1JT1,1L9Y,2FU9,3VQZ,3LVZ


Conserved Protein Domain Family
MBL-B3-like
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cd07708: MBL-B3-like 
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metallo-beta-lactamases, subclass B3; MBL-fold metallo-hydrolase domain
MBLs (class B of the Ambler beta-lactamase classification) are a diverse group of metallo-enzymes that are capable of catalyzing the hydrolysis of a wide range of beta-lactam antibiotics. MBLs have been divided into three subclasses B1, B2 and B3, based on sequence/structural relationships and substrates, with the B1 and B2 MBLs being most closely related to each other. Subclass B3 enzymes are most active with two zinc ions bound in the active site, and have a broad-spectrum substrate profile. B3 MBLs include Fluoribacter gormanii FEZ-1, Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) GOB-1, Stenotrophomonas Maltophilia L1, and Bradyrhizobium diazoefficiens BJP-1, Serratia marcescens SMB-1, and Pseudomonas Aeruginosa AIM-1. These B3 enzymes have a modified Zn2/DCH site (Asp-His-His).
Links
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Statistics
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PSSM-Id: 293794
Aligned: 5 rows
Threshold Bit Score: 383.049
Created: 24-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3VQZ: Serratia marcescens SMB-1 metallo-beta-lactamase binds the inhibitor mercaptoacetate and two zinc ions
  • Structure:2FU9: Stenotrophomonas maltophilia L1 metallo-beta-lactamase binds the inhibitor MP2 and two zinc ions
  • Comment:MP2 is also known as N-[(benzyloxy)carbonyl]-L-cysteinylglycine
  • Structure:1JT1: Legionella gormanii FEZ-1 metallo-beta-lactamase binds the inhibitor d-captopril, SO4, and two zinc ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                        # # ##       
1JT1_A      4 MPNPFPPFRIAGNLYYVGTDDLASYLIVTPRGNILINSDLeANVPMIKASIKKLGFKFSDTKILLISHAHFDHAAGSELI 83  Fluoribacter gormanii
1L9Y_A      4 MPNPFPPFRIAGNLYYVGTDDLASYLIVTPRGNILINSDLeANVPMIKASIKKLGFKFSDTKILLISHAHFDHAAGSELI 83  Fluoribacter gormanii
2FU9_A     17 WLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMpQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAEL 96  Stenotrophomonas m...
3VQZ_A      5 WSSPQQPFTIYGNTHYVGTGGISAVLLSSPQGHILVDGTTeKGAQVVAANIRAMGFKLSDVKYILSTHSHEDHAGGISAM 84  Serratia marcescens
3LVZ_A     34 WTAPFEPFQLIDNIYYVGTDGIAVYVIKTSQGLILMDTAMpQSTGMIKDNIAKLGFKVADIKLILNTHAHLDHTGGFAEI 113 Bradyrhizobium dia...

Feature 1                                 #                                     #             
1JT1_A     84 KQqTKAKYMVMDEDVSVILSGGk-sDFHYANdssTYFTQSTVDKVLHDGERVELGGTVLTAHLTPGHTRGCTTWTMKLKD 162 Fluoribacter gormanii
1L9Y_A     84 KQqTKAKYMVMDEDVSVILSGGk-sDFHYANdssTYFTQSTVDKVLHDGERVELGGTVLTAHLTPGHTRGCTTWTMKLKD 162 Fluoribacter gormanii
2FU9_A     97 KRrTGAKVAANAESAVLLARGGs-dDLHFGDg--ITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTR 173 Stenotrophomonas m...
3VQZ_A     85 QKlTGATVLAGAANVDTLRTGVspkSDPQFGs-lSNFPGSAKVRAVADGELVKLGPLAVKAHATPGHTEGGITWTWQSCE 163 Serratia marcescens
3LVZ_A    114 KKeTGAQLVAGERDKPLLEGGY---YPGDEKnedLAFPAVKVDRAVKEGDRVTLGDTTLTAHATPGHSPGCTSWEMTVKD 190 Bradyrhizobium dia...

Feature 1                # #                                        #                         
1JT1_A    163 HGKQYQAVIIGSIGVNpg--yKLVDnitypKIAEDYKHSIKVLESMRCDIFLGSHAGMFDLKNKYVLlskgqnnpFVDPT 240 Fluoribacter gormanii
1L9Y_A    163 HGKQYQAVIIGSIGVNpg--aKLVDnitypKIAEDYKHSIKVLESMRCDIFLGSHAGMFDLKNKYVLlskgqnnpFVDPT 240 Fluoribacter gormanii
2FU9_A    174 NGKPVRIAYADSLSAPg---yQLQGnprypHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGAr------aGAKAL 244 Stenotrophomonas m...
3VQZ_A    164 QGKCKDVVFADSLTAVsadsyRFSDh---pEVVASLRGSFEAVEKLSCDIAIAAHPEVNDMWTRQQRaakegnsaYVDNG 240 Serratia marcescens
3LVZ_A    191 GKEDREVLFFCSGTVAl---nRLVGqptyaGIVDDYRATFAKAKAMKIDVLLGPHPEVYGMQAKRAEmkdgapnpFIKPG 267 Bradyrhizobium dia...

Feature 1                
1JT1_A    241 GCKNYIEQKAN 251 Fluoribacter gormanii
1L9Y_A    241 GCKNYIEQKAN 251 Fluoribacter gormanii
2FU9_A    245 TCKAYADAAEQ 255 Stenotrophomonas maltophilia
3VQZ_A    241 ACRAIAAAGRK 251 Serratia marcescens
3LVZ_A    268 ELVTYATSLSE 278 Bradyrhizobium diazoefficiens USDA 110

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