Conserved Protein Domain Family
DdPDE5-like_MBL-fold
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cd07738: DdPDE5-like_MBL-fold 
Dictyostelium discoideum phosphodiesterase 5 and related proteins; MBL-fold metallo hydrolase domain
Includes Dictyostelium discoideum cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase A (also known as cyclic GMP-binding protein A, phosphodiesterase 5, phosphodiesterase D, and PDE5) and cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B (also known as cyclic GMP-binding protein B, phosphodiesterase 6, phosphodiesterase E, and PDE6. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293824
Aligned: 11 rows
Threshold Bit Score: 275.328
Created: 7-Jul-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative active site [active site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                 # # ##               
Q8MLZ3     344 TIIGSsHGFDPkk--sTTGFVLWIn-kRGIMVDPPLnss-sfLQSQGVPTRMVDHIILTHCHADHDSGTFQKLLee-yqI 418  Dictyostelium di...
Q8MM62     516 TFLGVsHGLDFthcshTTGFIIWIn-gSGVVVDPPVgnt-tyLQTNGIYGKTVEHIILTHCHADHDSGILQKIIer-nkV 592  Dictyostelium di...
NP_712110  208 TCLGPsHGFDPed--nTSGFIIWLn-hQGIMVDPPVnst-ewLRQSNVNPKLINHVILTHCHADHDAGTFQKILee-nkI 282  Leptospira inter...
EEY69474   181 TVLGNsHGFDPng--kTSGYVLWIn-hRGIMIDPPPfss-siLSANNIPALMIDGVILTHCHADHDAGTFQKILqe-grV 255  Phytophthora inf...
CAK89179   286 TVLGCsHGFDPkg--sVSGYIFWIn-gLGVMLDPPPftt-llLRKNGIPSRLVKWVIISHNHADHDSGTFQKLLes-ekT 360  Paramecium tetra...
EGG20846   492 SFLGTsHGFDPyg--hTTGFIIWIn-gNGILVDPPIgtt-tyLKSKGISHKLVDQVILTHCHSDHDSGILQKIVes-ekI 566  Dictyostelium fa...
EMS77565   214 TTLGSgHGFDPda--mTSGMIIWIn-qRGIMVDPPVnsa-vdLIRLGVNPKILDAIILTHCHADHDSGTLQKIMle-gkI 288  Desulfotignum ph...
EOD20995    65 TVLGAaDGFTAag--tTAGFILWMr-gRGILVDPPAhsa-hyLRRNGISSRKITHVILTHCHADHDAGTFQKILle-qrV 139  Emiliania huxley...
ELR14162   433 TFIGTsHGFDAkg--rTTGFIIWLn-gYGVLVDPPMqttdsfAATYGIHHRFVTKVILTHCHSDHDSGVIQMILeg-ekI 508  Acanthamoeba cas...
CCQ91984   291 TFLGVgSGFTHkr--hNSCMIAWSe-gKGIMVDAFSdnd-raIVQNGISGEDVPYMFLTHIHSDHDAGFIEKILsg-qrL 365  Nitrospina graci...
ACL25462   212 QFIGGsDGFDPtg--iTTCFLAYLgtgQPLLFDAAAyln-vrLAYLGLSPRQIDLVVISHLHEDHIAGLPELILtggkrV 288  Chloroflexus agg...

Feature 1                                                                ##                    
Q8MLZ3     419 TVVTTPTILGSFLRKYGALsnlstdllrrlFIFRPVMIGEPMIIs---GAEFRFFYTIHTIPTISFEVFyg-----gkSI 490  Dictyostelium di...
Q8MM62     593 TLYTTKTINESYMRKLKALtglpeqslknyYTWVPVTIGNKIKIl---GAEFEFDYSFHVIPTIRFKLEiy-----nkKI 664  Dictyostelium di...
NP_712110  283 TIHATETVMDSFLRKYSALtkipkkelqelFHFQPIIIGKATMIn---GGEFNFHYALHSIPSVGFEFFfq-----dqSF 354  Leptospira inter...
EEY69474   256 ALITTDTIYRSFLRKYSALsgfepsflervLDHRLVRINDLTQIr---GAEFRFFYSLHSIPCVGFEVTyg-----dkKI 327  Phytophthora inf...
CAK89179   361 ILISTATIKESFVRKYAAMtgfsadyieslFNFERVIVGHPLKIn---GASFDFHYSLHSIPCLSFTVRlg-----gkSI 432  Paramecium tetra...
EGG20846   567 TIFTTKTINESYKRKAKALtgies--isdyYNWAPVPIGEKIRIq---GAEFEFDYSYHTIPTIRFKVSfc-----gkSI 636  Dictyostelium fa...
EMS77565   289 TLYTTPTVFNSFIRKSAALihidrsrlqkaFSFVPIHTGEPINIh---GAMFEFNYSFHSIPTIFFQVSha-----gkTF 360  Desulfotignum ph...
EOD20995   140 TVLTTRTIMAAFVRKYALIsemnydflqrlFCFHSVKIGEPVHFq---GGSIKFFYSLHALPCIGFRAEla-----gkSI 211  Emiliania huxley...
ELR14162   509 ELYTTRTVNESYKRKVNAItglad--vgeyYTFRPVLIGDKVNIh---GAEFEFDYSFHTVPTVRFKLSfl-----gkSI 578  Acanthamoeba cas...
CCQ91984   366 KVLSSRIIFESFLRKIQAVtlfpaevlenlVDFIELEPYKKTKLsgfkRTFIEFDYAFHSIPTGRFKLIykdengktrTI 445  Nitrospina graci...
ACL25462   289 RLVTAQPIYRSLLRVLGAMldlapaavaelFDFFPLDPGHALEVn---GYRFEATYAVHSIPTIAVRVG---------GI 356  Chloroflexus agg...

Feature 1          #                                      #
Q8MLZ3     491 FYSGDtcydpnrikdmnkrGIMKTSRMKFFLRp---WNHTVVLH 531  Dictyostelium discoideum
Q8MM62     665 SYSADtfydlqkfkqlkdqGVLSKKRIERLKSf--vFDADMIIH 706  Dictyostelium discoideum
NP_712110  355 IYTSDhlnepeihdkmyaqGILPESRWKFFKEf--pWERRIIYH 396  Leptospira interrogans serovar Lai str. 56601
EEY69474   328 AFSGDhlndvdkihqleseGVLSPARAHELLNf--pWHCDAILH 369  Phytophthora infestans T30-4
CAK89179   433 YFSGDtfyepnglkaiyekGVISESRFNYLISed-kWNNSLILH 475  Paramecium tetraurelia
EGG20846   637 AYSSDtkycpeslsdlvrkGVINERRESSLRMf--vFDADVMIH 678  Dictyostelium fasciculatum
EMS77565   361 IYSSDtrndpdhicimhekGIMSKSRRDFLLRf--pWDRDVIFH 402  Desulfotignum phosphitoxidans DSM 13687
EOD20995   212 VYSSDtyydpdglaalqqrGIISAERCASLCTdcsvQQADLLLH 255  Emiliania huxleyi CCMP1516
ELR14162   579 SYSSDtyynpqalaslvsqGIINYQREISLRMf--lFDADMIIH 620  Acanthamoeba castellanii str. Neff
CCQ91984   446 AHSGDtkydrdlvnswyehGHLSPDRREQILGf--lWDADLIMH 487  Nitrospina gracilis 3/211
ACL25462   357 GYSGDmrydeawlehlyrqGQLSATRLAELRRf--aEGAEVLVH 398  Chloroflexus aggregans DSM 9485

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