2CFU,2CG2,2CFZ,2YHE,4NUR,2CG3,4PDX,4AV7


Conserved Protein Domain Family
arylsulfatase_Sdsa1-like_MBL-fold
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cd07710: arylsulfatase_Sdsa1-like_MBL-fold 
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Pseudomonas aeruginosa arylsulfatase SdsA1, Pseudomonas sp. DSM6611 arylsulfatase Pisa1, and related proteins; MBL-fold metallo-hydrolase domain
Arylsulfatase (also known as aryl-sulfate sulfohydrolase, EC 3.1.6.1). Pseudomonas aeruginosa SdsA1 is a secreted SDS hydrolase that allows the bacterium to use primary sulfates such as the detergent SDS common in commercial personal hygiene products as a sole carbon or sulfur source. Pseudomonas inverting secondary alkylsulfatase 1 (Pisa1) is specific for secondary alkyl sulfates. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293796
Aligned: 180 rows
Threshold Bit Score: 194.642
Created: 19-May-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2CFU: Pseudomonas aeruginosa Sdsa1 binds two zinc ions and the substrate analog 1-decane sulfonic acid
  • Structure:2CFZ: Pseudomonas aeruginosa Sdsa1 binds two zinc ions and 1-dodecanol
  • Comment:1-dodecanol is produced during SdsA1-mediated cleavage of SDS
  • Structure:2CG2: Pseudomonas aeruginosa Sdsa1 binds two zinc ions and a sulfate ion
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                          # ####     
2CFU_A    106 GLFEVAE-GIYQVRGf--DLANITFIRGdsGWIVVDTLTTPATARAAYELVSRel---geRPIRTVIYSHAHADHFGGVR 179 Pseudomonas aerugi...
EED32294   34 ELFQIGDsPVWDYNTpnrGFGNVIMIEGddGLIIVDTTTANEHAAVAESAFREis----dKPVKAVIYTHHHADHINGAG 109 gamma proteobacter...
CDT30037  145 VIFKLSD-RMYNAFGf--EGASITFLQGdkGLIIIDAGSTAETGEAMLSAYREatg--deREVHTIFYTHHHPDQWAGTE 219 Vibrio sp. J2-15
AJZ58447   56 RIYRVAE-RVYCAVGy--AIANIIFVVGdeGIVVIDTTEAVSAAKRIYEDFCAidprhakLPVKAVVYTYNHTDHTGGVR 132 Burkholderia fungorum
EQF23242   27 KIYKTGE-NVYSAVGf--GLSYPVMIEGtdGIIIIDPGETIEMMEEIMKHFRKit----dKPIKAVIISHNHGDHWGGMS 99  Peptoclostridium d...
BAN50033   80 KVYKIAD-NVYSAVGw--NLANSVMIEApeGLIIVDTGESAEQSRKVLTEFRKis----dKPIKAIVYTHFHPDHINGVK 152 Pseudomonas resino...
GAM76367  119 AVIQVDD-NVYLAYGf--GLDTPVMIEGddGIIIVDPGESVQMAEAAKAQFRQit----dKPVKAIIYSHNHIDHISGVR 191 Vibrio sp. JCM 19241
AAZ26986   95 GIFSYKE-KFYQVYGy--GLTSPMIVDGdnGLLILDPVESVDKMKNVMDDFRKvtg--nkKPVAAIMYSHWHPDHYAGVR 169 Colwellia psychrer...
EEX94733  153 TIYKLSD-RVYQIYGf--EMTNSTIVVGdtGLIAFDTHYSNEIAEVAIEKFREatg--idLPFHTIIYSHHHPDQLSGTG 227 Vibrio orientalis ...
CDT27165   83 KIQEIAPgKLYSISGf--QLASTLVAVGndGLIIVDPGENDTAAKESMEAFNQfs----tLPVKAVIYTHRHPDHAFGAA 156 Vibrio crassostreae

Feature 1                                           #  #  ## #                   #            
2CFU_A    180 GLVEpqqv-asgaVQIIAPAGFMEAAIKENVLa-GNAMMRRATYQYGTQLPkgpq--gqvDMAIGKGLARGpl------s 249 Pseudomonas aerugi...
EED32294  110 AFIGrada-esgrVKVIAAQNFLRELEDENQVt-APIMGVRALYMYGQLLDpvtdgrdyhVSCCGYTLGGElg------t 181 gamma proteobacter...
CDT30037  220 GLATredf-esgkINVIAHVDFQKKMNEESGIy-LNQQSIRTAYAFGAFIPhnnd--ydkGVNQGVGYPADivmqsqnks 295 Vibrio sp. J2-15
AJZ58447  133 AFVDeaal-eagsIEIIAHRSLMETVINNANLv-APILATRSAYSFGTLLPegat--gkvNAGIGPVLIAEpa------s 202 Burkholderia fungorum
EQF23242  100 VCVSqeqs-qnkeILVIVDETFIKHFSQASGEl-LDIRMGRAVWMYGSILPkgeh--gyvNLGCGPILSKGsn------k 169 Peptoclostridium d...
BAN50033  153 GFVSeeqv-ksgeVQIYAQETLLDNVVTQGALv-GPILGMRSGYSFGVALPdadk--kdmNAGLGPLAHEGks------t 222 Pseudomonas resino...
GAM76367  192 AWTNdeev-asgkVKIIAQDGLTAAVANWSSNl-GTLFGHRTSYTGAKHVEegeh--gtvNDGLGPRFMQGdi------s 261 Vibrio sp. JCM 19241
AAZ26986  170 GIEGae------kALIIAHDTFMTNVVKGSMGgtGPALGFRVDYSLGTLLSvnen--griNGGLGPDFEINeh------s 235 Colwellia psychrer...
EEX94733  228 AYVTpeqv-tkgeINVIAHDKLFEMFALESGFl-SPLMAHRGVYAFGAALDvgpe--gyvGQGIGYVPKEVynpr--ttf 301 Vibrio orientalis ...
CDT27165  157 GWGVtedqvasgeVKIIASDNFIPNLVNDVGVt-GSILTQRTAYASVYLPKgekg--gpaHYGLGPTFTAGpv------s 227 Vibrio crassostreae

Feature 1                                     #                  #       ##  # #    #         
2CFU_A    250 LLAPTRLIEGe--GEDLVLDGVPFTFQNTPgTESPAEMNIWLPrqKALLMAENVV-GTLHNLYTLRGAEVRDALGWSKYI 326 Pseudomonas aerugi...
EED32294  182 YIPPNHFVDQ---REELTIAGIRMELFQTG-GESASHLAIWLPdyQVMLTGDEVQgPNYPNLHSLRGTKPRDAIAWVTAI 257 gamma proteobacter...
CDT30037  296 FFAPNILVDD---LMIMKVDGLTLEFFHTP-GEAPDGVALYVHetGDMVGGDTIQgETIPNLYTIRGAEYRDGLEWADSI 371 Vibrio sp. J2-15
AJZ58447  203 FFAPTRVFDD---RLDIVLAGVRFEFRYAP-SEADDEIVMWLPglDVLLSAEVIQgECLANVHTLRGTRYRDPVRWYQTI 278 Burkholderia fungorum
EQF23242  170 FIEPNTFVSVe-dGLKITISGVDLELFHCE-AETEDAMCIFLPkeKIMFVGDAVQgEIFPNIYTVRGTVRDAKKWYTGID 247 Peptoclostridium d...
BAN50033  223 FIAPTITFKD---KLDTTIAGLPIQFLHVP-SEAPDEIVLYLPdnRVLISAEVTQgPTLPNIHTLRGTKFRDPVVWVASL 298 Pseudomonas resino...
GAM76367  262 FIEPNLTFKD---RLDITISGVKMEIVNVP-SETKDEIVVYLPeqKILHAAEVLQgENFPNLHTIRGTKFRDPSMWFKGI 337 Vibrio sp. JCM 19241
AAZ26986  236 LIAPNTLVKGkngQLAMTIAGVKVEFKHVP-SEASDEITAYFPdfNMLFGSEVIQgESFPNLHTIRGTQYRDPSVWFPGV 314 Colwellia psychrer...
EEX94733  302 TAKPNITIDD---QQVMVIDGVEMEFFHVP-GESSDHIAIYMPenGEMLLGDSIQgETIPNVYTIRGAKYRDMEEWKESV 377 Vibrio orientalis ...
CDT27165  228 FFMPNVLVSNd-dPLKINVSGIEMEIFGAYgDAGDDEVDIYFPqfKHVHGSETIQgETFPNLYTLRGTKYRDVQKWYEGI 306 Vibrio crassostreae

Feature 1                      #      
2CFU_A    327 NQALHrfgrQAEVMFAVHNWPRWG 350 Pseudomonas aeruginosa PAO1
EED32294  258 DRMRAy---DAEHLVPSHGQPLSG 278 gamma proteobacterium NOR5-3
CDT30037  372 DRMRRy---QPKTLSLHHGRSAVS 392 Vibrio sp. J2-15
AJZ58447  279 DMMRGf---NAAHMVPAHGRPVSG 299 Burkholderia fungorum
EQF23242  248 KIRKY----KPHYLVGTHMRPLHG 267 Peptoclostridium difficile CD160
BAN50033  299 DKLRAf---QADYMVPLHGQPVSG 319 Pseudomonas resinovorans NBRC 106553
GAM76367  338 DIMRQf---DTEVMINSHGRPVEG 358 Vibrio sp. JCM 19241
AAZ26986  315 DTLLEy---NAQAMMVSHGRPVVG 335 Colwellia psychrerythraea 34H
EEX94733  378 DRMRSy---HAKGFTNHHGRPVIG 398 Vibrio orientalis CIP 102891 = ATCC 33934
CDT27165  307 DTLSEya-eKSETYSGSHMRAWVG 329 Vibrio crassostreae

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