2BIB


Conserved Protein Domain Family
ComA-like_MBL-fold
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cd07731: ComA-like_MBL-fold 
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Competence protein ComA, ComEC and related proteins; MBL-fold metallo hydrolase domain
This subgroup includes proteins required for natural transformation competence including Neisseria gonorrhoeae ComA, Pseudomonas stutzeri ComA, Bacillus subtilis ComEC (also known as ComE operon protein 3) and Haemophilus influenza ORF2 encoded by the rec-2 gene, as well as Escherichia coli YcaI which does not mediate spontaneous plasmid transformation on nutrient-containing agar plates. It also includes the phosphorylcholine esterase (Pce) domain of choline-binding protein e from streptococcus pneumonia. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293817
Aligned: 424 rows
Threshold Bit Score: 116.079
Created: 9-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2BIB : Streptococcus pneumonia phosphorylcholine esterase (Pce) domain of choline-binding protein E binds two metal ions and phosphocholine
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                   # 
2BIB_A      7 KIHFINVqeGGSDAIILESnGHFAMVDTGEdydfpdgsdsrypwregietsykhvltdRVFRRLKELSVQKLDFILVTHT 86  Streptococcus pneu...
EGN75612  573 AVHALDV--GQGTAIIVQRgRKAMIFDAGPgfrfg------------------snigeTTLIPFLNYHQLTPEWLIISHD 632 Idiomarina sp. A28L
AGH80774  524 YVEVIDV--GQGLSVLIRTrDQHLLYDTGAryrsgf-----------------smaksEVLPYLRHVGVTSLAYLVISHS 584 Psychromonas sp. C...
ACQ93834  482 RVDMLDV--GQGLSVLISQdERALLFDTGDayqggy-----------------nmadaAIFPMLEYRGIKQLDYLIVSHR 542 Tolumonas auensis ...
ENY71751  473 RVSVLDV--GQGLSVVISRgGRALVYDTGDsypggy-----------------smadaALLPHLHERGITRVDTLVISHK 533 Aeromonas diversa ...
EOQ71867  550 QINILDV--GQGQAIFLQHpQQTWLIDTGGsydeka----------------fsigqnVVIPYLRQKGIKQLDHVILSHL 611 Acinetobacter pitt...
ABM02741  541 QVEILDI--GQGLSVLVKSqGQSLLYDTGPrypsgf-----------------ttaavETLPYLHSIGIERLDYFVISHS 601 Psychromonas ingra...
EQC04270  448 QLRVLDV--GQGLAVLISRgERAILYDTGDsypggy-----------------nmaqaVILPVLGHLGIKQLDRLIISHK 508 Aeromonas salmonic...
KFZ35981  533 QLHIVDV--GQGLAVIAQQgKYGLLYDTGAsfddf------------------syaerAILPLLRQRGISELEYLILSHG 592 Shewanella sp. YQH10
ACJ29022  528 KVHMLDV--GQGMSVVIESnGRAIVYDTGAsfgasf-----------------syaerVVLPFLREKGISQVDYLVISHA 588 Shewanella piezoto...

Feature 1     ####                                                                            
2BIB_A     87 HSDHIGNVDELLSTYPVDRVYLKkysdsritnserlwdnlygydkvlqtatetGVSVIQNItqGDAHFQfGDMDIQLYNY 166 Streptococcus pneu...
EGN75612  633 HQDHTGGVQSLLTQWPQLSMQRSrfhtvegenwg---------wlpqqfpeqhQAGDSWPCawGQQWLW-QGVRIKALAP 702 Idiomarina sp. A28L
AGH80774  585 DNDHAGGAEIINTALRPKVIKLGepl------------------------rklHFMQAQYCqaGQQWRL-GHLTVSVLSP 639 Psychromonas sp. C...
ACQ93834  543 DKDHSANWQRIAGKYPQARIVSSs----------------------------aLTVDTLICqrGQQWQW-GKLQVMVLSP 593 Tolumonas auensis ...
ENY71751  534 DRDHSGGRRRLLRQMAVGREISSy----------------------------pFAGSTEPCqaGQQWRW-QEVQVRVLWP 584 Aeromonas diversa ...
EOQ71867  612 DQDHSGAFPSIAQAFPIKQVISNelw------------------------teqIKEPFTYChqGQKWQY-PQLDIEILWP 666 Acinetobacter pitt...
ABM02741  602 DIDHAGGADIINRAFLPEYILVGepla----------------------ppalQNEKTILCraGMKWSL-GSLSVKVLSP 658 Psychromonas ingra...
EQC04270  509 DRDHAGNRQLLLKALPVRGELSSf----------------------------aFEPAVLLCerGQQWRW-QGLTFAVLWP 559 Aeromonas salmonic...
KFZ35981  593 DNDHAGGAQVISAHYPQAKVITDl-----------------------------TILPATDNcrPHTVQW-RKLTLNFLGP 642 Shewanella sp. YQH10
ACJ29022  589 DNDHAGGVGVVMAAFPNTQVISDd-----------------------------SAKGAIDCr-PKAFMW-QAIKLEIVAP 637 Shewanella piezoto...

Feature 1                     #                       #                           ##
2BIB_A    167 EnetdssgelkkiwDDNSNSLISVVKVN----GKKIYLGGDLdn---vhGAEDKYGPLigkVDLMKFNHH 229 Streptococcus pneumoniae
EGN75612  703 Lpgp--------sfGPNNDSCVLQLTYN----GQSILLTGDIqrq-telRMVGRYGNSl-qSDVLILPHH 758 Idiomarina sp. A28L
AGH80774  640 Fer---------lkNSNNNSCVLRISDG----KRAVLLSGDInkk-qeaLIVQRFASQl-sSQILIAPHH 694 Psychromonas sp. CNPT3
ACQ93834  594 Rsss--------ggDVNEDSCVLRISDN----QHSLLLTGDAerk-aeaELIRLPRQLl-qSQILSSPHH 649 Tolumonas auensis DSM 9187
ENY71751  585 Esghr------adnSRNNGSCVLRLDGE----GWSLLLPGDIeke-aeaALVARWGSAl-rSDLLVVPHH 642 Aeromonas diversa 2478-85
EOQ71867  667 Kekdln----lvssNQNQYSCVVYIHLKqvkgYQNYLIMGDAgwe-aeyQLIKEYPDLk--VDVLVLGHH 729 Acinetobacter pittii ANC 4052
ABM02741  659 Lkt---------gtNNNNNSCVLRIDDG----NYSLLLTGDIekkqeikLIVQYRGDLk--STILLAPHH 713 Psychromonas ingrahamii 37
EQC04270  560 Ert---------ghGRNNDSCVVRISDG----QHSVLLSGDIeqraeqrLVLLEGEGLa--STLLVSPHH 614 Aeromonas salmonicida subsp....
KFZ35981  643 Lap----------aRGNNGSCVMQLTDE----KFSVLLPGDIelp-aeiGLVKSDAQLn--SDLLLVPHH 695 Shewanella sp. YQH10
ACJ29022  638 Tfv----------tAGNNGSCVIRLSKA----GNSILLTGDIeaa-aelALLSDKAIV---SQVMSAPHH 689 Shewanella piezotolerans WP3

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