligand for Bet v 1, it is structurally very similar to the plant steroids, brassinosteroids.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     # # #                 ### ##                                   #                
1EM2_A     68 FILKTFLpc---------pAELVYQEVIlqperxvl--------------------wnktvtaCQILQrve-------dn 111 human
1EG9_A    187 GKVVIKAn-----------WKAPAENFVgdayhvgwthasslrsgesifsslagnaalppegaGLQMTsky--------g 247 Pseudomonas putida
1UW5_A      5 KEYRVILpv---------sVDEYQVGQLysvaeask-------------------netgggegVEVLVnepyekdgekgq 56  human
2FFS_A      3 FEHLVQVndrtlvdlpvldRLQLWEGLVcrarepqy--------------------fvvglerFEILVddg--------d 54  Pseudomonas aerugi...
3IE5_A     12 IVKEEESpi---------aPHRLFKALVlerhqvlvk------------------aqphvfksGEIIEgdg-------gv 57  Hypericum perforatum
1LN3_A     54 YKVFGVLed--------csPTLLADIYXdsdyrkq---------------------wdqyvkeLYEQEcn---------g 95  human
2DE7_A    163 KNQIIKSn-----------WRLAVENGFdpshiyihkdsilvkd---ndlalplgfapggdrkQQTRVvdddv---vgrk 225 Janthinobacterium
YP_413406   8 IDLNFAVsa---------nPREVWDVLTdfdrmad---------------------fvsnlkeSKVVSi----------- 46  Nitrosospira multi...
CAL50236  260 ALAAVRVea---------pPALIWDLLTtyenmpq---------------------yvphlmhVEFIQr----------- 298 Ostreococcus tauri
1FM4_A      5 YETEATSvi---------pAARMFKAFIldgdklvpk------------------vapqaissVENIEgng-------gp 50  European white birch
Feature 1      # # # #                                         # # #                  # #     
1EM2_A    112 tLISYDVSagaaggv---------------------------vsprdfVNVRRIerrr----------drylSSGIAtsh 154 human
1EG9_A    248 sGMGVLWDgysgvhsadlvpelmafggakqerlnkeigdvrariyrshLNCTVFp-----------------NNSMLtcs 310 Pseudomonas putida
1UW5_A     57 yTHKIYHLqskvptfvrx---------------------lapegalniHEKAWNay--------------pyCRTVItne 101 human
2FFS_A     55 rLHRRLYLpgl-----------------------------------vvEDEVVLkap-------------dsAHYSIkps 86  Pseudomonas aerugi...
3IE5_A     58 gTVTKITFvdghp-------------------------------ltymLHKFDEidaa-----------nfyCKYTLfeg 95  Hypericum perforatum
1LN3_A     96 eTVVYWEVkypfpx-----------------------------snrdyVYLRQRrdldxe------grkihvILARStsx 140 human
2DE7_A    226 gVYDLIGEhgvpvfegtiggev-------------vregaygekivanDISIWLp-----------------GVLKVnpf 275 Janthinobacterium
YP_413406  47 -SEDKFTIfqngtaty------------------------gpirypfeSIREVRlipy-----------hkiLTHLVsgn 90  Nitrosospira multi...
CAL50236  299 -YNAKINPsegedvkr------------------------lrlrhvfvKCELFHaveeavgmdvvqkddrteLQFRIlqn 353 Ostreococcus tauri
1FM4_A     51 gTIKKINFpegfp-------------------------------fkyvKDRVDEvdht-----------nfkYNYSVieg 88  European white birch
Feature 1                         ## # #                                                      
1EM2_A    155 sakppt-----hkyvrgengPGGXIVLksas------------------------------------------------- 180 human
1EG9_A    311 ------------------gvFKVWNPId---------------------------------------------------- 320 Pseudomonas putida
1UW5_A    102 yxk------------edfliKIETWHKpdlgtqenvhklepeawkhveavyidiadrsqvlskdykaeedpakfksiktg 169 human
2FFS_A     87 ae--------------vaggSLDXTIEepe-------------------------------------------------- 102 Pseudomonas aerugi...
3IE5_A     96 dvlr----------dniekvVYEVKLEav--------------------------------------------------- 114 Hypericum perforatum
1LN3_A    141 pqlger-----sgvirvkqyKQSLAIEsdg-------------------------------------------------- 165 human
2DE7_A    276 pn-------------pdmmqFEWYVPId---------------------------------------------------- 290 Janthinobacterium
YP_413406  91 mhkldgttyltdetggtrvvHRTEAIPkvwi------------------------------------------------- 121 Nitrosospira multi...
CAL50236  354 pkf-----------galqgkWLVVPTEds--------------------------------------------------- 371 Ostreococcus tauri
1FM4_A     89 gpvg----------dtlekiSNEIKIVatp-------------------------------------------------- 108 European white birch
Feature 1                           # # # #                     #####        ##  ###  #    
1EM2_A    181 ----------------nprVCTFVWILNTDlkgrl-----------prylIHQSLA-------ATXFEFAFHLRQRI 223 human
1EG9_A    321 -------------------ANTTEVWTYAIvekdmp--------edlkrrLADSVQrtfgpagFWESDDNDNMETAS 370 Pseudomonas putida
1UW5_A    170 rgplgpnwkqelvnqkdcpYXCAYKLVTVKfkwwg-----------lqnkVENFIH-------KQERRLFTNFHRQL 228 human
2FFS_A    103 -----------------pgSLFVRFAYCTRylqpl----------gdelpYDAFVK-------QAYIAXDVETIATI 145 Pseudomonas aeruginos...
3IE5_A    115 -----------------ggGSKGKITVTYHpkpgc----------tvneeEVKIGE-------KKAYEFYKQVEEYL 157 Hypericum perforatum
1LN3_A    166 -----------------kkGSKVFXYYFDNpggqi-----------pswlINWAAK-------NGVPNFLKDXARAC 207 human
2DE7_A    291 -------------------ENTHYYFQTLGkpcandee-----rkkyeqeFESKWKpma--leGFNNDDIWAREAMV 341 Janthinobacterium
YP_413406 122 ----------------pavVGKVFIEHEVReqf--------------nemRNEIIR-------RKRAALKKGHEKQD 161 Nitrosospira multifor...
CAL50236  372 ------------------kASVLKFAIEGVvrrendmgakvldplnerivFEEISTm-----lKQARDFMENIANME 425 Ostreococcus tauri
1FM4_A    109 -----------------dgGCVLKISNKYHtkgnh----------evkaeQVKASK-------EMGETLLRAVESYL 151 European white birch

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