4OJX,4OJV


Conserved Protein Domain Family
class_II_PDE_MBL-fold
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cd07735: class_II_PDE_MBL-fold 
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class II cyclic nucleotide phosphodiesterases Saccharomyces cerevisiae PDE1, Dictyostelium discoideum PDE1 and PDE7, and related proteins; MBL-fold metallo-hydrolase domain
Cyclic nucleotide phosphodiesterases (PDEs) decompose the second messengers cyclic adenosine and guanosine 3',5'-monophosphate (cAMP and cGMP, respectively). Saccharomyces cerevisiae PDE1 and Dictyostelium discoideum PDE1 and PDE7, have dual cAMP/cGMP specificity. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293821
Aligned: 153 rows
Threshold Bit Score: 157.758
Created: 9-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:4OJX: Saccharomyces cerevisiae Pde1 protein binds two zinc ions and a guanosine 5'-monophosphate
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                                                                      
4OJX_A      4 FEITILGANGGp-----------tEYGTQCFILKPartedpeLIAVDGGAGMYQLREMlvqgrnenegddelvpsfyehd 72  Saccharomyces cere...
ABM93028    6 VRLQVLGCSGSia----------sGSRTTAFLLDD-------NVLIDAGTGVGDLALDam-------------------- 48  Methylibium petrol...
CBA30928    1 MKIRVLGCSGAia----------kHCRTTSFLLGA-------KVLIDAGTGVGDLTLDem-------------------- 43  Curvibacter putati...
ADE11116    1 MRITTLGCNGSit----------gDLRTTCYMVDE-------DILIDAGSGAGDLRLEqa-------------------- 43  Sideroxydans litho...
ADV01962    1 MKVRILGCSGTla----------kGCRTTSFLLGE-------RILVDAGTGVGELTLEem-------------------- 43  Alicycliphilus den...
EFV95853    4 MRFHILGCSGGlggtpgtagrpgrPARTSSFLVDH-------DILVDAGTGVEDLSVEdm-------------------- 56  Lautropia mirabili...
BAL97981    1 MQIRVLGCSGSia----------aGNRTTSFLVDD-------DVLVDAGTGVGDLELDel-------------------- 43  Rubrivivax gelatin...
CCU61369    1 MRVTILGCTGGva----------aDLRSTCLMLDD-------DILVDAGTGAGDLTVCqm-------------------- 43  Nitrosospira sp. APG3
EYC49918    1 MKVRVLGCSGAia----------rGSRTTSFLIDT-------DILIDAGTGVGDLTVGem-------------------- 43  Hylemonella gracil...
KJS73737    1 MQVRVLGCSGAia----------rDARTTSFLLDE-------RILIDAGTGVGDLTLEem-------------------- 43  Comamonadaceae bac...

Feature 1                                                            # # ##                   
4OJX_A     73 repieffidsklniqkglsksllqslkrqgehfesantmkktyevfqgITDYYITHPHLDHISGLVVNSPSiyeq----e 148 Saccharomyces cere...
ABM93028   49 ----------------------------------------------arVDDILVSHSHLDHVLAIPLLADSvmklrlaqp 82  Methylibium petrol...
CBA30928   44 ----------------------------------------------qkIDHVFLTHSHLDHIAALPLMLDAvga-----r 72  Curvibacter putati...
ADE11116   44 ----------------------------------------------iaIDAVFLTHSHLDHCAFLPMLADAags-----f 72  Sideroxydans litho...
ADV01962   44 ----------------------------------------------qrVDHVFLTHSHLDHIAALPLLLDAvga-----h 72  Alicycliphilus den...
EFV95853   57 ----------------------------------------------rrIDHVFLTHSHLDHICALPLMLDTvgs-----s 85  Lautropia mirabili...
BAL97981   44 ----------------------------------------------arIDDVFVSHSHLDHVLAIGLLADSvkrrr-aaa 76  Rubrivivax gelatin...
CCU61369   44 ----------------------------------------------lrVDTVFLTHSHLDHVALLPMLADVagp-----r 72  Nitrosospira sp. APG3
EYC49918   44 ----------------------------------------------lrIDHVFITHAHLDHIAALPLMLDAmga-----r 72  Hylemonella gracil...
KJS73737   44 ----------------------------------------------lrIEHVFLTHSHLDHIAALPLMIDSmaa-----s 72  Comamonadaceae bac...

Feature 1                                                                                     
4OJX_A    149 nsKKKTIWGLPhTIDVLQKHVFNDLIWPDLtaersRKLKLKCLNP--KEVQKCTIf----PWDVIPFKVHHGIGvktgap 222 Saccharomyces cere...
ABM93028   83 erGPIRVHGLPeTLAALRAHLFNGQLWPDFtsipsAAYPIIRLLPf-AIGDTLRFgrgdaERHVEVLPASHTVP------ 155 Methylibium petrol...
CBA30928   73 rdKPISLYGLQsTLDALKTHIFNDVIWPDFlkipsAESPFLRLFPieVGQQTLVD-----GLLVEALPAQHSVP------ 141 Curvibacter putati...
ADE11116   73 rkTPLSVYALPeTIATLRQHMFNNQLWPDYtmlpaPELPYIRFHPirLGETAELD-----GRRITALPASHSVP------ 141 Sideroxydans litho...
ADV01962   73 raRPLQVHALPaTLDALRAHVFNGVIWPDFtriptPQAPFVRLLPl-GVGDVFVVa----GTPLEVLPARHSVP------ 141 Alicycliphilus den...
EFV95853   86 reRPIIVHALPeTIQALKDHIFNWVIWPDFteiphFERPWMVYSPlqVGHPVQIG-----NRTIRPITANHTVP------ 154 Lautropia mirabili...
BAL97981   77 grPPIRVHALPeTLAALHAHVFNGVIWPDFtqlpsPQQPMLAFVPfaVGERLDLGr----GRWLEVLPATHTVP------ 146 Rubrivivax gelatin...
CCU61369   73 rdTPLTVYALPeTIAILKQDMFNFRLWPDYtvlpsPEKPYVVFRSitVGQTVELS-----GRKITPLPVRHAVP------ 141 Nitrosospira sp. APG3
EYC49918   73 rrQPVMVHALPqTIEAMRAHIFNNLIWPDFsripsEEAPFMRFVPi-ETGDVVEIg----GRRIEALPAQHTVP------ 141 Hylemonella gracil...
KJS73737   73 lrRPLVVHALPeTIAALRQHIFNHVIWPDFsvipsPEKPFLRFEAl-QVGEVHEVc----GQRVRVLPAQHNVP------ 141 Comamonadaceae bac...

Feature 1                                #                                                   #
4OJX_A    223 vySTFYIFRDRk------sKDCIIVCGDVEQdrreseeslLEEFWSYVAeni-plvHLKGILVECSCPLSskp-eqLYGH 294 Saccharomyces cere...
ABM93028  156 --ACGFAVDSE--------EGWWVYSGDTGS---------NPALWAALKg-----rRIAHLIIETAFGDDerwladLSGH 211 Methylibium petrol...
CBA30928  142 --ALGYAVSKN--------GPCWVFTGDTGN---------CTDLWSRVNq-----lKVGMLVIETAFSNKemelavLSGH 197 Curvibacter putati...
ADE11116  142 --CIAYRVDNG--------TASWVYSADTTF---------CADFWQELNri----dNLRYLLIENTFRNDnaagaqRSGH 198 Sideroxydans litho...
ADV01962  142 --AVGYAARGQ--------RGWWVYSGDTEGq--------EPAFWRRVNalrqspgGVAALCIETAFSNAeaelarKSQH 203 Alicycliphilus den...
EFV95853  155 --AVGFHIGAT--------AGSLVYSGDTLP---------TEEFWRTVNgi----sDLRHLILETAFANRerdlavTAKH 211 Lautropia mirabili...
BAL97981  147 --AVGFALIDAa-------GRAWAYSGDTGP---------APALWRRLEq-----lDLRGLIVETAFDDEeramaeLSQH 203 Rubrivivax gelatin...
CCU61369  142 --GVAYQLDSG--------NASFVFSGDTTY---------HEPFWNALNai----sNLRYLMIEATFLNCntagaeASGH 198 Nitrosospira sp. APG3
EYC49918  142 --AVGYAASADptarkdgkAATWVFSGDTGP---------NPSFWQRVNql----dEVRMLVIETAFSRResklaeISQH 206 Hylemonella gracil...
KJS73737  142 --AVGYAVATP--------SGHWAFTGDTCS---------NPAFWRCINe-----lPLAMLVIETAFSERehrlalRSKH 197 Comamonadaceae bac...

Feature 1                                    #
4OJX_A    295 LSPIYLINELSNLntlynsskgLSGLNVIVTH 326 Saccharomyces cerevisiae S288c
ABM93028  212 LAPSSLATELAQL---------DGSVPVHITH 234 Methylibium petroleiphilum PM1
CBA30928  198 LAPDSMVVQLDYLr-------sDRNFPIFITH 222 Curvibacter putative symbiont of Hydra magnipapillata
ADE11116  199 NTAELLAQGRRLL---------QRPVELFIVH 221 Sideroxydans lithotrophicus ES-1
ADV01962  204 LSPATLARELTALp-------pGADLPIYITH 228 Alicycliphilus denitrificans BC
EFV95853  212 LYPIQLSEELARL---------CVDPQIHITH 234 Lautropia mirabilis ATCC 51599
BAL97981  204 LCPALLRDELARL---------PRGVDVYITH 226 Rubrivivax gelatinosus IL144
CCU61369  199 MRPELLAKGLNQL---------NKAVRLLITH 221 Nitrosospira sp. APG3
EYC49918  207 LAPDTLAQELAQIa-------pGRDYPIYITH 231 Hylemonella gracilis str. Niagara R
KJS73737  198 LCPSLLAQELAQLdt-----rrHPGLRIGITH 224 Comamonadaceae bacterium BIC-A1/1_c1

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